B1WC40
PR
Gene name |
Ncbp2 (Cbp20) |
Protein name |
Nuclear cap-binding protein subunit 2 |
Names |
20 kDa nuclear cap-binding protein, NCBP 20 kDa subunit, CBP20 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:689116 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for B1WC40
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-B1WC40-F1 | Predicted | AlphaFoldDB |
No variants for B1WC40
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for B1WC40 | |||||
No associated diseases with B1WC40
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| mRNA cap binding complex | Any protein complex that binds to an mRNA cap at any time in the lifetime of the mRNA. |
| nuclear cap binding complex | A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| RNA cap binding complex | Any protein complex that binds to a specialized RNA cap structure at any time in the lifetime of the RNA. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| RNA 7-methylguanosine cap binding | Binding to a 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II. |
| RNA cap binding | Binding to a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule. |
| snRNA binding | Binding to a small nuclear RNA (snRNA). |
13 GO annotations of biological process
| Name | Definition |
|---|---|
| gene silencing by RNA | A process in which an RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation. |
| histone mRNA metabolic process | The chemical reactions and pathways involving an mRNA encoding a histone. |
| mRNA cis splicing, via spliceosome | The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript. |
| mRNA export from nucleus | The directed movement of mRNA from the nucleus to the cytoplasm. |
| mRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
| mRNA transcription by RNA polymerase II | The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. |
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. |
| positive regulation of mRNA 3'-end processing | Any process that activates or increases the frequency, rate or extent of mRNA 3'-end processing. |
| positive regulation of RNA export from nucleus | Any process that activates or increases the frequency, rate or extent of directed movement of RNA from the nucleus into the cytoplasm. |
| pre-mRNA cleavage required for polyadenylation | The targeted, endonucleolytic cleavage of a pre-mRNA, required for polyadenylation of the 3' end. This cleavage is directed by binding sites near the 3' end of the mRNA and leaves a 3' hydoxyl end which then becomes a target for adenylation. |
| regulation of translational initiation | Any process that modulates the frequency, rate or extent of translational initiation. |
| RNA splicing | The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. |
| snRNA export from nucleus | The directed movement of snRNA from the nucleus to the cytoplasm. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q08920 | CBC2 | Nuclear cap-binding protein subunit 2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q5ZKR5 | NCBP2 | Nuclear cap-binding protein subunit 2 | Gallus gallus (Chicken) | PR |
| P52298 | NCBP2 | Nuclear cap-binding protein subunit 2 | Homo sapiens (Human) | PR |
| Q9CQ49 | Ncbp2 | Nuclear cap-binding protein subunit 2 | Mus musculus (Mouse) | PR |
| B1WC40 | Ncbp2 | Nuclear cap-binding protein subunit 2 | Rattus norvegicus (Rat) | PR |
| Q93594 | ncbp-2 | Nuclear cap-binding protein subunit 2 | Caenorhabditis elegans | PR |
| Q1HE01 | Nuclear cap-binding protein subunit 2 | Bombyx mori (Silk moth) | PR | |
| Q6DES0 | ncbp2 | Nuclear cap-binding protein subunit 2 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q8JGR6 | ncbp2 | Nuclear cap-binding protein subunit 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSGGLLKALR | SDSYVELSEY | RDQHFRGDNE | EQEKLLKKSC | TLYVGNLSFY | TTEEQIYELF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SKSGDIKKII | MGLDKMKKTA | CGFCFVEYYS | RADAENAMRY | INGTRLDDRI | IRTDWDAGFK |
| 130 | 140 | 150 | |||
| EGRQYGRGRS | GGQVRDEYRE | DYDAGRGGYG | KLAQKQ |