Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q93594
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q93594-F1 | Predicted | AlphaFoldDB |
No variants for Q93594
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q93594 | |||||
No associated diseases with Q93594
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| mRNA cap binding complex | Any protein complex that binds to an mRNA cap at any time in the lifetime of the mRNA. |
| nuclear cap binding complex | A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export. |
| nuclear envelope | The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). |
| nuclear periphery | The portion of the nuclear lumen proximal to the inner nuclear membrane. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| RNA cap binding | Binding to a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| miRNA-mediated gene silencing | A post-transcriptional gene silencing pathway in which regulatory microRNAs (miRNAs) elicit silencing of specific target genes. miRNAs are endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endonucleolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA. miRNAs are present in all the animals and in plants, whereas siRNAs are present in lower animals and in plants. |
| mRNA 3'-end processing | Any process involved in forming the mature 3' end of an mRNA molecule. |
| mRNA cis splicing, via spliceosome | The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript. |
| mRNA export from nucleus | The directed movement of mRNA from the nucleus to the cytoplasm. |
| mRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
| mRNA transcription by RNA polymerase II | The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. |
| nuclear-transcribed mRNA catabolic process | The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells. |
| primary miRNA processing | A process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q08920 | CBC2 | Nuclear cap-binding protein subunit 2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q5ZKR5 | NCBP2 | Nuclear cap-binding protein subunit 2 | Gallus gallus (Chicken) | PR |
| P52298 | NCBP2 | Nuclear cap-binding protein subunit 2 | Homo sapiens (Human) | PR |
| Q9CQ49 | Ncbp2 | Nuclear cap-binding protein subunit 2 | Mus musculus (Mouse) | PR |
| B1WC40 | Ncbp2 | Nuclear cap-binding protein subunit 2 | Rattus norvegicus (Rat) | PR |
| Q1HE01 | Nuclear cap-binding protein subunit 2 | Bombyx mori (Silk moth) | PR | |
| Q6DES0 | ncbp2 | Nuclear cap-binding protein subunit 2 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q8JGR6 | ncbp2 | Nuclear cap-binding protein subunit 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVFDPRTLDN | PKEISAYRDQ | RYQGTVRDQE | TALRTSCTLY | VGNLSYYTKE | DQVYELFGRA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GDVRRVIMGL | DRFKKTPCGF | CFVEYYTRED | AELALQNISN | TRMDDRVIRA | DWDAGFIEGR |
| 130 | 140 | 150 | |||
| QYGRGKHGGQ | VRDEYRKDYD | PERGGYNRAI | AQKGGDRQ |