Q8JGR6

PR
Gene name
ncbp2 (cbp20, ch211-258l4.5)
Protein name
Nuclear cap-binding protein subunit 2
Names
20 kDa nuclear cap-binding protein, NCBP 20 kDa subunit, CBP20
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:192325
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-57 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8JGR6

Entry ID Method Resolution Chain Position Source
AF-Q8JGR6-F1 Predicted AlphaFoldDB

No variants for Q8JGR6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8JGR6

No associated diseases with Q8JGR6

No regional properties for Q8JGR6

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q8JGR6

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nuclear cap binding complex A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
RNA 7-methylguanosine cap binding Binding to a 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II.
RNA cap binding Binding to a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule.
snRNA binding Binding to a small nuclear RNA (snRNA).

9 GO annotations of biological process

Name Definition
gene silencing by RNA A process in which an RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation.
mRNA cis splicing, via spliceosome The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript.
mRNA splicing, via spliceosome The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
mRNA transport The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
positive regulation of RNA export from nucleus Any process that activates or increases the frequency, rate or extent of directed movement of RNA from the nucleus into the cytoplasm.
regulation of translation Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
RNA splicing The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
snRNA export from nucleus The directed movement of snRNA from the nucleus to the cytoplasm.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q08920 CBC2 Nuclear cap-binding protein subunit 2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q5ZKR5 NCBP2 Nuclear cap-binding protein subunit 2 Gallus gallus (Chicken) PR
P52298 NCBP2 Nuclear cap-binding protein subunit 2 Homo sapiens (Human) PR
Q9CQ49 Ncbp2 Nuclear cap-binding protein subunit 2 Mus musculus (Mouse) PR
B1WC40 Ncbp2 Nuclear cap-binding protein subunit 2 Rattus norvegicus (Rat) PR
Q93594 ncbp-2 Nuclear cap-binding protein subunit 2 Caenorhabditis elegans PR
Q1HE01 Nuclear cap-binding protein subunit 2 Bombyx mori (Silk moth) PR
Q6DES0 ncbp2 Nuclear cap-binding protein subunit 2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MSIKLNALFS DSYVDVSQYR DQHFKGNRYE QEKLLKQSAT LYVGNLSFYT TEEQVHELFA
70 80 90 100 110 120
KCGDVKRIII GLDKIKKTAC GFCFVEYYTR ADAENAMRFV NGTRLDDRII RTDWDAGFKE
130 140 150
GRQYGRGKSG GQVRDEYRQD YDPARGGYGK MVQKS