Q9CQ49
PR
Gene name |
Ncbp2 (Cbp20) |
Protein name |
Nuclear cap-binding protein subunit 2 |
Names |
20 kDa nuclear cap-binding protein, NCBP 20 kDa subunit, CBP20 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:68092 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9CQ49
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9CQ49-F1 | Predicted | AlphaFoldDB |
2 variants for Q9CQ49
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389372493 | 30 | E>* | No | EVA | |
| rs3389408360 | 140 | E>D | No | EVA |
No associated diseases with Q9CQ49
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| mRNA cap binding complex | Any protein complex that binds to an mRNA cap at any time in the lifetime of the mRNA. |
| nuclear cap binding complex | A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| RNA cap binding complex | Any protein complex that binds to a specialized RNA cap structure at any time in the lifetime of the RNA. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| RNA 7-methylguanosine cap binding | Binding to a 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II. |
| RNA cap binding | Binding to a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule. |
| snRNA binding | Binding to a small nuclear RNA (snRNA). |
16 GO annotations of biological process
| Name | Definition |
|---|---|
| alternative mRNA splicing, via spliceosome | The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition. |
| cap-dependent translational initiation | The process where the cap structure, composed of a 7- methylguanosine (m7G) group and associated cap-binding proteins, located at the 5' end of an mRNA molecule, which serves as a molecular tag that marks the spot where the 40S ribosomal subunit, is recruited and will then scan in a 5' to 3' direction until an AUG codon is encountered in an appropriate sequence context to initiate mRNA translation. |
| histone mRNA metabolic process | The chemical reactions and pathways involving an mRNA encoding a histone. |
| miRNA-mediated gene silencing | A post-transcriptional gene silencing pathway in which regulatory microRNAs (miRNAs) elicit silencing of specific target genes. miRNAs are endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endonucleolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA. miRNAs are present in all the animals and in plants, whereas siRNAs are present in lower animals and in plants. |
| mRNA 3'-end processing | Any process involved in forming the mature 3' end of an mRNA molecule. |
| mRNA cis splicing, via spliceosome | The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript. |
| mRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
| mRNA transport | The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. |
| positive regulation of phosphorylation of RNA polymerase II C-terminal domain | Any process that activates or increases the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain. |
| positive regulation of RNA export from nucleus | Any process that activates or increases the frequency, rate or extent of directed movement of RNA from the nucleus into the cytoplasm. |
| positive regulation of transcription elongation by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. |
| primary miRNA processing | A process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule. |
| regulation of translational initiation | Any process that modulates the frequency, rate or extent of translational initiation. |
| RNA splicing | The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. |
| snRNA export from nucleus | The directed movement of snRNA from the nucleus to the cytoplasm. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q08920 | CBC2 | Nuclear cap-binding protein subunit 2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q5ZKR5 | NCBP2 | Nuclear cap-binding protein subunit 2 | Gallus gallus (Chicken) | PR |
| P52298 | NCBP2 | Nuclear cap-binding protein subunit 2 | Homo sapiens (Human) | PR |
| B1WC40 | Ncbp2 | Nuclear cap-binding protein subunit 2 | Rattus norvegicus (Rat) | PR |
| Q93594 | ncbp-2 | Nuclear cap-binding protein subunit 2 | Caenorhabditis elegans | PR |
| Q1HE01 | Nuclear cap-binding protein subunit 2 | Bombyx mori (Silk moth) | PR | |
| Q6DES0 | ncbp2 | Nuclear cap-binding protein subunit 2 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q8JGR6 | ncbp2 | Nuclear cap-binding protein subunit 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSGGLLKALR | SDSYVELSEY | RDQHFRGDNE | EQEKLLKKSC | TLYVGNLSFY | TTEEQIYELF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SKSGDIKKII | MGLDKMKKTA | CGFCFVEYYS | RADAENAMRY | INGTRLDDRI | IRTDWDAGFK |
| 130 | 140 | 150 | |||
| EGRQYGRGRS | GGQVRDEYRE | DYDAGRGGYG | KLAQKQ |