Q9ZR12
PR
Gene name |
GRH1 (AFB1, FBL18, GER1, LRF1) |
Protein name |
GRR1-like protein 1 |
Names |
Protein AUXIN SIGNALING F-BOX 1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G03190 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9ZR12
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9ZR12-F1 | Predicted | AlphaFoldDB |
23 variants for Q9ZR12
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_4_1407053_C_G | 2 | G>A | No | 1000Genomes | |
| tmp_4_1407004_A_T | 18 | D>E | No | 1000Genomes | |
| tmp_4_1407006_C_T | 18 | D>N | No | 1000Genomes | |
| ENSVATH10559129 | 19 | S>A | No | 1000Genomes | |
| tmp_4_1406869_C_A | 63 | E>D | No | 1000Genomes | |
| ENSVATH06430926 | 94 | E>K | No | 1000Genomes | |
| ENSVATH02629798 | 125 | F>L | No | 1000Genomes | |
| ENSVATH10559128 | 163 | I>N | No | 1000Genomes | |
| ENSVATH06430917 | 209 | L>F | No | 1000Genomes | |
| ENSVATH10559127 | 243 | A>V | No | 1000Genomes | |
| tmp_4_1406217_T_C | 244 | Q>R | No | 1000Genomes | |
| tmp_4_1406202_G_A | 249 | A>V | No | 1000Genomes | |
| tmp_4_1406164_G_T | 262 | Q>K | No | 1000Genomes | |
| tmp_4_1406152_A_T | 266 | L>I | No | 1000Genomes | |
| tmp_4_1406104_A_T | 282 | S>T | No | 1000Genomes | |
| tmp_4_1406085_G_C | 288 | T>S | No | 1000Genomes | |
| tmp_4_1406036_C_A | 304 | E>D | No | 1000Genomes | |
| ENSVATH10559126 | 311 | K>N | No | 1000Genomes | |
| tmp_4_1405794_G_T | 358 | Q>K | No | 1000Genomes | |
| ENSVATH00457368 | 477 | E>Q | Plants were checked bi-weekly for presence of first buds and the average flowering time of 4 plants of the same accession were collected [16c and 16 hrs daylight] [EnsemblGenome] | No | 1000Genomes |
| tmp_4_1405313_G_C | 518 | A>G | No | 1000Genomes | |
| tmp_4_1405154_A_G | 571 | I>T | No | 1000Genomes | |
| ENSVATH06430903 | 581 | H>R | No | 1000Genomes |
No associated diseases with Q9ZR12
9 regional properties for Q9ZR12
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | F-box domain | 5 - 46 | IPR001810 |
| repeat | Leucine-rich repeat, cysteine-containing subtype | 100 - 124 | IPR006553-1 |
| repeat | Leucine-rich repeat, cysteine-containing subtype | 125 - 150 | IPR006553-2 |
| repeat | Leucine-rich repeat, cysteine-containing subtype | 309 - 332 | IPR006553-3 |
| repeat | Leucine-rich repeat, cysteine-containing subtype | 367 - 391 | IPR006553-4 |
| repeat | Leucine-rich repeat, cysteine-containing subtype | 427 - 450 | IPR006553-5 |
| repeat | Leucine-rich repeat, cysteine-containing subtype | 476 - 500 | IPR006553-6 |
| domain | Transport inhibitor response 1 domain | 62 - 108 | IPR041101 |
| domain | COI1, F-box | 5 - 43 | IPR041567 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| nuclear SCF ubiquitin ligase complex | A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| SCF ubiquitin ligase complex | A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| auxin binding | Binding to auxin, a plant hormone that regulates aspects of plant growth. |
| inositol hexakisphosphate binding | Binding to inositol hexakisphosphate. |
| ubiquitin-protein transferase activity | Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| auxin-activated signaling pathway | The series of molecular signals generated by the binding of the plant hormone auxin to a receptor, and ending with modulation of a downstream cellular process, e.g. transcription. |
| carbon catabolite repression of transcription by glucose | A transcription regulation process in which the presence of glucose leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances. |
| defense response | Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. |
| pollen maturation | The final stages of microgametogenesis after the trinucleate stage has been reached resulting in viable pollen grains. |
| response to auxin | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus. |
| SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8N4B4 | FBXO39 | F-box only protein 39 | Homo sapiens (Human) | PR |
| Q8N461 | FBXL16 | F-box/LRR-repeat protein 16 | Homo sapiens (Human) | PR |
| Q9UKT7 | FBXL3 | F-box/LRR-repeat protein 3 | Homo sapiens (Human) | PR |
| Q8BH70 | Fbxl4 | F-box/LRR-repeat protein 4 | Mus musculus (Mouse) | PR |
| Q8C4V4 | Fbxl3 | F-box/LRR-repeat protein 3 | Mus musculus (Mouse) | PR |
| Q9LTX2 | At5g49980 | Transport inhibitor response 1-like protein | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGLRFPPKVL | EHILSFIDSN | EDRNSVSLVC | KSWFETERKT | RKRVFVGNCY | AVSPAAVTRR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FPEMRSLTLK | GKPHFADYNL | VPDGWGGYAW | PWIEAMAAKS | SSLEEIRMKR | MVVTDECLEK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IAASFKDFKV | LVLTSCEGFS | TDGIAAIAAT | CRNLRVLELR | ECIVEDLGGD | WLSYFPESST |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SLVSLDFSCL | DSEVKISDLE | RLVSRSPNLK | SLKLNPAVTL | DGLVSLLRCA | PQLTELGTGS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FAAQLKPEAF | SKLSEAFSNC | KQLQSLSGLW | DVLPEYLPAL | YSVCPGLTSL | NLSYATVRMP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DLVELLRRCS | KLQKLWVMDL | IEDKGLEAVA | SYCKELRELR | VFPSEPDLDA | TNIPLTEQGL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VFVSKGCRKL | ESVLYFCVQF | TNAALFTIAR | KRPNLKCFRL | CVIEPFAPDY | KTNEPLDKGF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KAIAEGCRDL | RRLSVSGLLS | DKAFKYIGKH | AKKVRMLSIA | FAGDSDLMLH | HLLSGCESLK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KLEIRDCPFG | DTALLEHAAK | LETMRSLWMS | SCFVSFGACK | LLSQKMPRLN | VEVIDEHPPE |
| 550 | 560 | 570 | 580 | ||
| SRPESSPVER | IYIYRTVAGP | RMDTPEFVWT | IHKNPENGVS | HLAIK |