Q8BH70
Gene name |
Fbxl4 |
Protein name |
F-box/LRR-repeat protein 4 |
Names |
F-box and leucine-rich repeat protein 4 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:269514 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BH70
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BH70-F1 | Predicted | AlphaFoldDB |
39 variants for Q8BH70
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388655157 | 14 | F>S | No | EVA | |
| rs3388668789 | 26 | A>V | No | EVA | |
| rs3388675249 | 33 | N>Y | No | EVA | |
| rs3388668715 | 64 | H>Y | No | EVA | |
| rs3388655168 | 70 | S>N | No | EVA | |
| rs3388678534 | 71 | M>L | No | EVA | |
| rs3388663181 | 87 | S>C | No | EVA | |
| rs3388672569 | 108 | P>A | No | EVA | |
| rs3388675269 | 110 | A>S | No | EVA | |
| rs3388667206 | 116 | R>K | No | EVA | |
| rs3388661302 | 130 | T>P | No | EVA | |
| rs3388672185 | 136 | Y>* | No | EVA | |
| rs3388673446 | 145 | T>P | No | EVA | |
| rs3388672629 | 162 | Y>C | No | EVA | |
| rs3388675817 | 164 | P>S | No | EVA | |
| rs266070505 | 181 | M>T | No | EVA | |
| rs3388672146 | 209 | V>I | No | EVA | |
| rs215863542 | 231 | K>Q | No | EVA | |
| rs219249608 | 253 | E>D | No | EVA | |
| rs3388672505 | 344 | C>F | No | EVA | |
| rs3388678551 | 346 | L>H | No | EVA | |
| rs259204570 | 352 | L>M | No | EVA | |
| rs3388655199 | 378 | V>E | No | EVA | |
| rs3388674694 | 379 | R>C | No | EVA | |
| rs3388675775 | 408 | L>I | No | EVA | |
| rs3388672114 | 415 | P>T | No | EVA | |
| rs3388672660 | 419 | F>S | No | EVA | |
| rs3388663146 | 425 | L>I | No | EVA | |
| rs3388672166 | 452 | E>V | No | EVA | |
| rs3394155900 | 470 | I>M | No | EVA | |
| rs3388663180 | 483 | T>S | No | EVA | |
| rs3388661333 | 497 | I>M | No | EVA | |
| rs3388678010 | 518 | L>F | No | EVA | |
| rs27733137 | 526 | V>A | No | EVA | |
| rs249301982 | 531 | Q>K | No | EVA | |
| rs3388672542 | 546 | V>G | No | EVA | |
| rs3394015864 | 547 | C>* | No | EVA | |
| rs3394076761 | 547 | C>S | No | EVA | |
| rs3394057247 | 548 | D>H | No | EVA |
No associated diseases with Q8BH70
8 regional properties for Q8BH70
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | F-box domain | 277 - 332 | IPR001810 |
| repeat | Leucine-rich repeat, cysteine-containing subtype | 400 - 425 | IPR006553-1 |
| repeat | Leucine-rich repeat, cysteine-containing subtype | 450 - 475 | IPR006553-2 |
| repeat | Leucine-rich repeat, cysteine-containing subtype | 478 - 503 | IPR006553-3 |
| repeat | Leucine-rich repeat, cysteine-containing subtype | 504 - 524 | IPR006553-4 |
| repeat | Leucine-rich repeat, cysteine-containing subtype | 532 - 557 | IPR006553-5 |
| repeat | Leucine-rich repeat, cysteine-containing subtype | 558 - 583 | IPR006553-6 |
| repeat | Leucine-rich repeat, cysteine-containing subtype | 584 - 609 | IPR006553-7 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrial intermembrane space | The region between the inner and outer lipid bilayers of the mitochondrial envelope. |
| nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
| SCF ubiquitin ligase complex | A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| autophagy of mitochondrion | The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions. |
| SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q0VD31 | FBXL4 | F-box/LRR-repeat protein 4 | Bos taurus (Bovine) | PR |
| Q8N4B4 | FBXO39 | F-box only protein 39 | Homo sapiens (Human) | PR |
| Q9UKT7 | FBXL3 | F-box/LRR-repeat protein 3 | Homo sapiens (Human) | PR |
| Q8N461 | FBXL16 | F-box/LRR-repeat protein 16 | Homo sapiens (Human) | PR |
| Q8C4V4 | Fbxl3 | F-box/LRR-repeat protein 3 | Mus musculus (Mouse) | PR |
| Q9ZR12 | GRH1 | GRR1-like protein 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LTX2 | At5g49980 | Transport inhibitor response 1-like protein | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSPVFPMLTV | LTMFYYMCLR | RRARTATRGD | MMNSHRTIVS | NSRTSPLNAE | VVQYAKEVVD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FSSHYGSENS | MSYTMWNLAG | VPNVFPSSGD | FTQTAVFRTY | GTWWDQCPSA | SLPFRRTPSS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FQSQDYVELT | FEQQVYPTAV | HVLETYHPGA | VIRILACSAN | PYSPNPPAEV | RWEILWSERP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MKVNASQARQ | FKPCIKQINF | PTNLIRLEVN | SSLLDYYTEL | DAVVLHGTKD | KPLLSLKTAL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VDMNDLEDDD | YEEKDGCEMD | ALNKKFSSAA | LGDGPHNGYF | DKLPYELIQL | ILNHLSLPDL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CRLAQTCRLL | HQHCCDPLQY | IHLNLQPYWA | RLDDTSLEFL | QARCVLVQWL | NLSWTGNRGF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ISVSGFSRFL | KVCGSELVRL | ELSCSHFLND | TCLEVISEMC | PNLQDLNLSS | CDKLPPQAFG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| HIAKLCSLKR | LVLYRTKVEQ | TALLSILNFC | AELQHLSLGS | CVMIEDYDVI | ASMIGAKCKN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LRTLDLWRCK | NITENGIAEL | ASGCVLLEEL | DLGWCPTLQS | STGCFVRLAR | QLPNLQKLFL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TANRSVCDTD | IEELASNCTR | LQQLDILGTR | MVSPASLRKL | LESCKDLSLL | DVSFCSQIDN |
| 610 | 620 | ||||
| KAVLELNASF | PKVFIKKSFT | Q |