Q9Y169

PR
Gene name
sotv
Protein name
Exostosin-2
Names
Protein sister of tout-velu
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG8433
EC number
2.4.1.224: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

469-543 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9Y169

Entry ID Method Resolution Chain Position Source
AF-Q9Y169-F1 Predicted AlphaFoldDB

No variants for Q9Y169

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9Y169

No associated diseases with Q9Y169

2 regional properties for Q9Y169

Type Name Position InterPro Accession
domain Glycosyl transferase 64 domain 455 - 700 IPR015338
domain Exostosin, GT47 domain 106 - 377 IPR040911

Functions

Description
EC Number 2.4.1.224 Hexosyltransferases
Subcellular Localization
  • Endoplasmic reticulum membrane ; Single-pass type II membrane protein
  • Golgi apparatus membrane ; Single-pass type II membrane protein
  • Localization to the Golgi may be regulated by sau (PubMed:23720043)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

5 GO annotations of molecular function

Name Definition
acetylglucosaminyltransferase activity Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar.
glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity Catalysis of the reaction: beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP-N-acetyl-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP.
glycosyltransferase activity Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
metal ion binding Binding to a metal ion.
N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity Catalysis of the reaction: N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP.

11 GO annotations of biological process

Name Definition
chondroitin sulfate biosynthetic process The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate.
glycosaminoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars.
heparan sulfate proteoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharide chain component of heparan sulfate proteoglycan.
heparin biosynthetic process The chemical reactions and pathways resulting in the formation of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
N-acetylglucosamine metabolic process The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein.
positive regulation of BMP signaling pathway Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity.
positive regulation of canonical Wnt signaling pathway Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
positive regulation of smoothened signaling pathway Any process that activates or increases the frequency, rate or extent of smoothened signaling.
protein glycosylation A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.
Wnt signaling pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O77783 EXT2 Exostosin-2 Bos taurus (Bovine) PR
Q9ES89 Extl2 Exostosin-like 2 Mus musculus (Mouse) PR
P70428 Ext2 Exostosin-2 Mus musculus (Mouse) PR
Q9LFP3 At5g11130/At5g11120 Probable glycosyltransferase At5g11130 Arabidopsis thaliana (Mouse-ear cress) PR
Q94AA9 XGD1 Xylogalacturonan beta-1,3-xylosyltransferase Arabidopsis thaliana (Mouse-ear cress) PR
Q3EAR7 At3g42180 Probable glycosyltransferase At3g42180 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MTKIKNLLSF VTQSRAISHT NPREHILNCL TYGLLVIVAL CAGFLLWDLS SSPRDGFFHG
70 80 90 100 110 120
KRDSHTLILD LEHIQELAVN PEAEQRARNV NCTFWDCLNI YKCEHDRLKV YIYPLQEFVD
130 140 150 160 170 180
EQSDKTATTL SSEYFQILEA VLKSRYYTSN PNEACLFLPS LDLLNQNVFD KHLAGAALAS
190 200 210 220 230 240
LDFWDRGANH IIFNMLPGGA PSYNTVLDVN TDNAIIFGGG FDSWSYRPGF DVAIPVWSPR
250 260 270 280 290 300
LVRQHAHATA QRKFLLVVAQ LNILPRFVRT LRELSLAHSE QLLLLGACEN LDLTMRCPLS
310 320 330 340 350 360
QHHKSLEYPR LLSRGKFCLL GRSLRMGQPD LVEIMSQHCI PVIAVDNYVL PFEDVIDWSL
370 380 390 400 410 420
ASVRIRENEL HSVMQKLKAI SSVKIVEMQK QVQWLFSKYF KDLKTVTLTA LEVLESRIFP
430 440 450 460 470 480
LRARSSRQWN TIDTNARSTF NPLFLPSLAP KSQGFTAVIL TYDRVESLFL LIQKLAVVPS
490 500 510 520 530 540
LQSILVIWNN QKKSPPHLST FPSISKPLKI RQTKENKLSN RFYPYPEIET EAILTIDDDI
550 560 570 580 590 600
IMLTTDELDF GYEVWREFPD HIVGFPSRIH VWENVTMRWH YESEWTNQIS MVLTGAAFHH
610 620 630 640 650 660
KYWSHMYTHA MPGDIKDWVD EHMNCEDIAM NFLVANITNN PPIKVTPRKK FKCPECTNTE
670 680 690 700 710
MLSADLNHMR ERSACIDRFS KIYGRMPLRT VEFRADPVLF RDNFPDKLKR YNDIGSL