Q9ES89
Gene name |
Extl2 (Extr2) |
Protein name |
Exostosin-like 2 |
Names |
Alpha-1,4-N-acetylhexosaminyltransferase EXTL2, Alpha-GalNAcT EXTL2, EXT-related protein 2, Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:58193 |
EC number |
2.4.1.223: Hexosyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
5 structures for Q9ES89
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1OMX | X-ray | 240 A | A/B | 38-330 | PDB |
| 1OMZ | X-ray | 210 A | A/B | 38-330 | PDB |
| 1ON6 | X-ray | 230 A | A/B | 38-330 | PDB |
| 1ON8 | X-ray | 270 A | A/B | 38-330 | PDB |
| AF-Q9ES89-F1 | Predicted | AlphaFoldDB |
13 variants for Q9ES89
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388657299 | 14 | V>A | No | EVA | |
| rs3388660620 | 15 | M>V | No | EVA | |
| rs3393313288 | 18 | R>* | No | EVA | |
| rs3388654803 | 21 | R>W | No | EVA | |
| rs864307862 | 22 | F>I | No | EVA | |
| rs3388654359 | 25 | V>A | No | EVA | |
| rs3388642246 | 39 | N>I | No | EVA | |
| rs3388654787 | 45 | K>R | No | EVA | |
| rs225448158 | 51 | T>S | No | EVA | |
| rs247771885 | 92 | S>N | No | EVA | |
| rs30136104 | 176 | I>V | No | EVA | |
| rs13472796 | 191 | Y>D | No | EVA | |
| rs3388654424 | 304 | Y>H | No | EVA |
No associated diseases with Q9ES89
1 regional properties for Q9ES89
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Glycosyl transferase 64 domain | 67 - 321 | IPR015338 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.4.1.223 | Hexosyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| alpha-1,4-N-acetylgalactosaminyltransferase activity | Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming an alpha-1,4 linkage. |
| glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan. |
| glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity | Catalysis of the reaction: D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP. |
| glycosaminoglycan binding | Binding to a glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues. |
| manganese ion binding | Binding to a manganese ion (Mn). |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| N-acetylglucosamine metabolic process | The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein. |
| protein glycosylation | A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. |
| UDP-N-acetylgalactosamine metabolic process | The chemical reactions and pathways involving UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MMRGCHICKL | PGRVMGIRVL | RFSLVVILVL | LLVAGALTNL | LPNIKEDKML | TLRREIKSPS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KSALDSFTLI | MQTYNRTDLL | LRLLNHYQAV | PSLHKVIVVW | NNVGEKGPEE | LWNSLGPHPI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PVIFKPQTAN | KMRNRLQVFP | EVETNAVLMV | DDDTLISAQD | LVFAFSIWQQ | FPDQIIGFVP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RKHVSTSSGI | YSYGGFELQT | PGPGNGDQYS | MVLIGASFFN | SKYLELFQKQ | PAAVHALIDE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TQNCDDIAMN | FLVTRHTGKP | SGIFVKPINM | VNLEKETNGY | SGMWHRAEHF | LQRSYCINKL |
| 310 | 320 | ||||
| VNIYDGMPLK | YSNIMISQFG | FPYANHKSKM |