Q9WVL6

PR
Gene name
Extl3
Protein name
Exostosin-like 3
Names
Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase, Multiple exostosis-like protein 3
Species
Mus musculus (Mouse)
KEGG Pathway
EC number
2.4.1.223: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

110-196 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9WVL6

Entry ID Method Resolution Chain Position Source
AF-Q9WVL6-F1 Predicted AlphaFoldDB

No variants for Q9WVL6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9WVL6

No associated diseases with Q9WVL6

2 regional properties for Q9WVL6

Type Name Position InterPro Accession
domain Glycosyl transferase 64 domain 662 - 903 IPR015338
domain Exostosin, GT47 domain 191 - 499 IPR040911

Functions

Description
EC Number 2.4.1.223 Hexosyltransferases
Subcellular Localization
  • Endoplasmic reticulum membrane ; Single-pass type II membrane protein
  • Golgi apparatus
  • Cell membrane
  • Nucleus
  • Interaction with REG3A induces its translocation to the nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

3 GO annotations of molecular function

Name Definition
glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan.
glycosyltransferase activity Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
metal ion binding Binding to a metal ion.

3 GO annotations of biological process

Name Definition
heparan sulfate proteoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.
positive regulation of cell growth Any process that activates or increases the frequency, rate, extent or direction of cell growth.
protein glycosylation A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O43909 EXTL3 Exostosin-like 3 Homo sapiens (Human) PR
P70428 Ext2 Exostosin-2 Mus musculus (Mouse) PR
P97464 Ext1 Exostosin-1 Mus musculus (Mouse) PR
Q94AA9 XGD1 Xylogalacturonan beta-1,3-xylosyltransferase Arabidopsis thaliana (Mouse-ear cress) PR
Q3EAR7 At3g42180 Probable glycosyltransferase At3g42180 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LFP3 At5g11130/At5g11120 Probable glycosyltransferase At5g11130 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MTGYTMLRNG GVGNGGQTCM LRWSNRIRLT WLSFTLFIIL VFFPLIAHYY LTTLDEADEA
70 80 90 100 110 120
GKRIFGPRAG SELCEVKHVL DLCRIRESVS EELLQLEAKR QELNSEIAKL NLKIEACKKS
130 140 150 160 170 180
IENAKQDLLQ LKNVISQTEH SYKELMAQNQ PKLSLPIRLL PEKDDAGLPP PKVTRGCRLH
190 200 210 220 230 240
NCFDYSRCPL TSGFPVYVYD SDQFAFGSYL DPLVKQAFQA TVRANVYVTE NAAIACLYVV
250 260 270 280 290 300
LVGEMQEPTV LRPADLEKQL FSLPHWRTDG HNHVIINLSR KSDTQNLLYN VSTGRHVAQS
310 320 330 340 350 360
TFYAAQYRAG FDLVVSPLVH AMSEPNFMEI PPQVPVKRKY LFTFQGEKIE SLRSSLQEAR
370 380 390 400 410 420
SFEEEMEGDP PADYDDRIIA TLKAVQDSKL DQVLVEFTCK NQPKPSLPTE WALCGEREDR
430 440 450 460 470 480
LELLKLSTFA LIITPGDPHL LISSGCATRL FEALEVGAVP VVLGEQVQLP YHDMLQWNEA
490 500 510 520 530 540
ALVVPKPRVT EVHFLLRSLS DSDLLAMRRQ GRFLWETYFS TADSIFNTVL AMIRTRIQIP
550 560 570 580 590 600
AAPIREEVAA EIPHRSGKAA GTDPNMADNG DLDLGPVETE PPYASPKYLR NFTLTVTDCY
610 620 630 640 650 660
RGWNSAPGPF HLFPHTPFDP VLPSEAKFLG SGTGFRPIGG GAGGSGKEFQ AALGGNVQRE
670 680 690 700 710 720
QFTVVMLTYE REEVLMNSLE RLNGLPYLNK VVVVWNSPKL PSEDLLWPDI GVPIMVVRTE
730 740 750 760 770 780
KNSLNNRFLP WNEIETEAIL SIDDDAHLRH DEIMFGFRVW REARDRIVGF PGRYHAWDIP
790 800 810 820 830 840
HQSWLYNSNY SCELSMVLTG AAFFHKYYAY LYSYVMPQAI RDMVDEYINC EDIAMNFLVS
850 860 870 880 890 900
HITRKPPIKV TSRWTFRCPG CPQALSHDDS HFHERHKCIN FFVKVYGYMP LLYTQFRVDS
910
VLFKTRLPHD KTKCFKFI