Q9WVL0
Gene name |
Gstz1 (Maai) |
Protein name |
Maleylacetoacetate isomerase |
Names |
MAAI, GSTZ1-1, Glutathione S-transferase zeta 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:14874 |
EC number |
2.5.1.18: Transferring alkyl or aryl groups, other than methyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for Q9WVL0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2CZ2 | X-ray | 140 A | A | 1-216 | PDB |
| 2CZ3 | X-ray | 230 A | A/B | 1-216 | PDB |
| AF-Q9WVL0-F1 | Predicted | AlphaFoldDB |
13 variants for Q9WVL0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3403454368 | 16 | C>* | No | EVA | |
| rs3403608903 | 16 | C>S | No | EVA | |
| rs3403546145 | 18 | W>N | No | EVA | |
| rs8259779 | 70 | V>G | No | EVA | |
| rs3389249323 | 81 | E>G | No | EVA | |
| rs51729137 | 96 | R>K | No | EVA | |
| rs3389225795 | 110 | I>F | No | EVA | |
| rs3403541566 | 116 | L>M | No | EVA | |
| rs3389267131 | 118 | V>D | No | EVA | |
| rs3389262470 | 130 | W>* | No | EVA | |
| rs8259789 | 137 | S>A | No | EVA | |
| rs3389237512 | 176 | F>I | No | EVA | |
| rs3403855521 | 217 | T>Y | No | EVA |
No associated diseases with Q9WVL0
5 regional properties for Q9WVL0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Glutathione S-transferase, N-terminal | 4 - 87 | IPR004045 |
| domain | Glutathione S-transferase, C-terminal | 125 - 187 | IPR004046 |
| domain | Glutathione S-transferase, C-terminal-like | 92 - 212 | IPR010987 |
| domain | Glutathione S-transferases, class Zeta, C-terminal | 93 - 207 | IPR034330 |
| domain | Glutathione S-transferases, class Zeta, N-terminal | 6 - 80 | IPR034333 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.5.1.18 | Transferring alkyl or aryl groups, other than methyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| glutathione transferase activity | Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. |
| identical protein binding | Binding to an identical protein or proteins. |
| maleylacetoacetate isomerase activity | Catalysis of the reaction: 4-maleylacetoacetate = 4-fumarylacetoacetate. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| glutathione metabolic process | The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle. |
| L-phenylalanine catabolic process | The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. |
| tyrosine catabolic process | The chemical reactions and pathways resulting in the breakdown of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9ZW30 | GSTU1 | Glutathione S-transferase U1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P46421 | GSTU5 | Glutathione S-transferase U5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FUS9 | GSTU18 | Glutathione S-transferase U18 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZVQ3 | GSTZ1 | Glutathione S-transferase Z1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQAGKPILYS | YFRSSCSWRV | RIALALKGID | YEIVPINLIK | DGGQQFTEEF | QTLNPMKQVP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ALKIDGITIV | QSLAIMEYLE | ETRPIPRLLP | QDPQKRAIVR | MISDLIASGI | QPLQNLSVLK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QVGQENQMQW | AQKVITSGFN | ALEKILQSTA | GKYCVGDEVS | MADVCLVPQV | ANAERFKVDL |
| 190 | 200 | 210 | |||
| SPYPTISHIN | KELLALEVFQ | VSHPRRQPDT | PAELRT |