Q9ZVQ3

PR
Gene name
GSTZ1 (GST18, GSTZ, At2g02390, T16F16.18)
Protein name
Glutathione S-transferase Z1
Names
AtGSTZ1, GST class-zeta member 1, Glutathione S-transferase 18, Maleylacetone isomerase, MAI
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT2G02390
EC number
2.5.1.18: Transferring alkyl or aryl groups, other than methyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

171-221 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q9ZVQ3

Entry ID Method Resolution Chain Position Source
1E6B X-ray 165 A A 1-221 PDB
AF-Q9ZVQ3-F1 Predicted AlphaFoldDB

32 variants for Q9ZVQ3

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH10654119 12 Y>C No 1000Genomes
tmp_2_629185_C_G 25 I>M No 1000Genomes
ENSVATH05216921 26 A>T No 1000Genomes
ENSVATH01613925 32 L>I No 1000Genomes
tmp_2_629300_T_G 32 L>R No 1000Genomes
ENSVATH05216924 36 Y>H No 1000Genomes
tmp_2_629336_G_A 44 G>D No 1000Genomes
tmp_2_629342_A_G 46 Q>R No 1000Genomes
tmp_2_629351_C_T 49 S>L No 1000Genomes
ENSVATH05216926 71 N>S No 1000Genomes
ENSVATH01613932 93 D>G No 1000Genomes
ENSVATH01613933 99 V>M No 1000Genomes
ENSVATH00202024 103 A>G No 1000Genomes
ENSVATH10654649 134 A>V No 1000Genomes
tmp_2_630144_G_A 139 A>T No 1000Genomes
ENSVATH01613938 141 T>S No 1000Genomes
ENSVATH05216957 155 A>D No 1000Genomes
ENSVATH05216957 155 A>G No 1000Genomes
ENSVATH05216958 158 H>L No 1000Genomes
tmp_2_630357_G_C 161 G>A No 1000Genomes
ENSVATH10654890 172 A>S No 1000Genomes
tmp_2_630557_C_A 176 H>N No 1000Genomes
tmp_2_630564_C_G 178 A>G No 1000Genomes
ENSVATH05216979 191 T>N No 1000Genomes
ENSVATH05216980 197 E>G No 1000Genomes
tmp_2_630878_G_C 197 E>Q No 1000Genomes
ENSVATH10655235 200 N>D No 1000Genomes
ENSVATH05216981 200 N>K No 1000Genomes
ENSVATH05216982 204 A>V No 1000Genomes
tmp_2_630911_G_A 208 A>T No 1000Genomes
tmp_2_630938_CCTT_ACTT,C 217 P>T No 1000Genomes
tmp_2_630951_T_A 221 I>N No 1000Genomes

No associated diseases with Q9ZVQ3

3 regional properties for Q9ZVQ3

Type Name Position InterPro Accession
domain Transcription factor IIIC, 90kDa subunit, N-terminal 64 - 254 IPR024761
domain Transcription factor IIIC, putative zinc-finger 739 - 790 IPR024764
domain Domain of unknown function DUF5921 265 - 720 IPR045803

Functions

Description
EC Number 2.5.1.18 Transferring alkyl or aryl groups, other than methyl groups
Subcellular Localization
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
glutathione transferase activity Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
maleylacetoacetate isomerase activity Catalysis of the reaction: 4-maleylacetoacetate = 4-fumarylacetoacetate.
peroxidase activity Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O.

4 GO annotations of biological process

Name Definition
glutathione metabolic process The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
homogentisate catabolic process The chemical reactions and pathways resulting in the breakdown of homogentisate.
L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid.
toxin catabolic process The chemical reactions and pathways resulting in the breakdown of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9WVL0 Gstz1 Maleylacetoacetate isomerase Mus musculus (Mouse) PR
10 20 30 40 50 60
MANSGEEKLK LYSYWRSSCA HRVRIALALK GLDYEYIPVN LLKGDQFDSD FKKINPMGTV
70 80 90 100 110 120
PALVDGDVVI NDSFAIIMYL DEKYPEPPLL PRDLHKRAVN YQAMSIVLSG IQPHQNLAVI
130 140 150 160 170 180
RYIEEKINVE EKTAWVNNAI TKGFTALEKL LVNCAGKHAT GDEIYLADLF LAPQIHGAIN
190 200 210 220
RFQINMEPYP TLAKCYESYN ELPAFQNALP EKQPDAPSST I