Q9VYA0

PR
Gene name
Nadsyn
Protein name
Glutamine-dependent NAD(+) synthetase
Names
NAD(+) synthase [glutamine-hydrolyzing]
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG9940
EC number
6.3.5.1: Carbon--nitrogen ligases with glutamine as amido-N-donor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

671-769 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9VYA0

Entry ID Method Resolution Chain Position Source
AF-Q9VYA0-F1 Predicted AlphaFoldDB

No variants for Q9VYA0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9VYA0

No associated diseases with Q9VYA0

2 regional properties for Q9VYA0

Type Name Position InterPro Accession
domain Carbon-nitrogen hydrolase 5 - 282 IPR003010
domain NAD/GMP synthase 339 - 602 IPR022310

Functions

Description
EC Number 6.3.5.1 Carbon--nitrogen ligases with glutamine as amido-N-donor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
glutaminase activity Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3.
NAD+ synthase (glutamine-hydrolyzing) activity Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate.

2 GO annotations of biological process

Name Definition
NAD biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH.
negative regulation of neuromuscular synaptic transmission Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular synaptic transmission.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q711T7 Nadsyn1 Glutamine-dependent NAD(+) synthetase Mus musculus (Mouse) PR
Q812E8 Nadsyn1 Glutamine-dependent NAD(+) synthetase Rattus norvegicus (Rat) PR
Q0D8D4 Os07g0167100 Glutamine-dependent NAD(+) synthetase Oryza sativa subsp japonica (Rice) PR
Q9C723 At1g55090 Glutamine-dependent NAD(+) synthetase Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MGRKVTVAVS TLNQWALDFE GNMVRILQSI LEAKDMGASY RTGPELEVCG YSCEDHFREP
70 80 90 100 110 120
DTFLHSWEVL LEVMMSPMCE NMLVDVGMPV MHRNVAYNCR VAFFNRQILL IRPKMAMCDD
130 140 150 160 170 180
GNYRESRWFT AWTKALQTEE YVLPRMIAQH TGQQTVPFGD AVIATRDTCL GYEICEELWN
190 200 210 220 230 240
VRSKHIEMSL AGVELIVNSS GSYMELRKAH ITSDLIRNAS FKAGGAYLFS NLRGCDGQRV
250 260 270 280 290 300
YFNGCSAIAL NGEILARSQQ FALQDVEVTL ATIDLEEIRA YRVSLRSRCT AAASAAEYPR
310 320 330 340 350 360
IHCDFEMSTH SDIFKTSTPP LNWPMHTPEE EIALGPACWL WDYLRRSGQG GFFLPLSGGV
370 380 390 400 410 420
DSSSSATIVH SMCRQIVQAV QQGDAQVLHD IRQLLADSDY TPDNAAGLCN RLLVTCYMGS
430 440 450 460 470 480
VNSSKETRRR AAQLANQLGS YHIEISIDSA VNALLSIFNA VTGLTPRFRT QGGCARQNLA
490 500 510 520 530 540
LQNMQSRIRM VLAYIFAQLT LWVRNRPGGL LVLGSANVDE SLRGYLTKYD CSSADINPIG
550 560 570 580 590 600
GISKMDLRRF LTYAKDKFNL PVLESIIDAP PTAELEPLQE NGELQQTDEA DMGMTYAELS
610 620 630 640 650 660
QFGRLRKQSF CGPYSMFCHL VATWKSDLSP KEVAEKVKHF FLCYAINRHK MTVLTPSVHA
670 680 690 700 710 720
ESYSPDDNRF DHRPFLYRPN WSWQFKAIDD EAEKLQPIYT PSSAQLRPSS EDLLISTQRS
730 740 750 760 770 780
SHLDDSKHSS PLSSASASAS IDVGISTAAV PLPGAAAPGG LSKKPSGYSK VHVNVLGKIK
DRTGIPV