AiPD: Autoinhibited Protein Database

Gene name	At1g55090 (T7N22.4)
Protein name	Glutamine-dependent NAD(+) synthetase
Names	NAD(+) synthase [glutamine-hydrolyzing], NAD(+) synthetase
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT1G55090
EC number	6.3.5.1: Carbon--nitrogen ligases with glutamine as amido-N-donor
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

665-725 (Predicted disordered autoinhibitory region) PR

665-725 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9C723-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH13577483	35	A>T	No	1000Genomes
ENSVATH00098271	76	D>V	No	1000Genomes
ENSVATH14320566	134	R>K	No	1000Genomes
ENSVATH13577488	145	E>K	No	1000Genomes
ENSVATH04966470	156	P>S	No	1000Genomes
tmp_1_20555495_G_A	160	G>S	No	1000Genomes
ENSVATH04966471	186	E>K	No	1000Genomes
tmp_1_20555686_G_T	196	M>I	No	1000Genomes
ENSVATH13577490	214	A>V	No	1000Genomes
tmp_1_20555927_G_C	244	C>S	No	1000Genomes
ENSVATH01372462	252	N>D	No	1000Genomes
ENSVATH13577491	304	C>Y	No	1000Genomes
ENSVATH04966475	315	T>I	No	1000Genomes
tmp_1_20556656_C_T	397	A>V	No	1000Genomes
tmp_1_20556688_T_C	408	F>L	No	1000Genomes
tmp_1_20556705_T_A	413	F>L	No	1000Genomes
tmp_1_20556704_T_C	413	F>S	No	1000Genomes
ENSVATH01372472	432	K>T	No	1000Genomes
tmp_1_20556941_A_T	457	L>F	No	1000Genomes
tmp_1_20556962_G_T	464	K>N	No	1000Genomes
ENSVATH13577510	476	A>G	No	1000Genomes
tmp_1_20557180_C_T	499	L>F	No	1000Genomes
ENSVATH00098283	559	G>R	No	1000Genomes
tmp_1_20557515_A_T	582	Y>F	No	1000Genomes
tmp_1_20557686_G_A	612	V>I	No	1000Genomes
tmp_1_20558078_G_A	690	V>I	No	1000Genomes
tmp_1_20558103_T_A	698	V>D	No	1000Genomes
ENSVATH13577528	708	N>S	No	1000Genomes
tmp_1_20558142_T_C	711	I>T	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Carbon-nitrogen hydrolase	4 - 281	IPR003010
domain	NAD/GMP synthase	338 - 598	IPR022310

		Description
EC Number	6.3.5.1	Carbon--nitrogen ligases with glutamine as amido-N-donor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
glutaminase activity	Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3.
NAD+ synthase (glutamine-hydrolyzing) activity	Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate.

Name	Definition
NAD biosynthetic process	The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9VYA0	Nadsyn	Glutamine-dependent NAD(+) synthetase	Drosophila melanogaster (Fruit fly)	PR
Q711T7	Nadsyn1	Glutamine-dependent NAD(+) synthetase	Mus musculus (Mouse)	PR
Q812E8	Nadsyn1	Glutamine-dependent NAD(+) synthetase	Rattus norvegicus (Rat)	PR
Q0D8D4	Os07g0167100	Glutamine-dependent NAD(+) synthetase	Oryza sativa subsp japonica (Rice)	PR