Q812E8

PR
Gene name
Nadsyn1 (Qns1)
Protein name
Glutamine-dependent NAD(+) synthetase
Names
NAD(+) synthase [glutamine-hydrolyzing], NAD(+) synthetase
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:353255
EC number
6.3.5.1: Carbon--nitrogen ligases with glutamine as amido-N-donor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

542-618 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q812E8

Entry ID Method Resolution Chain Position Source
AF-Q812E8-F1 Predicted AlphaFoldDB

No variants for Q812E8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q812E8

No associated diseases with Q812E8

2 regional properties for Q812E8

Type Name Position InterPro Accession
domain Carbon-nitrogen hydrolase 5 - 282 IPR003010
domain NAD/GMP synthase 339 - 598 IPR022310

Functions

Description
EC Number 6.3.5.1 Carbon--nitrogen ligases with glutamine as amido-N-donor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
glutaminase activity Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3.
NAD+ synthase (glutamine-hydrolyzing) activity Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate.

2 GO annotations of biological process

Name Definition
'de novo' NAD biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of tryptophan or aspartate from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH.
NAD biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9VYA0 Nadsyn Glutamine-dependent NAD(+) synthetase Drosophila melanogaster (Fruit fly) PR
Q711T7 Nadsyn1 Glutamine-dependent NAD(+) synthetase Mus musculus (Mouse) PR
Q0D8D4 Os07g0167100 Glutamine-dependent NAD(+) synthetase Oryza sativa subsp japonica (Rice) PR
Q9C723 At1g55090 Glutamine-dependent NAD(+) synthetase Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MGRKVTVATC ALNQWALDFE GNFQRILKSI QIAKGKGARY RLGPELEICG YGCWDHYHES
70 80 90 100 110 120
DTLLHSLQVL AALLDAPATQ DIICDVGMPI MHRNVRYNCL VIFLNRKILL IRPKMALANE
130 140 150 160 170 180
GNYRELRWFT PWARSRQTEE YVLPRMLQDL TKQETVPFGD VVLATQDTCI GSEICEELWT
190 200 210 220 230 240
PCSPHVNMGL DGVEIITNAS GSHHVLRKAH TRVDLVTMAT SKNGGIYLLA NQKGCDGHLL
250 260 270 280 290 300
YYDGCAMIAM NGSIFAQGTQ FSLDDVEVLT ATLDLEDVRS YRAKISSRNL EATRVNPYPR
310 320 330 340 350 360
VTVDFALSVS EDLLEPVSEP VEWTYHRPEE EISLGPACWL WDFLRRNNQA GFFLPLSGGV
370 380 390 400 410 420
DSAASACVVY SMCCLVCEAV KSGNQQVLTD VQNLVDESSY TPQDPRELCG RLLTTCYMAS
430 440 450 460 470 480
ENSSQETHNR ATELAQQIGS YHISLNIDPA VKAILGIFSL VTGKFPRFSA HGGSSRENLA
490 500 510 520 530 540
LQNVQARIRM VLAYLFAQLS LWSRGARGSL LVLGSANVDE SLLGYLTKYD CSSADINPIG
550 560 570 580 590 600
GISKTDLRAF VQLCAERFQL PVLQAILSAP ATAELEPLAD GQVSQMDEED MGMTYTELSI
610 620 630 640 650 660
FGRLRKVAKA GPYSMFCKLL NMWKDSCTPR QVAEKVKRFF SKYSINRHKM TTLTPAYHAE
670 680 690 700 710 720
NYSPDDNRFD LRPFLYNTRW PWQFLCIDNQ VVQLERKTSQ TLEEQIQEHF KEPSPIWKQL
LPKDP