Q0D8D4

PR
Gene name
Os07g0167100 (LOC_Os07g07260)
Protein name
Glutamine-dependent NAD(+) synthetase
Names
NAD(+) synthase [glutamine-hydrolyzing], NAD(+) synthetase
Species
Oryza sativa subsp japonica (Rice)
KEGG Pathway
osa:4342490
EC number
6.3.5.1: Carbon--nitrogen ligases with glutamine as amido-N-donor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

670-735 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q0D8D4

Entry ID Method Resolution Chain Position Source
AF-Q0D8D4-F1 Predicted AlphaFoldDB

No variants for Q0D8D4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q0D8D4

No associated diseases with Q0D8D4

2 regional properties for Q0D8D4

Type Name Position InterPro Accession
domain Carbon-nitrogen hydrolase 4 - 281 IPR003010
domain NAD/GMP synthase 338 - 598 IPR022310

Functions

Description
EC Number 6.3.5.1 Carbon--nitrogen ligases with glutamine as amido-N-donor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
glutaminase activity Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3.
NAD+ synthase (glutamine-hydrolyzing) activity Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate.

1 GO annotations of biological process

Name Definition
NAD biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9VYA0 Nadsyn Glutamine-dependent NAD(+) synthetase Drosophila melanogaster (Fruit fly) PR
Q711T7 Nadsyn1 Glutamine-dependent NAD(+) synthetase Mus musculus (Mouse) PR
Q812E8 Nadsyn1 Glutamine-dependent NAD(+) synthetase Rattus norvegicus (Rat) PR
Q9C723 At1g55090 Glutamine-dependent NAD(+) synthetase Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MRLLRVATCN LNQWAMDFDT NLRNVKESIA RAKAAGAAVR VGPELELTGY GCEDHFLEQD
70 80 90 100 110 120
TAAHAWECLK DILSGGYTDG ILCSIGMPVI FKSVRYNCQV FCLNSKIVMI RPKISLANDG
130 140 150 160 170 180
NYREFRWFSA WTFKDALVDF QLPLDISEVT SQDTVPFGYG FIQFLDVSLA SETCEELFTA
190 200 210 220 230 240
NAPRIDLALN GVEVFVNASG SHHQLRKLSL RIDSMRNATL ACGGVYMYAN QQGCDGGRLY
250 260 270 280 290 300
YDGCCCIAVN GDVVAQGSQF SLKDVEVLDA LVDLDAVSSY RASVSSFREQ ASHRTKVPFV
310 320 330 340 350 360
KVPYKLCKPF QSGMVPTGPV EVMYHRPEEE IAFGPSCWLW DYLRRSRASG FLLPLSGGAD
370 380 390 400 410 420
SSSVAAIVGC MCQLVVKDIE NGDEQVKADA MRIGQYKDGE FPKDSRELAK RLFYTVYMGT
430 440 450 460 470 480
ENSSEGTRSR AKMLAEEIGS FHLDVPIDSI VSALLSLFER LTGKRPRYKV DGGSNTENLG
490 500 510 520 530 540
LQNIQARIRM VLAFMMASLM PWVHNKSGFY LVLGSSNVDE GLRGYLTKYD CSSADINPIG
550 560 570 580 590 600
SVSKQDLRAF LRWAAVHLHY SSLAEVEAAP PTAELEPIRA DYNQLDEVDM GMTYEELSIY
610 620 630 640 650 660
GRLRKIFRCG PVSMFQNLCH RWCGTLSPSE VADKVKHFFK YYAINRHKMT VLTPSYHAES
670 680 690 700 710 720
YSPEDNRFDL RQFLYNARWP YQFRKIDELV QDMDKDGKWV NSTEGELRRR KGVRSAEGGG
730
MGVVAVGSAN PSAGS