Q711T7

PR
Gene name
Nadsyn1
Protein name
Glutamine-dependent NAD(+) synthetase
Names
NAD(+) synthase [glutamine-hydrolyzing], NAD(+) synthetase, NH3-dependent NAD(+) synthetase-like protein
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:78914
EC number
6.3.5.1: Carbon--nitrogen ligases with glutamine as amido-N-donor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

540-616 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q711T7

Entry ID Method Resolution Chain Position Source
AF-Q711T7-F1 Predicted AlphaFoldDB

56 variants for Q711T7

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3398670244 6 T>S No EVA
rs3388966545 12 L>I No EVA
rs3388947435 17 L>M No EVA
rs3388919298 26 I>M No EVA
rs3388940985 48 I>K No EVA
rs3388947497 50 G>D No EVA
rs3388935622 51 Y>* No EVA
rs3388965298 52 G>V No EVA
rs3388963419 57 Y>D No EVA
rs3388966568 109 L>Q No EVA
rs3388958766 169 C>Y No EVA
rs218798877 186 I>V No EVA
rs3388958805 191 D>N No EVA
rs3388969924 208 K>* No EVA
rs3388969924 208 K>E No EVA
rs247805404 225 G>S No EVA
rs217533602 241 Y>H No EVA
rs13465608 249 A>G No EVA
rs3388969898 264 D>V No EVA
rs3388935539 272 T>I No EVA
rs248734300 282 K>R No EVA
rs3388965321 285 I>N No EVA
rs3388961506 290 L>P No EVA
rs247321994 321 M>I No EVA
rs3388940989 354 L>H No EVA
rs3388965231 364 A>V No EVA
rs3388963586 373 C>Y No EVA
rs3388961458 378 D>G No EVA
rs3388959685 386 Q>* No EVA
rs3388959639 387 V>E No EVA
rs3388953338 412 L>M No EVA
rs3388966193 426 E>D No EVA
rs3388966194 446 S>I No EVA
rs36612792 461 M>V No EVA
rs3388919326 473 G>V No EVA
rs3388947450 474 S>R No EVA
rs3388963616 475 S>R No EVA
rs219249533 519 D>E No EVA
rs3388947419 521 S>G No EVA
rs3388969895 531 C>R No EVA
rs3388958748 550 F>S No EVA
rs3388963596 556 E>* No EVA
rs3388961487 597 E>G No EVA
rs864306842 615 M>K No EVA
rs3388965293 631 Q>* No EVA
rs3413126518 631 Q>H No EVA
rs3388966534 637 K>N No EVA
rs3388953381 644 S>F No EVA
rs3388957916 650 M>K No EVA
rs226754214 665 D>E No EVA
rs3388953346 674 F>I No EVA
rs3388919265 691 V>A No EVA
rs3388966561 698 A>T No EVA
rs6305405 710 F>L No EVA
rs261468742 719 Q>* No EVA
rs3388966196 724 D>N No EVA

No associated diseases with Q711T7

2 regional properties for Q711T7

Type Name Position InterPro Accession
domain Carbon-nitrogen hydrolase 5 - 282 IPR003010
domain NAD/GMP synthase 339 - 598 IPR022310

Functions

Description
EC Number 6.3.5.1 Carbon--nitrogen ligases with glutamine as amido-N-donor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
glutaminase activity Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3.
NAD+ synthase (glutamine-hydrolyzing) activity Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate.
NAD+ synthase activity Catalysis of the reaction: ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+.

2 GO annotations of biological process

Name Definition
'de novo' NAD biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of tryptophan or aspartate from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH.
NAD biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9VYA0 Nadsyn Glutamine-dependent NAD(+) synthetase Drosophila melanogaster (Fruit fly) PR
Q812E8 Nadsyn1 Glutamine-dependent NAD(+) synthetase Rattus norvegicus (Rat) PR
Q0D8D4 Os07g0167100 Glutamine-dependent NAD(+) synthetase Oryza sativa subsp japonica (Rice) PR
Q9C723 At1g55090 Glutamine-dependent NAD(+) synthetase Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MGRKVTVATC ALNQWALDFE GNFQRILKSI QIAKGKGARY RLGPELEICG YGCWDHYHES
70 80 90 100 110 120
DTLLHSLQVL AALLDSPVTQ DIICDVGMPI MHRNVRYNCR VIFLNRKILL IRPKMALANE
130 140 150 160 170 180
GNYRELRWFT PWTRSRQTEE YVLPRMLQDL TKQKTVPFGD VVLATQDTCV GSEICEELWT
190 200 210 220 230 240
PRSPHIDMGL DGVEIITNAS GSHHVLRKAH TRVDLVTMAT SKNGGIYLLA NQKGCDGDRL
250 260 270 280 290 300
YYDGCAMIAM NGSIFAQGTQ FSLDDVEVLT ATLDLEDVRS YKAEISSRNL EATRVSPYPR
310 320 330 340 350 360
VTVDFALSVS EDLLEPVSEP MEWTYHRPEE EISLGPACWL WDFLRRSKQA GFFLPLSGGV
370 380 390 400 410 420
DSAASACIVY SMCCLVCDAV KSGNQQVLTD VQNLVDESSY TPQDPRELCG RLLTTCYMAS
430 440 450 460 470 480
ENSSQETHSR ATKLAQLIGS YHINLSIDTA VKAVLGIFSL MTGKLPRFSA HGGSSRENLA
490 500 510 520 530 540
LQNVQARIRM VLAYLFAQLS LWSRGARGSL LVLGSANVDE SLLGYLTKYD CSSADINPIG
550 560 570 580 590 600
GISKTDLRAF VQFCAERFQL PVLQTILSAP ATAELEPLAD GQVSQMDEED MGMTYAELSI
610 620 630 640 650 660
FGRLRKVAKA GPYSMFCKLL NMWRDSYTPT QVAEKVKLFF SKYSMNRHKM TTLTPAYHAE
670 680 690 700 710 720
NYSPDDNRFD LRPFLYNTRW PWQFLCIDNQ VLQLERKASQ TREEQVLEHF KEPSPIWKQL
LPKDP