Q9ULC4

PR
Gene name
MCTS1 (MCT1)
Protein name
Malignant T-cell-amplified sequence 1
Names
MCT-1, Multiple copies T-cell malignancies
Species
Homo sapiens (Human)
KEGG Pathway
hsa:28985
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-55 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for Q9ULC4

Entry ID Method Resolution Chain Position Source
3R90 X-ray 170 A A/B/C/D/E/F/G/H/I/J/K/L 1-181 PDB
5ONS X-ray 214 A A 1-181 PDB
5VYC X-ray 600 A k1/k2/k3/k4/k5/k6 1-181 PDB
6MS4 X-ray 200 A A 1-181 PDB
AF-Q9ULC4-F1 Predicted AlphaFoldDB

46 variants for Q9ULC4

Variant ID(s) Position Change Description Diseaes Association Provenance
CA10505839
rs758913648
 6 D>G No ClinGen
ExAC
TCGA novel 16 Q>V Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 23 K>T Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs143806871
CA10505842
 24 G>C No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
CA334137807
rs1004370530
 29 L>F No ClinGen
Ensembl
CA414199630
rs1249333621
 30 I>M No ClinGen
TOPMed
gnomAD
TCGA novel 31 E>D Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA10505846
rs775619303
 37 E>D No ClinGen
ExAC
TOPMed
gnomAD
CA414199820
rs1387790259
 39 W>R No ClinGen
gnomAD
CA644084093
rs1168862489
 43 I>Y No ClinGen
gnomAD
rs1322791458
CA414200033
 46 K>N Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
CA10505848
rs767448676
 46 K>R No ClinGen
ExAC
gnomAD
TCGA novel 49 P>S Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA334137862
rs886159046
 52 I>T No ClinGen
TOPMed
CA414200194
rs1441730371
 53 V>I No ClinGen
gnomAD
TCGA novel 55 C>= Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs773027930
CA10505849
 55 C>S No ClinGen
ExAC
TOPMed
gnomAD
TCGA novel 56 H>Y Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 62 L>R Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
COSM3357377
COSM3357376
rs368656330
CA334138078
 70 F>L haematopoietic_and_lymphoid_tissue [Cosmic] No ClinGen
cosmic curated
Ensembl
TCGA novel 70 F>Y Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 72 R>* Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA10505857
rs148197434
RCV000886057
 72 R>K No ClinGen
ClinVar
1000Genomes
ESP
ExAC
TOPMed
dbSNP
gnomAD
rs867406427
CA334138091
 76 G>E No ClinGen
Ensembl
CA414200820
rs1602607423
 77 P>T No ClinGen
Ensembl
TCGA novel 79 Y>I Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA10505859
rs186248794
 83 R>K No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
TCGA novel 89 P>H Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs768630921
CA10505869
 102 I>V No ClinGen
ExAC
gnomAD
VAR_045632
rs2233110
CA334139064
 106 L>H No ClinGen
UniProt
Ensembl
dbSNP
rs1205270767
CA414201595
 107 S>G No ClinGen
gnomAD
CA414201803
rs1285912199
 119 P>S No ClinGen
gnomAD
rs1171220802
CA414201917
 126 A>V No ClinGen
TOPMed
rs376777652
CA10505880
 133 A>V No ClinGen
ESP
ExAC
CA10505882
rs757817901
 137 E>K No ClinGen
ExAC
gnomAD
TCGA novel 138 G>R Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1569405242
CA414202982
 140 Q>P No ClinGen
Ensembl
CA10505883
rs781770521
 142 A>T No ClinGen
ExAC
gnomAD
rs1602609602
CA414203136
 147 V>D No ClinGen
Ensembl
rs867867687
CA334140464
 152 A>E No ClinGen
Ensembl
CA414203295
rs750777684
 154 D>H No ClinGen
ExAC
gnomAD
CA10505884
rs750777684
 154 D>N No ClinGen
ExAC
gnomAD
TCGA novel 157 K>N Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA10505897
rs759305493
 158 V>I No ClinGen
ExAC
TOPMed
gnomAD
TCGA novel 168 H>N Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA414203849
rs1291904561
 172 D>N No ClinGen
TOPMed

No associated diseases with Q9ULC4

3 regional properties for Q9ULC4

Type Name Position InterPro Accession
domain PUA domain 93 - 171 IPR002478
domain Uncharacterised domain CHP00451 63 - 172 IPR004521
domain Pre-PUA domain 5 - 89 IPR041366

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nuclear relocalization after DNA damage
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

6 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cellular response to DNA damage stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
formation of translation preinitiation complex The joining of the small ribosomal subunit, ternary complex, and mRNA.
IRES-dependent viral translational initiation Process by which viral mRNA translation is initiated, where a domain in the 5' untranslated region (UTR) of the viral mRNA called an internal ribosome entry site (IRES) binds the host 43S preinitiation complex, circumventing regular cap-dependent translation initiation.
positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation.
ribosome disassembly The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P89886 ORF3 Translation machinery-associated protein 20 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q2KIE4 MCTS1 Malignant T-cell-amplified sequence 1 Bos taurus (Bovine) PR
Q5ZI42 MCTS1 Malignant T-cell-amplified sequence 1 Gallus gallus (Chicken) PR
Q9W445 MCTS1 Malignant T-cell-amplified sequence 1 homolog Drosophila melanogaster (Fruit fly) PR
Q9CQ21 Mcts2 Malignant T-cell-amplified sequence 2 Mus musculus (Mouse) PR
Q9DB27 Mcts1 Malignant T-cell-amplified sequence 1 Mus musculus (Mouse) PR
Q4G009 Mcts1 Malignant T-cell-amplified sequence 1 Rattus norvegicus (Rat) PR
Q6DER1 mcts1 Malignant T-cell-amplified sequence 1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q7ZV34 mcts1 Malignant T-cell-amplified sequence 1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MFKKFDEKEN VSNCIQLKTS VIKGIKNQLI EQFPGIEPWL NQIMPKKDPV KIVRCHEHIE
70 80 90 100 110 120
ILTVNGELLF FRQREGPFYP TLRLLHKYPF ILPHQQVDKG AIKFVLSGAN IMCPGLTSPG
130 140 150 160 170 180
AKLYPAAVDT IVAIMAEGKQ HALCVGVMKM SAEDIEKVNK GIGIENIHYL NDGLWHMKTY
K