Q9DB27
Gene name |
Mcts1 |
Protein name |
Malignant T-cell-amplified sequence 1 |
Names |
MCT-1, Multiple copies T-cell malignancies 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:68995 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9DB27
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9DB27-F1 | Predicted | AlphaFoldDB |
11 variants for Q9DB27
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3409518280 | 14 | C>W | No | EVA | |
| rs3413067478 | 15 | I>M | No | EVA | |
| rs3409889142 | 18 | K>E | No | EVA | |
| rs3410506375 | 18 | K>N | No | EVA | |
| rs3409929088 | 31 | E>* | No | EVA | |
| rs3410136327 | 33 | F>S | No | EVA | |
| rs3410136318 | 34 | P>T | No | EVA | |
| rs3407817357 | 65 | N>I | No | EVA | |
| rs3389568769 | 131 | I>T | No | EVA | |
| rs3409170048 | 178 | K>Q | No | EVA | |
| rs3389523711 | 180 | Y>F | No | EVA |
No associated diseases with Q9DB27
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosolic small ribosomal subunit | The small subunit of a ribosome located in the cytosol. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| translation initiation factor activity | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| cellular response to DNA damage stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. |
| formation of translation preinitiation complex | The joining of the small ribosomal subunit, ternary complex, and mRNA. |
| IRES-dependent viral translational initiation | Process by which viral mRNA translation is initiated, where a domain in the 5' untranslated region (UTR) of the viral mRNA called an internal ribosome entry site (IRES) binds the host 43S preinitiation complex, circumventing regular cap-dependent translation initiation. |
| ribosome disassembly | The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P89886 | ORF3 | Translation machinery-associated protein 20 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q2KIE4 | MCTS1 | Malignant T-cell-amplified sequence 1 | Bos taurus (Bovine) | PR |
| Q5ZI42 | MCTS1 | Malignant T-cell-amplified sequence 1 | Gallus gallus (Chicken) | PR |
| Q9W445 | MCTS1 | Malignant T-cell-amplified sequence 1 homolog | Drosophila melanogaster (Fruit fly) | PR |
| Q9ULC4 | MCTS1 | Malignant T-cell-amplified sequence 1 | Homo sapiens (Human) | PR |
| Q9CQ21 | Mcts2 | Malignant T-cell-amplified sequence 2 | Mus musculus (Mouse) | PR |
| Q4G009 | Mcts1 | Malignant T-cell-amplified sequence 1 | Rattus norvegicus (Rat) | PR |
| Q6DER1 | mcts1 | Malignant T-cell-amplified sequence 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q7ZV34 | mcts1 | Malignant T-cell-amplified sequence 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MFKKFDEKEN | VSNCIQLKTS | VIKGIKNQLL | EQFPGIEPWL | NQIMPKKDPV | KIVRCHEHIE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ILTVNGELLF | FRQREGPFYP | TLRLLHKYPF | ILPHQQVDKG | AIKFVLSGAN | IMCPGLTSPG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AKLYPAAVDT | IVAIMAEGKQ | HALCVGVMKM | SAEDIEKVNK | GIGIENIHYL | NDGLWHMKTY |
| K |