P89886

PR
Gene name
ORF3
Protein name
Translation machinery-associated protein 20
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YER007C-A
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-58 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P89886

Entry ID Method Resolution Chain Position Source
AF-P89886-F1 Predicted AlphaFoldDB

2 variants for P89886

Variant ID(s) Position Change Description Diseaes Association Provenance
s05-166669 38 V>A No SGRP
s05-166300 161 K>R No SGRP

No associated diseases with P89886

3 regional properties for P89886

Type Name Position InterPro Accession
domain PUA domain 91 - 172 IPR002478
domain Uncharacterised domain CHP00451 61 - 173 IPR004521
domain Pre-PUA domain 7 - 87 IPR041366

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

1 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.

2 GO annotations of biological process

Name Definition
formation of translation preinitiation complex The joining of the small ribosomal subunit, ternary complex, and mRNA.
ribosome biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2KIE4 MCTS1 Malignant T-cell-amplified sequence 1 Bos taurus (Bovine) PR
Q5ZI42 MCTS1 Malignant T-cell-amplified sequence 1 Gallus gallus (Chicken) PR
Q9W445 MCTS1 Malignant T-cell-amplified sequence 1 homolog Drosophila melanogaster (Fruit fly) PR
Q9ULC4 MCTS1 Malignant T-cell-amplified sequence 1 Homo sapiens (Human) PR
Q9CQ21 Mcts2 Malignant T-cell-amplified sequence 2 Mus musculus (Mouse) PR
Q9DB27 Mcts1 Malignant T-cell-amplified sequence 1 Mus musculus (Mouse) PR
Q4G009 Mcts1 Malignant T-cell-amplified sequence 1 Rattus norvegicus (Rat) PR
Q6DER1 mcts1 Malignant T-cell-amplified sequence 1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q7ZV34 mcts1 Malignant T-cell-amplified sequence 1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MFKKFTREDV HSRSKVKSSI QRTLKAKLVK QYPKIEDVID ELIPKKSQIE LIKCEDKIQL
70 80 90 100 110 120
YSVDGEVLFF QKFDELIPSL KLVHKFPEAY PTVQVDRGAI KFVLSGANIM CPGLTSAGAD
130 140 150 160 170 180
LPPAPGYEKG TIVVINAENK ENALAIGELM MGTEEIKSVN KGHSIELIHH LGDPLWNFSV
E