Q2KIE4
Gene name |
MCTS1 |
Protein name |
Malignant T-cell-amplified sequence 1 |
Names |
MCT-1 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:508412 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q2KIE4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q2KIE4-F1 | Predicted | AlphaFoldDB |
21 variants for Q2KIE4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs441173630 | 3 | K>E | No | EVA | |
| rs475794470 | 29 | L>S | No | EVA | |
| rs458779445 | 32 | Q>P | No | EVA | |
| rs438788004 | 41 | N>H | No | EVA | |
| rs473347759 | 41 | N>K | No | EVA | |
| rs453300581 | 42 | Q>E | No | EVA | |
| rs436425317 | 42 | Q>H | No | EVA | |
| rs436908425 | 58 | H>N | No | EVA | |
| rs465052603 | 58 | H>Q | No | EVA | |
| rs445039869 | 60 | E>K | No | EVA | |
| rs479367299 | 61 | I>N | No | EVA | |
| rs449061133 | 62 | L>P | No | EVA | |
| rs480441222 | 64 | V>I | No | EVA | |
| rs463745072 | 65 | N>D | No | EVA | |
| rs458245090 | 70 | F>S | No | EVA | |
| rs441397491 | 84 | L>F | No | EVA | |
| rs471067154 | 91 | I>T | No | EVA | |
| rs433960600 | 95 | Q>E | No | EVA | |
| rs468678753 | 107 | S>R | No | EVA | |
| rs436996145 | 149 | K>M | No | EVA | |
| rs455560948 | 168 | H>R | No | EVA |
No associated diseases with Q2KIE4
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| translation initiation factor activity | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| cellular response to DNA damage stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. |
| formation of translation preinitiation complex | The joining of the small ribosomal subunit, ternary complex, and mRNA. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P89886 | ORF3 | Translation machinery-associated protein 20 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q5ZI42 | MCTS1 | Malignant T-cell-amplified sequence 1 | Gallus gallus (Chicken) | PR |
| Q9W445 | MCTS1 | Malignant T-cell-amplified sequence 1 homolog | Drosophila melanogaster (Fruit fly) | PR |
| Q9ULC4 | MCTS1 | Malignant T-cell-amplified sequence 1 | Homo sapiens (Human) | PR |
| Q9CQ21 | Mcts2 | Malignant T-cell-amplified sequence 2 | Mus musculus (Mouse) | PR |
| Q9DB27 | Mcts1 | Malignant T-cell-amplified sequence 1 | Mus musculus (Mouse) | PR |
| Q4G009 | Mcts1 | Malignant T-cell-amplified sequence 1 | Rattus norvegicus (Rat) | PR |
| Q6DER1 | mcts1 | Malignant T-cell-amplified sequence 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q7ZV34 | mcts1 | Malignant T-cell-amplified sequence 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MFKKFDEKEN | VSNCIQLKTS | VIKGIKNQLI | EQFPGIEPWL | NQIMPKKDPV | KIVRCHEHIE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ILTVNGELLF | FRQREGPFYP | TLRLLHKYPF | ILPHQQVDKG | AIKFVLSGAN | IMCPGLTSPG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AKLYPAAVDT | IVAIMAEGKQ | HALCVGVMKM | SAEDIEKVNK | GIGIENIHYL | NDGLWHMKTY |
| K |