AiPD: Autoinhibited Protein Database

Q9UBJ2

Gene name	ABCD2
Protein name	ATP-binding cassette sub-family D member 2
Names	Adrenoleukodystrophy-like 1, Adrenoleukodystrophy-related protein, hALDR
Species	Homo sapiens (Human)
KEGG Pathway	hsa:225
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

19-105 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

19-105 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9UBJ2

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9UBJ2-F1	Predicted				AlphaFoldDB

489 variants for Q9UBJ2

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs747881435 CA6511824	2	T>I		No	ClinGen ExAC gnomAD
rs773860547 CA6511823	3	H>Y		No	ClinGen ExAC gnomAD
TCGA novel	4	M>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6511822 rs768562728	4	M>L		No	ClinGen ExAC gnomAD
rs1566597431 CA384401528	6	N>K		No	ClinGen Ensembl
rs779933199 CA6511820	7	A>E		No	ClinGen ExAC
rs749041653 CA6511821	7	A>S		No	ClinGen ExAC
CA384401495 rs1287307957	8	A>V		No	ClinGen gnomAD
CA6511818 rs117275340	9	A>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6511815 rs745758365	11	R>Q		No	ClinGen ExAC gnomAD
rs1160480470 CA384401402	13	K>T		No	ClinGen gnomAD
rs1393123777 CA384401302	17	S>P		No	ClinGen gnomAD
rs199684530 CA6511811	18	S>R		No	ClinGen 1000Genomes ExAC gnomAD
CA384401229 rs1472517602	20	A>V		No	ClinGen TOPMed
TCGA novel	22	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1184378818 CA384401186	23	A>T		No	ClinGen gnomAD
TCGA novel	24	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1485319494 CA384401171	24	A>P		No	ClinGen TOPMed gnomAD
rs1485319494 CA384401172	24	A>T		No	ClinGen TOPMed gnomAD
rs756904045 CA6511810	25	C>G		No	ClinGen ExAC TOPMed gnomAD
CA235298185 rs756904045	25	C>S		No	ClinGen ExAC TOPMed gnomAD
rs1015418351 CA235298175	25	C>W		No	ClinGen TOPMed
rs1388070431 CA384401142	26	L>M		No	ClinGen TOPMed
CA235298149 rs947503774	29	A>V		No	ClinGen TOPMed
CA384401066 rs1294969865	32	A>T		No	ClinGen TOPMed
CA384401024 rs1592003750	35	T>P		No	ClinGen Ensembl
CA384401012 rs914521439	36	L>F		No	ClinGen TOPMed gnomAD
rs914521439 CA235298138	36	L>V		No	ClinGen TOPMed gnomAD
CA384400993 rs1382031972	37	Y>C		No	ClinGen TOPMed gnomAD
CA384400974 rs1362852198	38	P>L	Variant assessed as Somatic; 9.501e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1374987773 CA384400950	40	I>T		No	ClinGen gnomAD
CA384400956 rs1413009013	40	I>V		No	ClinGen gnomAD
CA6511806 rs142507537	42	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs1379334679 CA384400875	45	K>R		No	ClinGen gnomAD
CA235298109 rs148402840	47	S>C		No	ClinGen ESP TOPMed
rs547432731 CA235298103	49	H>Q		No	ClinGen gnomAD
CA384400809 rs547432731	49	H>Q		No	ClinGen gnomAD
CA6511803 rs768203523	50	G>R		No	ClinGen ExAC TOPMed gnomAD
CA6511802 rs768203523	50	G>R		No	ClinGen ExAC TOPMed gnomAD
CA384400803 rs768203523	50	G>W		No	ClinGen ExAC TOPMed gnomAD
CA6511800 rs775454584	51	K>T		No	ClinGen ExAC gnomAD
rs1258758968 CA384400770	53	K>N		No	ClinGen TOPMed
CA384400764 rs1200564768	54	A>E		No	ClinGen gnomAD
TCGA novel	54	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	54	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6511799 rs574474772	55	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs745852510 CA6511798	56	A>G		No	ClinGen ExAC gnomAD
rs1566597004 CA384400747	56	A>P		No	ClinGen Ensembl
CA384400714 rs1308517280	58	P>R		No	ClinGen gnomAD
CA384400719 rs1227065556	58	P>S		No	ClinGen gnomAD
rs772265422 CA6511796	59	A>T		No	ClinGen ExAC gnomAD
rs748185349 CA6511795	61	E>G		No	ClinGen ExAC gnomAD
rs778993146 CA6511794	62	N>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs77536431 CA6511793	63	T>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA384400639 rs1404197332	64	E>K		No	ClinGen gnomAD
CA6511790 rs780438298	66	L>P		No	ClinGen ExAC TOPMed gnomAD
CA384400603 rs754020573	66	L>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	68	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA384400558 rs1473996904	69	T>I		No	ClinGen gnomAD
rs1592003614 CA384400547	70	E>K		No	ClinGen Ensembl
CA6511786 rs762323562	71	T>A		No	ClinGen ExAC gnomAD
rs751049564 CA6511785	71	T>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1195787886 CA384400467	75	K>N		No	ClinGen gnomAD
TCGA novel	78	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA384400411 rs1212246542	79	G>E		No	ClinGen gnomAD
CA6511784 rs763616857	80	V>M		No	ClinGen ExAC TOPMed gnomAD
rs374989744 CA235298001	81	N>H		No	ClinGen ESP
CA384400332 rs1275495418	83	D>G		No	ClinGen TOPMed
CA384400264 rs1334113735	86	K>I		No	ClinGen gnomAD
CA6511783 rs762731548	87	Q>E		No	ClinGen ExAC TOPMed gnomAD
COSM938967 rs1390785264 CA384400243	87	Q>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1333059727 CA384400207	89	L>P		No	ClinGen gnomAD
rs139904825 CA235297988	90	E>K		No	ClinGen ESP TOPMed
CA235297983 rs200311534	91	L>P		No	ClinGen 1000Genomes
rs1023375791 CA235297965	92	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs962488608 CA235297970	92	R>W		No	ClinGen TOPMed gnomAD
CA384400085 rs1409666453	96	F>L		No	ClinGen Ensembl
rs1188766536 CA384400077	96	F>S		No	ClinGen TOPMed
RCV000676171 CA6511780 rs373396030	98	K>E		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
CA384400001 rs1393194038	99	L>F		No	ClinGen gnomAD
CA6511779 rs776421572	100	V>E		No	ClinGen ExAC gnomAD
CA6511778 rs770791451	102	T>A		No	ClinGen ExAC TOPMed gnomAD
rs746919265 CA6511777	103	E>K		No	ClinGen ExAC gnomAD
TCGA novel	107	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778894311 CA6511776	107	L>I		No	ClinGen ExAC gnomAD
rs1177526076 CA384399830	108	C>S		No	ClinGen TOPMed
CA235297920 rs960384952	111	S>T		No	ClinGen Ensembl
rs145994192 CA235297912	112	V>L		No	ClinGen ESP TOPMed gnomAD
CA384399637 rs1300934205	117	R>G		No	ClinGen TOPMed
rs1290860282 CA384399601	118	T>I		No	ClinGen TOPMed gnomAD
CA384399615 rs1468325635	118	T>P		No	ClinGen gnomAD
rs1290860282 CA384399605	118	T>S		No	ClinGen TOPMed gnomAD
rs756258266 CA6511772	120	L>F		No	ClinGen ExAC gnomAD
TCGA novel	120	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs142601254 CA6511770	122	I>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs746240904 CA6511771	122	I>V		No	ClinGen ExAC gnomAD
rs201591906 CA6511769	123	Y>C		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	123	Y>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6511767 rs138119938	126	G>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6511768 rs138119938	126	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA235297856 rs1028313449	129	G>R		No	ClinGen TOPMed
CA384399267 rs974040132	131	I>F		No	ClinGen TOPMed
CA235297838 rs974040132	131	I>L		No	ClinGen TOPMed
TCGA novel	131	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1592003379 CA384399229	133	K>Q		No	ClinGen Ensembl
CA6511765 rs752466432	134	S>I		No	ClinGen ExAC TOPMed gnomAD
CA384399174 rs752466432	134	S>N		No	ClinGen ExAC TOPMed gnomAD
CA384399143 rs1388193328	136	V>M		No	ClinGen TOPMed gnomAD
rs1388887587 CA384399134	137	E>K		No	ClinGen gnomAD
CA384399103 rs1191109254	138	K>E		No	ClinGen gnomAD
rs764987756 CA6511764	140	P>T		No	ClinGen ExAC gnomAD
rs766162060 CA384399040	141	R>L		No	ClinGen ExAC TOPMed gnomAD
CA6511761 COSM693257 rs766162060	141	R>Q	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA6511762 rs776317283	141	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs760573269 CA6511760	142	T>A		No	ClinGen ExAC TOPMed gnomAD
CA384399016 rs1592003330	142	T>I		No	ClinGen Ensembl
CA235297769 rs185807859	143	F>L		No	ClinGen 1000Genomes
CA6511759 rs549683860	145	I>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1247693957 CA384398903	147	L>I		No	ClinGen gnomAD
rs1414028696 CA384398872	148	I>M		No	ClinGen TOPMed
CA384398867 rs1457599906	149	K>E		No	ClinGen TOPMed
CA6511758 rs749370948	149	K>N		No	ClinGen ExAC gnomAD
CA6511757 rs749370948	149	K>N		No	ClinGen ExAC gnomAD
rs150810572 CA6511756	152	M>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed
CA235297739 rs752263937	156	P>H		No	ClinGen Ensembl
TCGA novel	159	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1288059904 CA384398628	160	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	162	S>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs531465164 CA6511753	164	I>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1343993164 CA384398525	165	R>S		No	ClinGen gnomAD
CA6511752 rs757618278	166	Y>N		No	ClinGen ExAC gnomAD
CA235297701 rs1011196983	170	K>E		No	ClinGen TOPMed gnomAD
CA6511750 rs778340940	172	A>G		No	ClinGen ExAC gnomAD
CA6511751 rs747525311	172	A>T		No	ClinGen ExAC gnomAD
rs758909335 CA6511749	174	A>V		No	ClinGen ExAC
TCGA novel	176	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6511748 rs752270059	178	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA384398329 rs764791765	178	R>H		No	ClinGen ExAC gnomAD
rs764791765 CA6511747	178	R>L		No	ClinGen ExAC gnomAD
rs1434596616 CA384398318	179	L>P		No	ClinGen gnomAD
CA384398283 rs1174615337	181	D>A		No	ClinGen gnomAD
CA6511746 rs35217341	182	H>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1219205420 CA384398262	183	A>T		No	ClinGen TOPMed
rs1039832381 CA235297641	183	A>V		No	ClinGen TOPMed
CA6511744 rs766139244	185	E>D		No	ClinGen ExAC gnomAD
CA384398226 rs1331758067	185	E>K		No	ClinGen TOPMed
CA6511742 rs148301688	186	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA6511743 rs148301688	186	T>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA6511741 rs372256799	189	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA384398154 rs1255545355	191	Q>H		No	ClinGen gnomAD
CA384398151 rs1223273601	192	T>A		No	ClinGen TOPMed
rs761685898 CA6511740	194	Y>*		No	ClinGen ExAC gnomAD
rs746123650 CA6511737	196	V>L		No	ClinGen ExAC gnomAD
CA6511738 rs746123650	196	V>M		No	ClinGen ExAC gnomAD
CA6511736 rs774743963	197	I>F		No	ClinGen ExAC gnomAD
CA6511734 rs747405988	198	N>S		No	ClinGen ExAC TOPMed gnomAD
CA384398100 rs1592003182	198	N>Y		No	ClinGen Ensembl
CA6511733 rs778226831	199	M>T		No	ClinGen ExAC gnomAD
CA6511732 rs772728599	201	G>A		No	ClinGen ExAC gnomAD
TCGA novel	201	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs748629476 CA6511731	204	A>T		No	ClinGen ExAC gnomAD
rs368375856 CA6511730	204	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs902948251 CA235297542	205	N>K		No	ClinGen TOPMed
rs1041465961 CA235297535	206	P>T		No	ClinGen TOPMed
TCGA novel	207	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs201411952 CA235297523 COSM1181370	211	T>M	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed
CA384397800 rs1301313172	215	M>L		No	ClinGen TOPMed
CA235297516 rs200378111	215	M>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6511725 rs200378111	215	M>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1410969094 CA384397781	216	M>V		No	ClinGen TOPMed
rs1478246275 CA384397728	218	S>C		No	ClinGen Ensembl
CA235297506 rs932955719	219	Q>R		No	ClinGen TOPMed
TCGA novel	220	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1355541295 CA384397652	223	H>R		No	ClinGen gnomAD
CA384397640 rs1473170831	224	L>F		No	ClinGen gnomAD
rs767255509 CA6511723	228	L>M		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	229	T>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751475679 CA6511721	236	M>V		No	ClinGen ExAC gnomAD
TCGA novel	238	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1199057969 CA384397346	239	S>T		No	ClinGen gnomAD
CA384397122 rs1227238445	248	S>F		No	ClinGen gnomAD
CA6511718 rs776509690	250	G>E		No	ClinGen ExAC gnomAD
rs1286445180 CA384397060	251	A>E		No	ClinGen gnomAD
CA384397053 rs1320670707	252	S>R		No	ClinGen TOPMed
rs376662929 CA6511717	253	P>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA6511715 rs201891055	254	I>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA6511714 rs201891055	254	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA6511716 rs760760553	254	I>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	256	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	256	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	259	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1306975066 CA384396855	261	G>E		No	ClinGen gnomAD
rs768974468 CA6511711	273	A>T		No	ClinGen ExAC TOPMed gnomAD
rs963234559 CA235297363	280	K>E		No	ClinGen TOPMed gnomAD
rs748840539 CA235297329	281	L>M		No	ClinGen ExAC TOPMed gnomAD
CA384395637 rs1170858712	283	A>S		No	ClinGen TOPMed gnomAD
CA384395643 rs1170858712	283	A>T		No	ClinGen TOPMed gnomAD
CA235297325 rs558419291	285	E>G		No	ClinGen Ensembl
rs755818457 CA6511708	286	A>S		No	ClinGen ExAC gnomAD
TCGA novel	286	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA235297292 rs781012632	287	H>Q		No	ClinGen ExAC TOPMed
CA384395502 rs1270880411	288	R>T		No	ClinGen gnomAD
CA6511705 rs368939667	289	K>*		No	ClinGen ESP ExAC gnomAD
rs1431004420 CA384395478	289	K>R		No	ClinGen TOPMed
rs753975268 CA6511701	293	R>L		No	ClinGen ExAC TOPMed gnomAD
CA6511702 rs753975268	293	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs373640731 CA6511703	293	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA384395375 rs1285092501	294	Y>H		No	ClinGen TOPMed
TCGA novel	294	Y>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs766329449 CA6511700	296	H>L		No	ClinGen ExAC gnomAD
TCGA novel	296	H>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1449446888 CA384395324	296	H>Y		No	ClinGen gnomAD
CA6511699 rs773549369	297	S>*		No	ClinGen ExAC gnomAD
CA6511698 rs773549369	297	S>L		No	ClinGen ExAC gnomAD
rs1566595333 CA384395228	300	I>T		No	ClinGen Ensembl
TCGA novel	307	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6511693 COSM3931623 rs749715188	310	R>K	urinary_tract [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA384394972 rs1379602584	311	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA384394964 rs1159252631	311	G>V		No	ClinGen gnomAD
TCGA novel	313	K>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA384394561 rs1450968024	314	V>G		No	ClinGen gnomAD
rs1363562031 CA384394518	316	M>T		No	ClinGen TOPMed
CA384394459 rs1426811947	319	L>F		No	ClinGen TOPMed gnomAD
CA235296014 rs548358484	323	Y>C		No	ClinGen 1000Genomes
rs1191144099 CA384394363	324	K>R		No	ClinGen gnomAD
CA384394353 rs1487656008	325	A>P		No	ClinGen gnomAD
CA6511672 rs775846982	331	N>K		No	ClinGen ExAC gnomAD
rs933140507 CA235296003	333	I>L		No	ClinGen TOPMed gnomAD
CA384394146 rs1336644503	333	I>T		No	ClinGen TOPMed
CA384394071 rs1255939120	337	R>C		No	ClinGen gnomAD
rs776062597 CA6511669	337	R>H		No	ClinGen ExAC gnomAD
CA384394054 rs1314380612	338	L>F		No	ClinGen gnomAD
rs1341388131 CA384394029	339	W>C		No	ClinGen gnomAD
CA6511667 rs746625113	339	W>L		No	ClinGen ExAC gnomAD
CA6511668 rs770594701	339	W>R		No	ClinGen ExAC TOPMed gnomAD
CA384394050 rs770594701	339	W>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	340	Y>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1280129489 CA384393996	341	I>F		No	ClinGen gnomAD
CA384393973 rs1413018230	342	M>T		No	ClinGen gnomAD
rs1248219239 CA384393940	343	I>T		No	ClinGen Ensembl
CA384393903 rs1399904027	345	Q>*		No	ClinGen gnomAD
rs374034238 CA6511664	348	M>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1007040024 CA235295928	350	Y>*		No	ClinGen TOPMed
CA235295921 rs758760543	354	S>I		No	ClinGen gnomAD
rs758760543 CA384393713	354	S>N		No	ClinGen gnomAD
TCGA novel	365	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	372	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6511662 rs754898936	373	G>S		No	ClinGen ExAC gnomAD
CA384393349 rs1201330730	373	G>V		No	ClinGen Ensembl
rs1320531273 CA384391966	374	E>G		No	ClinGen TOPMed
CA6511635 rs529162529	376	G>S		No	ClinGen ExAC gnomAD
CA384391929 rs1477547972	377	Q>*		No	ClinGen gnomAD
rs966254461 CA235290152	380	V>A		No	ClinGen TOPMed
CA6511634 rs751875238	380	V>I		No	ClinGen ExAC TOPMed gnomAD
CA235290153 rs751875238	380	V>L		No	ClinGen ExAC TOPMed gnomAD
CA6511633 rs376722302	381	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA384391844 rs1247117882	383	S>N		No	ClinGen gnomAD
rs373870416 CA6511632	385	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1323359345 CA384391829	385	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA6511631 rs753027081	386	T>I		No	ClinGen ExAC gnomAD
CA384391810 rs1377421022	387	E>K		No	ClinGen gnomAD
CA384391779 rs1384669200	389	F>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
COSM1181371 CA384391722 rs1163266610	394	N>H	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
TCGA novel	395	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA384391633 rs1270361413	403	I>V		No	ClinGen TOPMed
CA235290095 rs950914581	408	S>F		No	ClinGen Ensembl
CA384391595 rs1197225194	408	S>P		No	ClinGen gnomAD
TCGA novel	408	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA384391580 rs1591996478	410	Y>F		No	ClinGen Ensembl
rs1451209889 CA384391584	410	Y>H		No	ClinGen gnomAD
COSM938962 rs1591996467 CA384391567	412	E>*	endometrium [Cosmic]	No	ClinGen cosmic curated Ensembl
CA384391538 rs1286278276	415	E>K		No	ClinGen gnomAD
CA384391502 rs1367391769	420	T>A		No	ClinGen gnomAD
CA384391496 rs1344121468	421	A>T		No	ClinGen gnomAD
rs982860718 CA235288606	422	R>*		No	ClinGen TOPMed
rs1331595617 CA384391490	422	R>Q		No	ClinGen TOPMed
TCGA novel	425	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA384391455 rs1389208558	427	F>L		No	ClinGen TOPMed
CA235288597 rs775950642	433	V>E		No	ClinGen Ensembl
rs766881094 CA6511606	434	K>E		No	ClinGen ExAC gnomAD
CA235288573 rs916895058	438	Y>C		No	ClinGen TOPMed
TCGA novel	440	R>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	442	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs202150785 CA6511604	443	V>I		No	ClinGen ExAC TOPMed gnomAD
CA6511603 rs373930149	446	E>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs1319716387 CA384391317	446	E>D		No	ClinGen TOPMed
rs761417112 CA6511602	447	S>F		No	ClinGen ExAC gnomAD
rs1174704545 CA384391301	449	S>C		No	ClinGen TOPMed gnomAD
rs1174704545 CA384391302	449	S>G		No	ClinGen TOPMed gnomAD
CA384391300 rs1258957727	449	S>N		No	ClinGen TOPMed
rs764045904 CA6511600	450	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs762845047 CA6511599	451	S>R		No	ClinGen ExAC TOPMed gnomAD
rs775364971 CA6511598	453	N>H		No	ClinGen ExAC gnomAD
CA6511597 rs769873518	454	G>E		No	ClinGen ExAC TOPMed gnomAD
rs1243770666 CA384391243	457	V>A		No	ClinGen TOPMed gnomAD
rs1467309244 CA384391239	458	E>*		No	ClinGen Ensembl
rs145840107 CA6511593	464	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA384391153 rs1171782306	466	A>T		No	ClinGen TOPMed
CA384389867 rs1160809304	470	K>T		No	ClinGen TOPMed
CA6511573 rs768893354	472	I>M		No	ClinGen ExAC gnomAD
CA384389838 rs1566580469	474	V>A		No	ClinGen Ensembl
rs780442111 CA6511572	476	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs1317851870 CA384389828	476	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA6511570 rs192072180	477	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA384389815 rs1316617744	478	I>V		No	ClinGen TOPMed
CA384389788 rs1332268684	481	E>D		No	ClinGen gnomAD
TCGA novel	483	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1186144855 CA384389762	485	I>T		No	ClinGen gnomAD
CA6511568 rs368116807	487	T>I		No	ClinGen ESP ExAC gnomAD
CA6511567 rs757646271	488	P>L		No	ClinGen ExAC gnomAD
CA6511565 rs777378044	489	A>E		No	ClinGen ExAC TOPMed gnomAD
CA384389739 rs777378044	489	A>G		No	ClinGen ExAC TOPMed gnomAD
rs751137599 CA6511566	489	A>T		No	ClinGen ExAC gnomAD
rs758097606	490	G>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs758165290 CA6511564	490	G>R		No	ClinGen ExAC gnomAD
rs752376418 CA6511562	491	E>D		No	ClinGen ExAC gnomAD
rs1179062504 CA384389733	491	E>K		No	ClinGen TOPMed gnomAD
rs1179062504 CA384389732	491	E>Q		No	ClinGen TOPMed gnomAD
CA6511560 rs562234415	493	V>E		No	ClinGen 1000Genomes ExAC gnomAD
rs753513456 CA6511559	494	A>T		No	ClinGen ExAC gnomAD
CA384389704 rs1209069848	496	R>G		No	ClinGen TOPMed gnomAD
rs766356712 CA6511558	496	R>K		No	ClinGen ExAC TOPMed gnomAD
rs955662896 CA235300992	496	R>S		No	ClinGen gnomAD
CA384389657 rs1229410282	501	V>I		No	ClinGen TOPMed
TCGA novel	502	E>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	505	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6511540 rs766051640	506	H>Y		No	ClinGen ExAC gnomAD
rs1207708965 CA384389608	508	L>V		No	ClinGen TOPMed
CA384389594 rs1276316538	510	T>A		No	ClinGen gnomAD
CA384389590 rs1436850373	510	T>I		No	ClinGen TOPMed
CA384389593 rs1276316538	510	T>S		No	ClinGen gnomAD
rs763022591 CA6511536	512	P>L		No	ClinGen ExAC gnomAD
rs1357573101 CA384389561	515	C>Y		No	ClinGen gnomAD
CA6511535 rs775372659	516	G>V		No	ClinGen ExAC gnomAD
CA6511534 rs770074713	518	S>N		No	ClinGen ExAC gnomAD
rs1369703833 CA384389532	519	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA6511533 rs759637252	526	G>E		No	ClinGen ExAC gnomAD
TCGA novel	528	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1162874692 CA384389454	531	Y>C		No	ClinGen TOPMed
rs771401382 CA6511531	531	Y>N		No	ClinGen ExAC gnomAD
TCGA novel	533	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1252519892 CA384389435	534	V>I		No	ClinGen Ensembl
CA6511530 rs747576839	536	Y>C		No	ClinGen ExAC gnomAD
rs778421394 CA6511529	537	K>E		No	ClinGen ExAC gnomAD
CA235299820 rs923925749	538	P>S		No	ClinGen gnomAD
CA384389410 rs923925749	538	P>T		No	ClinGen gnomAD
rs1435045170 CA384389402	539	P>L		No	ClinGen gnomAD
CA235299813 rs935077571	539	P>S		No	ClinGen TOPMed
rs867795575 CA235299807	541	Q>P		No	ClinGen Ensembl
CA384389381 rs1482577178	542	H>Q		No	ClinGen gnomAD
CA384389375 rs1389295130	543	M>T		No	ClinGen gnomAD
rs1255732210 CA384389378	543	M>V		No	ClinGen gnomAD
rs1211275520 CA384389349	546	I>L		No	ClinGen gnomAD
rs1186781118 CA384386107	550	P>L		No	ClinGen TOPMed
CA384386092 rs1242705337	551	Y>C		No	ClinGen gnomAD
CA384386065 rs1319793084	552	M>I		No	ClinGen gnomAD
CA6511511 rs773655555	556	S>R		No	ClinGen ExAC TOPMed gnomAD
CA6511510 rs772732463	558	R>Q		No	ClinGen ExAC gnomAD
CA384385987 rs1328840526	558	R>W		No	ClinGen gnomAD
CA384385955 rs1389158925 COSM693261	560	Q>E	lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA6511506 rs749032652	563	Y>H		No	ClinGen ExAC gnomAD
CA384385850 rs1164819164	564	P>R		No	ClinGen gnomAD
rs900263230 CA235294315	566	S>A		No	ClinGen Ensembl
CA6511503 rs745683523	569	D>N		No	ClinGen ExAC gnomAD
CA384385756 rs1252945005	570	M>V		No	ClinGen gnomAD
CA384385740 rs1208123397	571	H>N		No	ClinGen gnomAD
CA384385732 rs1488233579	571	H>R		No	ClinGen gnomAD
rs780922654 CA6511502	572	D>G		No	ClinGen ExAC gnomAD
rs562792577 CA235294298	574	G>C		No	ClinGen ExAC TOPMed gnomAD
CA6511500 rs751429438	574	G>D		No	ClinGen ExAC gnomAD
CA6511501 rs562792577	574	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1229686213 CA384385667	576	T>A		No	ClinGen TOPMed
CA384385648 rs1306727761	577	D>E		No	ClinGen gnomAD
CA235294292 rs944353644	578	Q>H		No	ClinGen TOPMed gnomAD
CA6511499 rs765416303	579	D>N		No	ClinGen ExAC gnomAD
rs200462514 CA6511498	582	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200462514 CA384385590	582	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6511497 rs151149571	582	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs766723246 CA6511496	583	I>F		No	ClinGen ExAC gnomAD
rs1483463400 CA384385568	584	L>V		No	ClinGen TOPMed
rs113825871 CA235294277	585	H>R		No	ClinGen Ensembl
CA384385539 rs1303256170	586	N>S		No	ClinGen gnomAD
rs1427064095 CA384385513	588	H>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs760934544 CA6511495	589	L>I		No	ClinGen ExAC TOPMed gnomAD
CA384385486 rs1158358187	590	Y>C		No	ClinGen TOPMed gnomAD
CA384385490 rs1253995120	590	Y>D		No	ClinGen TOPMed
rs1389041686 CA384385474	591	H>Y		No	ClinGen TOPMed
CA6511493 rs201982720	592	I>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA384385447 COSM1361334 rs1175140260	593	V>A	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed
CA6511492 rs762435874	593	V>I		No	ClinGen ExAC gnomAD
CA235294266 rs545886629	595	R>S		No	ClinGen Ensembl
rs1415592931 CA384385413	596	E>K		No	ClinGen TOPMed gnomAD
CA384385392 rs1269634027	597	G>A		No	ClinGen gnomAD
CA384385390 rs1269634027	597	G>E		No	ClinGen gnomAD
rs1011018570 CA235291922	599	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA384383357 rs1011018570	599	W>C		No	ClinGen gnomAD
rs900410178 CA235291919	600	D>Y		No	ClinGen Ensembl
rs1432044925 CA384383327	601	A>T		No	ClinGen gnomAD
CA6511463 COSM360774 rs770550941	601	A>V	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA235291915 rs181210390	602	V>L		No	ClinGen 1000Genomes TOPMed gnomAD
rs1407112185 CA384383284	603	M>I		No	ClinGen gnomAD
rs746795285 CA6511462	603	M>T		No	ClinGen ExAC gnomAD
CA6511460 rs771936315	604	D>E		No	ClinGen ExAC TOPMed gnomAD
CA6511461 rs777577531	604	D>N		No	ClinGen ExAC TOPMed
COSM1705393 CA6511459 rs748071217	605	W>*	skin [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs143197357 CA6511458	607	D>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs143197357 CA6511457	607	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6511454 rs757448382	609	L>Q		No	ClinGen ExAC gnomAD
rs1051092011 CA235291889	611	G>*		No	ClinGen Ensembl
rs566826425 CA6511452	617	M>I		No	ClinGen 1000Genomes ExAC gnomAD
CA384383091 rs1311759246	618	G>S		No	ClinGen TOPMed
rs1460757498 CA384383082	618	G>V		No	ClinGen gnomAD
CA6511451 rs374704804	619	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA384383060 rs1456184553	620	A>D		No	ClinGen gnomAD
rs764793532 CA6511450	621	R>H		No	ClinGen ExAC gnomAD
rs764793532 CA6511449	621	R>P		No	ClinGen ExAC gnomAD
rs1214648087 CA384383034	622	M>I		No	ClinGen gnomAD
rs1342073150 CA384383005	624	Y>F		No	ClinGen gnomAD
rs1340465804 CA384382995	625	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
TCGA novel	630	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6511426 rs760297393	631	L>F		No	ClinGen ExAC gnomAD
rs1194112931 CA384382636	633	D>G		No	ClinGen TOPMed
COSM1606048 rs772908531 CA6511425	634	E>*	liver [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA384382611 rs1366119402	635	C>S		No	ClinGen gnomAD
CA384382601 rs1165173028	636	T>A		No	ClinGen gnomAD
rs1292918816 CA384382590	637	S>G		No	ClinGen TOPMed gnomAD
rs774235902 CA6511422	640	S>G		No	ClinGen ExAC gnomAD
CA384382537 rs1470971597	641	I>T		No	ClinGen gnomAD
CA6511420 rs749204245 COSM236672	644	E>K	prostate [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs776622197 CA6511419	646	K>M		No	ClinGen ExAC gnomAD
CA384382490 rs1294665929	648	F>I		No	ClinGen gnomAD
CA384382485 rs1351187794	648	F>L		No	ClinGen gnomAD
CA384382488 rs1214895990	648	F>S		No	ClinGen gnomAD
CA384382489 rs1214895990	648	F>Y		No	ClinGen gnomAD
rs771028895 CA6511418	650	A>T		No	ClinGen ExAC gnomAD
rs1178510878 CA384382456	651	A>S		No	ClinGen TOPMed
CA6511416 rs778060875	655	G>A		No	ClinGen ExAC gnomAD
CA384382366 rs1405641865	657	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA6511414 rs748536241	660	S>T		No	ClinGen ExAC gnomAD
rs779210966 CA6511413	661	I>V		No	ClinGen ExAC TOPMed gnomAD
CA384382259 rs1159608221	663	H>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA6511412 rs190980733	665	P>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6511398 rs760822721	669	K>N		No	ClinGen ExAC gnomAD
rs773117878 CA6511397	673	H>D		No	ClinGen ExAC gnomAD
rs772313596 CA6511396	682	G>S		No	ClinGen ExAC
rs1428370330 CA384378891	683	W>C		No	ClinGen gnomAD
CA6511395 rs748340230	684	R>C		No	ClinGen ExAC TOPMed gnomAD
CA6511394 COSM431056 rs779301167	684	R>H	lung Variant assessed as Somatic; 0.0 impact. breast [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA384378851 rs1242737023	687	Q>K		No	ClinGen gnomAD
CA384378813 rs1266423060	690	T>A		No	ClinGen TOPMed
rs944259941 CA235279188	692	I>N		No	ClinGen TOPMed gnomAD
CA6511390 rs756525333	692	I>V		No	ClinGen ExAC gnomAD
CA6511389 rs749976817	693	R>C		No	ClinGen ExAC TOPMed gnomAD
CA6511388 rs377751649	693	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs377751649 CA384378780	693	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1230437921 CA384378776	694	L>*		No	ClinGen gnomAD
rs1216073085 CA384378751	697	S>R		No	ClinGen gnomAD
TCGA novel	697	S>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs202117269 CA6511387	698	E>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6511386 rs188241882	699	E>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6511385 rs764057994	701	Q>K		No	ClinGen ExAC gnomAD
CA384378715 rs1446696329	702	K>N		No	ClinGen TOPMed
rs1295887385 CA384378695	705	S>F		No	ClinGen gnomAD
rs1461095524 CA384378675	709	G>R		No	ClinGen gnomAD
CA6511383 rs752634658	712	K>Q		No	ClinGen ExAC TOPMed gnomAD
rs765058939 CA6511382	713	M>I		No	ClinGen ExAC gnomAD
CA384378635 rs1384960293	714	Q>H		No	ClinGen gnomAD
CA6511381 rs759289660	714	Q>K		No	ClinGen ExAC TOPMed gnomAD
rs1400383157 CA384378632	715	Q>*		No	ClinGen TOPMed
CA384378630 rs1184597778	715	Q>R		No	ClinGen gnomAD
CA384378606 rs1385068742	718	N>K		No	ClinGen TOPMed gnomAD
rs1384475973 CA688639896	719	E>A		No	ClinGen TOPMed
rs1481025060 CA384378559	725	G>E		No	ClinGen gnomAD
CA235279133 rs868764462	726	E>D		No	ClinGen Ensembl
rs1206474793 CA384378538	728	S>*		No	ClinGen gnomAD
rs931933135 CA384378529	730	L>M		No	ClinGen gnomAD
CA235279115 rs931933135	730	L>V		No	ClinGen gnomAD
CA384378513 rs1314018240	732	T>K		No	ClinGen gnomAD
rs533410932 CA6511377	733	I>T		No	ClinGen 1000Genomes ExAC
CA384378483 rs920153642	736	E>D		No	ClinGen TOPMed gnomAD
rs541565694 CA6511374	737	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1326029150 CA384378471	738	E>G		No	ClinGen gnomAD
rs572444310 CA235279100	738	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1456200979 CA384378464	739	T>I		No	ClinGen TOPMed gnomAD
rs1396534312 CA384378459	740	S>A		No	ClinGen gnomAD
CA6511372 rs746243559	740	S>F		No	ClinGen ExAC gnomAD
rs1396534312 CA384378460	740	S>P		No	ClinGen gnomAD
rs746243559 CA6511373	740	S>Y		No	ClinGen ExAC gnomAD
VAR_062664	244	Q>K	a pancreatic ductal adenocarcinoma sample; somatic mutation [UniProt]	No	UniProt

No associated diseases with Q9UBJ2

4 regional properties for Q9UBJ2

Type	Name	Position	InterPro Accession
domain	ABC transporter-like, ATP-binding domain	478 - 704	IPR003439
domain	AAA+ ATPase domain	503 - 689	IPR003593
domain	ABC transporter type 1, transmembrane domain	91 - 365	IPR011527
conserved_site	ABC transporter-like, conserved site	609 - 623	IPR017871

Functions

		Description
EC Number
Subcellular Localization	Peroxisome membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
peroxisomal membrane	The lipid bilayer surrounding a peroxisome.
peroxisome	A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.

8 GO annotations of molecular function

Name	Definition
ABC-type transporter activity	Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane.
acyl-CoA hydrolase activity	Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate.
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATPase-coupled transmembrane transporter activity	Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source.
long-chain fatty acid transporter activity	Enables the transfer of long-chain fatty acids from one side of a membrane to the other. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
protein heterodimerization activity	Binding to a nonidentical protein to form a heterodimer.
protein homodimerization activity	Binding to an identical protein to form a homodimer.

12 GO annotations of biological process

Name	Definition
fatty acid beta-oxidation	A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
long-chain fatty acid import into peroxisome	The directed movement of long-chain fatty acids into a peroxisome. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
myelin maintenance	The process of preserving the structure and function of mature myelin. This includes maintaining the compact structure of myelin necessary for its electrical insulating characteristics as well as the structure of non-compact regions such as Schmidt-Lantermann clefts and paranodal loops. This does not include processes responsible for maintaining the nodes of Ranvier, which are not part of the myelin sheath.
negative regulation of cytokine production involved in inflammatory response	Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response.
negative regulation of reactive oxygen species biosynthetic process	Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species biosynthetic process.
neuron projection maintenance	The organization process that preserves a neuron projection in a stable functional or structural state. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
peroxisome organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.
positive regulation of fatty acid beta-oxidation	Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation.
positive regulation of unsaturated fatty acid biosynthetic process	Any process that activates or increases the frequency, rate or extent of unsaturated fatty acid biosynthetic process.
response to bacterium	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
very long-chain fatty acid catabolic process	The chemical reactions and pathways resulting in the breakdown of a fatty acid which has a chain length greater than C22.
very long-chain fatty acid metabolic process	The chemical reactions and pathways involving a fatty acid which has a chain length greater than C22.

11 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P34230	PXA2	Peroxisomal long-chain fatty acid import protein 1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P31826	yddA	Inner membrane ABC transporter ATP-binding protein YddA	Escherichia coli (strain K12)	PR
P33897	ABCD1	ATP-binding cassette sub-family D member 1	Homo sapiens (Human)	PR
O14678	ABCD4	Lysosomal cobalamin transporter ABCD4	Homo sapiens (Human)	PR
P28288	ABCD3	ATP-binding cassette sub-family D member 3	Homo sapiens (Human)	PR
P48410	Abcd1	ATP-binding cassette sub-family D member 1	Mus musculus (Mouse)	PR
O89016	Abcd4	Lysosomal cobalamin transporter ABCD4	Mus musculus (Mouse)	PR
P55096	Abcd3	ATP-binding cassette sub-family D member 3	Mus musculus (Mouse)	PR
Q61285	Abcd2	ATP-binding cassette sub-family D member 2	Mus musculus (Mouse)	PR
P16970	Abcd3	ATP-binding cassette sub-family D member 3	Rattus norvegicus (Rat)	PR
Q9QY44	Abcd2	ATP-binding cassette sub-family D member 2	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MTHMLNAAAD	RVKWTRSSAA	KRAACLVAAA	YALKTLYPII	GKRLKQSGHG	KKKAAAYPAA
70	80	90	100	110	120
ENTEILHCTE	TICEKPSPGV	NADFFKQLLE	LRKILFPKLV	TTETGWLCLH	SVALISRTFL
130	140	150	160	170	180
SIYVAGLDGK	IVKSIVEKKP	RTFIIKLIKW	LMIAIPATFV	NSAIRYLECK	LALAFRTRLV
190	200	210	220	230	240
DHAYETYFTN	QTYYKVINMD	GRLANPDQSL	TEDIMMFSQS	VAHLYSNLTK	PILDVMLTSY
250	260	270	280	290	300
TLIQTATSRG	ASPIGPTLLA	GLVVYATAKV	LKACSPKFGK	LVAEEAHRKG	YLRYVHSRII
310	320	330	340	350	360
ANVEEIAFYR	GHKVEMKQLQ	KSYKALADQM	NLILSKRLWY	IMIEQFLMKY	VWSSSGLIMV
370	380	390	400	410	420
AIPIITATGF	ADGEDGQKQV	MVSERTEAFT	TARNLLASGA	DAIERIMSSY	KEVTELAGYT
430	440	450	460	470	480
ARVYNMFWVF	DEVKRGIYKR	TAVIQESESH	SKNGAKVELP	LSDTLAIKGK	VIDVDHGIIC
490	500	510	520	530	540
ENVPIITPAG	EVVASRLNFK	VEEGMHLLIT	GPNGCGKSSL	FRILSGLWPV	YEGVLYKPPP
550	560	570	580	590	600
QHMFYIPQRP	YMSLGSLRDQ	VIYPDSVDDM	HDKGYTDQDL	ERILHNVHLY	HIVQREGGWD
610	620	630	640	650	660
AVMDWKDVLS	GGEKQRMGMA	RMFYHKPKYA	LLDECTSAVS	IDVEGKIFQA	AKGAGISLLS
670	680	690	700	710	720
ITHRPSLWKY	HTHLLQFDGE	GGWRFEQLDT	AIRLTLSEEK	QKLESQLAGI	PKMQQRLNEL
730
CKILGEDSVL	KTIKNEDETS