Q61285

PR
Gene name
Abcd2 (Aldr)
Protein name
ATP-binding cassette sub-family D member 2
Names
Adrenoleukodystrophy-related protein
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:26874
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

20-104 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q61285

Entry ID Method Resolution Chain Position Source
AF-Q61285-F1 Predicted AlphaFoldDB

37 variants for Q61285

Variant ID(s) Position Change Description Diseaes Association Provenance
rs241772207 55 E>D No EVA
rs212664634 58 S>P No EVA
rs3389352849 63 R>K No EVA
rs3389382310 111 S>P No EVA
rs232370491 139 K>N No EVA
rs3406415451 148 I>S No EVA
rs3389346472 161 N>S No EVA
rs3389352808 164 I>V No EVA
rs3389346395 165 R>W No EVA
rs32013322 172 A>T No EVA
rs3389352835 173 L>F No EVA
rs3389362947 203 L>M No EVA
rs3389346414 215 M>T No EVA
rs3389374780 232 I>F No EVA
rs3389352832 233 L>I No EVA
rs3389382307 245 T>I No EVA
rs3389381577 246 A>T No EVA
rs3389381567 289 K>N No EVA
rs3389352782 342 M>K No EVA
rs3389398406 367 A>V No EVA
rs3389378808 371 A>E No EVA
rs3389346471 372 D>Y No EVA
rs3389378799 428 M>L No EVA
rs3389346419 431 V>I No EVA
rs220989435 433 D>E No EVA
rs241829459 433 D>N No EVA
rs260632294 439 I>V No EVA
rs32005169 450 N>S No EVA
rs251947364 452 S>T No EVA
rs32005167 454 R>H No EVA
rs253344605 462 L>F No EVA
rs3404850128 506 M>I No EVA
rs3404850134 507 H>Q No EVA
rs259468172 572 R>H No EVA
rs3389346389 624 F>S No EVA
rs3406789210 679 D>A No EVA
rs31591983 737 A>P No EVA

No associated diseases with Q61285

4 regional properties for Q61285

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 478 - 704 IPR003439
domain AAA+ ATPase domain 503 - 689 IPR003593
domain ABC transporter type 1, transmembrane domain 91 - 365 IPR011527
conserved_site ABC transporter-like, conserved site 609 - 623 IPR017871

Functions

Description
EC Number
Subcellular Localization
  • Peroxisome membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
peroxisomal membrane The lipid bilayer surrounding a peroxisome.
peroxisome A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.

8 GO annotations of molecular function

Name Definition
ABC-type transporter activity Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane.
acyl-CoA hydrolase activity Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATPase-coupled transmembrane transporter activity Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source.
long-chain fatty acid transporter activity Enables the transfer of long-chain fatty acids from one side of a membrane to the other. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
protein heterodimerization activity Binding to a nonidentical protein to form a heterodimer.
protein homodimerization activity Binding to an identical protein to form a homodimer.

12 GO annotations of biological process

Name Definition
fatty acid beta-oxidation A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
long-chain fatty acid import into peroxisome The directed movement of long-chain fatty acids into a peroxisome. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
myelin maintenance The process of preserving the structure and function of mature myelin. This includes maintaining the compact structure of myelin necessary for its electrical insulating characteristics as well as the structure of non-compact regions such as Schmidt-Lantermann clefts and paranodal loops. This does not include processes responsible for maintaining the nodes of Ranvier, which are not part of the myelin sheath.
negative regulation of cytokine production involved in inflammatory response Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response.
negative regulation of reactive oxygen species biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species biosynthetic process.
neuron projection maintenance The organization process that preserves a neuron projection in a stable functional or structural state. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
peroxisome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.
positive regulation of fatty acid beta-oxidation Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation.
positive regulation of unsaturated fatty acid biosynthetic process Any process that activates or increases the frequency, rate or extent of unsaturated fatty acid biosynthetic process.
response to bacterium Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
very long-chain fatty acid catabolic process The chemical reactions and pathways resulting in the breakdown of a fatty acid which has a chain length greater than C22.
very long-chain fatty acid metabolic process The chemical reactions and pathways involving a fatty acid which has a chain length greater than C22.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P34230 PXA2 Peroxisomal long-chain fatty acid import protein 1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P31826 yddA Inner membrane ABC transporter ATP-binding protein YddA Escherichia coli (strain K12) PR
P33897 ABCD1 ATP-binding cassette sub-family D member 1 Homo sapiens (Human) PR
Q9UBJ2 ABCD2 ATP-binding cassette sub-family D member 2 Homo sapiens (Human) PR
P48410 Abcd1 ATP-binding cassette sub-family D member 1 Mus musculus (Mouse) PR
P55096 Abcd3 ATP-binding cassette sub-family D member 3 Mus musculus (Mouse) PR
O89016 Abcd4 Lysosomal cobalamin transporter ABCD4 Mus musculus (Mouse) PR
Q9QY44 Abcd2 ATP-binding cassette sub-family D member 2 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MIHMLNAAAY RVKWTRSGAA KRAACLVAAA YALKTLYPII GKRLKQPGHR KAKAEAYSPA
70 80 90 100 110 120
ENREILHCTE IICKKPAPGL NAAFFKQLLE LRKILFPKLV TTETGWLCLH SVALISRTFL
130 140 150 160 170 180
SIYVAGLDGK IVKSIVEKKP RTFIIKLIKW LMIAIPATFV NSAIRYLECK LALAFRTRLV
190 200 210 220 230 240
DHAYETYFAN QTYYKVINMD GRLANPDQSL TEDIMMFSQS VAHLYSNLTK PILDVILTSY
250 260 270 280 290 300
TLIRTATSRG ASPIGPTLLA GLVVYATAKV LKACSPKFGS LVAEEAHRKG YLRYVHSRII
310 320 330 340 350 360
ANVEEIAFYR GHKVEMKQLQ KCYKALAYQM NLILSKRLWY IMIEQFLMKY VWSSCGLIMV
370 380 390 400 410 420
AIPIITATGF ADGDLEDGPK QAMVSDRTEA FTTARNLLAS GADAIERIMS SYKEITELAG
430 440 450 460 470 480
YTARVYNMFW VFDEVKRGIY KRTVTQEPEN HSKRGGNLEL PLSDTLAIKG TVIDVDHGII
490 500 510 520 530 540
CENVPIITPA GEVVASRLNF KVEEGMHLLI TGPNGCGKSS LFRILSGLWP VYEGVLYKPP
550 560 570 580 590 600
PQHMFYIPQR PYMSLGSLRD QVIYPDSADD MREKGYTDQD LERILHSVHL YHIVQREGGW
610 620 630 640 650 660
DAVMDWKDVL SGGEKQRMGM ARMFYHKPKY ALLDECTSAV SIDVEGKIFQ AAIGAGISLL
670 680 690 700 710 720
SITHRPSLWK YHTHLLQFDG EGGWRFEQLD TAIRLTLSEE KQKLESQLAG IPKMQQRLNE
730 740
LCKILGEDSV LKTIQTAEKT S