Q9QY44
PR
Gene name |
Abcd2 (Aldr) |
Protein name |
ATP-binding cassette sub-family D member 2 |
Names |
Adrenoleukodystrophy-related protein |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:84356 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9QY44
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9QY44-F1 | Predicted | AlphaFoldDB |
1 variants for Q9QY44
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs105087129 | 455 | R>G | No | EVA |
No associated diseases with Q9QY44
4 regional properties for Q9QY44
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| peroxisomal membrane | The lipid bilayer surrounding a peroxisome. |
| peroxisome | A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. |
8 GO annotations of molecular function
| Name | Definition |
|---|---|
| ABC-type transporter activity | Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane. |
| acyl-CoA hydrolase activity | Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| ATPase-coupled transmembrane transporter activity | Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source. |
| long-chain fatty acid transporter activity | Enables the transfer of long-chain fatty acids from one side of a membrane to the other. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. |
| protein heterodimerization activity | Binding to a nonidentical protein to form a heterodimer. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
12 GO annotations of biological process
| Name | Definition |
|---|---|
| fatty acid beta-oxidation | A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). |
| long-chain fatty acid import into peroxisome | The directed movement of long-chain fatty acids into a peroxisome. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. |
| myelin maintenance | The process of preserving the structure and function of mature myelin. This includes maintaining the compact structure of myelin necessary for its electrical insulating characteristics as well as the structure of non-compact regions such as Schmidt-Lantermann clefts and paranodal loops. This does not include processes responsible for maintaining the nodes of Ranvier, which are not part of the myelin sheath. |
| negative regulation of cytokine production involved in inflammatory response | Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response. |
| negative regulation of reactive oxygen species biosynthetic process | Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species biosynthetic process. |
| neuron projection maintenance | The organization process that preserves a neuron projection in a stable functional or structural state. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| peroxisome organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. |
| positive regulation of fatty acid beta-oxidation | Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation. |
| positive regulation of unsaturated fatty acid biosynthetic process | Any process that activates or increases the frequency, rate or extent of unsaturated fatty acid biosynthetic process. |
| response to bacterium | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. |
| very long-chain fatty acid catabolic process | The chemical reactions and pathways resulting in the breakdown of a fatty acid which has a chain length greater than C22. |
| very long-chain fatty acid metabolic process | The chemical reactions and pathways involving a fatty acid which has a chain length greater than C22. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P34230 | PXA2 | Peroxisomal long-chain fatty acid import protein 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P31826 | yddA | Inner membrane ABC transporter ATP-binding protein YddA | Escherichia coli (strain K12) | PR |
| P33897 | ABCD1 | ATP-binding cassette sub-family D member 1 | Homo sapiens (Human) | PR |
| Q9UBJ2 | ABCD2 | ATP-binding cassette sub-family D member 2 | Homo sapiens (Human) | PR |
| P48410 | Abcd1 | ATP-binding cassette sub-family D member 1 | Mus musculus (Mouse) | PR |
| Q61285 | Abcd2 | ATP-binding cassette sub-family D member 2 | Mus musculus (Mouse) | PR |
| P16970 | Abcd3 | ATP-binding cassette sub-family D member 3 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MIHMLNAAAY | RVKWTRSGAA | KRAACLVAAA | YALKTLYPIL | GRRLKQPGHR | KAKAEDYPPA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ENRERLHCTE | IICKKPAPGL | NADFFKQLLE | LRKILFPKLV | TTETGWLCLH | SVALISRTFL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SIYVAGLDGK | IVKSIVEKKP | RTFIIKLVKW | LMIAVPATFV | NSAIRYLECK | LALAFRTRLV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DHAYETYFAN | QTYYKVINMD | GRLANPDQSL | TEDIMMFSQS | VAHLYSNLTK | PILDVILTSY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TLIRTATSRG | ASPIGPTLLA | GLVVYATAKV | LKACSPKFGT | LVAEEAHRKG | YLRYVHSRII |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ANVEEIAFYR | GHKVEMKQLQ | KCYKALAYQM | NLILSKRLWY | IMIEQFLMKY | VWSGCGLIMV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AIPIITATGF | ADGDLEDGPK | QAMVSDRTEA | FTTARNLLAS | GADAIERIMS | SYKEITELAG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YTARVYNMFW | VFDEVKRGIY | KRTVTQEPEN | NSKSRGGLEL | PLSDTLAIKG | TVIDVDHGIL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| CENVPIITPA | GEVVASSLNF | KVEEGMHLLI | TGPNGCGKSS | LFRILSGLWP | VYEGVLYKPP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PQHMFYIPQR | PYMSLGSLRD | QVIYPDSVDD | MHEKGYTDRD | LEHILHSVHL | YHIVQREGGW |
| 610 | 620 | 630 | 640 | 650 | 660 |
| DAVMDWKDVL | SGGEKQRMGM | ARMFYHKPKY | ALLDECTSAV | SIDVEGKIFQ | AAIGAGISLL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| SITHRPSLWK | YHTHLLQFDG | EGGWRFEQLD | TAIRLTLSEE | KQKLESQLAG | IPKMQQRLNE |
| 730 | 740 | ||||
| LCKILGEDSV | LKTIQTAEDT | S |