Q9TZM3
SS
Gene name |
lrk-1 (T27C10.6) |
Protein name |
Leucine-rich repeat serine/threonine-protein kinase 1 |
Names |
EC 2.7.11.1 , Leucine-rich repeats, ras-like domain, kinase protein 1 , PARK8-related kinase |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_T27C10.6 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
Leucine-rich repeat serine/threonine-protein kinase 1 (LRRK1) is a protein involved in the negative regulation of bone mass, acting through the maturation of osteoclasts. In contrast to the mechanism of autoinhibition that occurs in LRRK2, the autoinhibition of LRRK1 is mediated by a steric mechanism involving the ANK domain, which blocks access to the active site of the kinase domain in a dimer-dependent manner. In contrast, the interaction of the N-terminal LRR domain with the N-lobe of the kinase domain contributes to the alleviation of autoinhibition by changing its position relative to the WD40 domain, exposing the exposure of the active site of the kinase domain. The autoinhibited dimer of LRRK1 could be stabilized by a loop (1791-1907) in the WD40 domain. In addition, the kinase activity of LRRK1 is also regulated by the interaction of its COR-B loop with the kinase domain. Phosphorylation of three residues (S1064, T1074, and S1075) in the autoinhibitory COR-B loop significantly increases the kinase activity of LRRK1. Phosphorylation by Rab7a, resulting in the F1065A mutation, also alleviates the autoinhibited state of LRRK1.
Autoinhibitory domains (AIDs)
Target domain |
1719-1721 (N-lobe of kinase domain) |
Relief mechanism |
Partner binding, Cleavage |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9TZM3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9TZM3-F1 | Predicted | AlphaFoldDB |
No variants for Q9TZM3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9TZM3 | |||||
No associated diseases with Q9TZM3
16 regional properties for Q9TZM3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 1694 - 1992 | IPR000719 |
| repeat | Leucine-rich repeat | 555 - 576 | IPR001611-1 |
| repeat | Leucine-rich repeat | 580 - 638 | IPR001611-2 |
| repeat | Ankyrin repeat | 56 - 150 | IPR002110-1 |
| repeat | Ankyrin repeat | 197 - 293 | IPR002110-2 |
| repeat | Ankyrin repeat | 310 - 393 | IPR002110-3 |
| repeat | Ankyrin repeat | 407 - 437 | IPR002110-4 |
| repeat | Leucine-rich repeat, typical subtype | 530 - 553 | IPR003591-1 |
| repeat | Leucine-rich repeat, typical subtype | 579 - 601 | IPR003591-2 |
| repeat | Leucine-rich repeat, typical subtype | 602 - 625 | IPR003591-3 |
| repeat | Leucine-rich repeat, typical subtype | 626 - 650 | IPR003591-4 |
| repeat | Leucine-rich repeat, typical subtype | 740 - 763 | IPR003591-5 |
| repeat | Leucine-rich repeat, typical subtype | 854 - 878 | IPR003591-6 |
| repeat | Leucine-rich repeat, typical subtype | 881 - 904 | IPR003591-7 |
| domain | Roc domain | 969 - 1167 | IPR020859 |
| domain | C-terminal of Roc (COR) domain | 1233 - 1422 | IPR032171 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| neuronal cell body | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| GTP binding | Binding to GTP, guanosine triphosphate. |
| metal ion binding | Binding to a metal ion. |
| protein serine kinase activity | Catalysis of the reactions |
| protein serine/threonine kinase activity | Catalysis of the reactions |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| axon extension involved in axon guidance | The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues. |
| negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | Any process that stops, prevents or reduces the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| protein localization | Any process in which a protein is transported to, or maintained in, a specific location. |
| response to endoplasmic reticulum stress | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. |
| response to oxidative stress | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. |
| synaptic vesicle transport | The directed movement of synaptic vesicles. |
91 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A2VDU3 | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | Bos taurus (Bovine) | SS |
| Q4TVR5 | DSTYK | Dual serine/threonine and tyrosine protein kinase | Bos taurus (Bovine) | PR |
| Q3SZJ2 | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2 | Bos taurus (Bovine) | PR |
| Q3MHH9 | ECM2 | Extracellular matrix protein 2 | Bos taurus (Bovine) | PR |
| P58874 | OPTC | Opticin | Bos taurus (Bovine) | PR |
| Q24K06 | LRRC10 | Leucine-rich repeat-containing protein 10 | Bos taurus (Bovine) | PR |
| Q6XUX0 | DSTYK | Dual serine/threonine and tyrosine protein kinase | Gallus gallus (Chicken) | PR |
| Q04861 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | Gallus gallus (Chicken) | SS |
| P98150 | NFKB2 | Nuclear factor NF-kappa-B p100 subunit | Gallus gallus (Chicken) | SS |
| P83104 | Takl1 | Putative mitogen-activated protein kinase kinase kinase 7-like | Drosophila melanogaster (Fruit fly) | PR |
| Q95UN8 | slpr | Mitogen-activated protein kinase kinase kinase | Drosophila melanogaster (Fruit fly) | EV |
| Q94527 | Rel | Nuclear factor NF-kappa-B p110 subunit | Drosophila melanogaster (Fruit fly) | EV |
| Q9V780 | Lap1 | Protein lap1 | Drosophila melanogaster (Fruit fly) | PR |
| O43353 | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2 | Homo sapiens (Human) | PR |
| Q02779 | MAP3K10 | Mitogen-activated protein kinase kinase kinase 10 | Homo sapiens (Human) | SS |
| Q8NB16 | MLKL | Mixed lineage kinase domain-like protein | Homo sapiens (Human) | EV |
| Q16584 | MAP3K11 | Mitogen-activated protein kinase kinase kinase 11 | Homo sapiens (Human) | EV |
| P00540 | MOS | Proto-oncogene serine/threonine-protein kinase mos | Homo sapiens (Human) | PR |
| Q5TCX8 | MAP3K21 | Mitogen-activated protein kinase kinase kinase 21 | Homo sapiens (Human) | PR |
| Q6XUX3 | DSTYK | Dual serine/threonine and tyrosine protein kinase | Homo sapiens (Human) | PR |
| O43318 | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | Homo sapiens (Human) | SS |
| Q9NYL2 | MAP3K20 | Mitogen-activated protein kinase kinase kinase 20 | Homo sapiens (Human) | PR |
| P80192 | MAP3K9 | Mitogen-activated protein kinase kinase kinase 9 | Homo sapiens (Human) | SS |
| P19838 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | Homo sapiens (Human) | SS |
| Q99549 | MPHOSPH8 | M-phase phosphoprotein 8 | Homo sapiens (Human) | PR |
| Q00653 | NFKB2 | Nuclear factor NF-kappa-B p100 subunit | Homo sapiens (Human) | SS |
| Q8N9B4 | ANKRD42 | Ankyrin repeat domain-containing protein 42 | Homo sapiens (Human) | PR |
| Q6ZVZ8 | ASB18 | Ankyrin repeat and SOCS box protein 18 | Homo sapiens (Human) | PR |
| Q96NW7 | LRRC7 | Leucine-rich repeat-containing protein 7 | Homo sapiens (Human) | PR |
| Q8IWT6 | LRRC8A | Volume-regulated anion channel subunit LRRC8A | Homo sapiens (Human) | PR |
| Q9HCJ2 | LRRC4C | Leucine-rich repeat-containing protein 4C | Homo sapiens (Human) | PR |
| Q9UFC0 | LRWD1 | Leucine-rich repeat and WD repeat-containing protein 1 | Homo sapiens (Human) | PR |
| Q96L50 | LRR1 | Leucine-rich repeat protein 1 | Homo sapiens (Human) | PR |
| Q86UN2 | RTN4RL1 | Reticulon-4 receptor-like 1 | Homo sapiens (Human) | PR |
| Q8IWK6 | ADGRA3 | Adhesion G protein-coupled receptor A3 | Homo sapiens (Human) | PR |
| Q7L1W4 | LRRC8D | Volume-regulated anion channel subunit LRRC8D | Homo sapiens (Human) | PR |
| Q96FE5 | LINGO1 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 | Homo sapiens (Human) | PR |
| Q8TDW0 | LRRC8C | Volume-regulated anion channel subunit LRRC8C | Homo sapiens (Human) | PR |
| Q38SD2 | LRRK1 | Leucine-rich repeat serine/threonine-protein kinase 1 | Homo sapiens (Human) | EV |
| Q80XI6 | Map3k11 | Mitogen-activated protein kinase kinase kinase 11 | Mus musculus (Mouse) | PR |
| Q8VDG6 | Map3k21 | Mitogen-activated protein kinase kinase kinase 21 | Mus musculus (Mouse) | PR |
| P58801 | Ripk2 | Receptor-interacting serine/threonine-protein kinase 2 | Mus musculus (Mouse) | PR |
| Q62073 | Map3k7 | Mitogen-activated protein kinase kinase kinase 7 | Mus musculus (Mouse) | EV |
| Q3U1V8 | Map3k9 | Mitogen-activated protein kinase kinase kinase 9 | Mus musculus (Mouse) | SS |
| Q9D2Y4 | Mlkl | Mixed lineage kinase domain-like protein | Mus musculus (Mouse) | SS |
| Q9ESL4 | Map3k20 | Mitogen-activated protein kinase kinase kinase 20 | Mus musculus (Mouse) | PR |
| P00536 | Mos | Proto-oncogene serine/threonine-protein kinase mos | Mus musculus (Mouse) | PR |
| Q66L42 | Map3k10 | Mitogen-activated protein kinase kinase kinase 10 | Mus musculus (Mouse) | SS |
| Q9CZK6 | Anks3 | Ankyrin repeat and SAM domain-containing protein 3 | Mus musculus (Mouse) | PR |
| P25799 | Nfkb1 | Nuclear factor NF-kappa-B p105 subunit [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] | Mus musculus (Mouse) | EV |
| Q8VHA6 | Asb18 | Ankyrin repeat and SOCS box protein 18 | Mus musculus (Mouse) | PR |
| Q9WTK5 | Nfkb2 | Nuclear factor NF-kappa-B p100 subunit [Cleaved into: Nuclear factor NF-kappa-B p52 subunit] | Mus musculus (Mouse) | EV |
| A6H694 | Lrrc63 | Leucine-rich repeat-containing protein 63 | Mus musculus (Mouse) | PR |
| Q9D9Q0 | Lrrc69 | Leucine-rich repeat-containing protein 69 | Mus musculus (Mouse) | PR |
| Q8BGI7 | Lrrc39 | Leucine-rich repeat-containing protein 39 | Mus musculus (Mouse) | PR |
| Q7TT36 | Adgra3 | Adhesion G protein-coupled receptor A3 | Mus musculus (Mouse) | PR |
| P59383 | Lrrn4 | Leucine-rich repeat neuronal protein 4 | Mus musculus (Mouse) | PR |
| Q9D1T0 | Lingo1 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 | Mus musculus (Mouse) | PR |
| Q8R502 | Lrrc8c | Volume-regulated anion channel subunit LRRC8C | Mus musculus (Mouse) | PR |
| Q80WG5 | Lrrc8a | Volume-regulated anion channel subunit LRRC8A | Mus musculus (Mouse) | PR |
| Q8K0S5 | Rtn4rl1 | Reticulon-4 receptor-like 1 | Mus musculus (Mouse) | PR |
| Q80TE7 | Lrrc7 | Leucine-rich repeat-containing protein 7 | Mus musculus (Mouse) | PR |
| Q5DU41 | Lrrc8b | Volume-regulated anion channel subunit LRRC8B | Mus musculus (Mouse) | PR |
| Q5RKR3 | Islr2 | Immunoglobulin superfamily containing leucine-rich repeat protein 2 | Mus musculus (Mouse) | PR |
| Q8C031 | Lrrc4c | Leucine-rich repeat-containing protein 4C | Mus musculus (Mouse) | PR |
| P0C8E4 | Map3k7 | Mitogen-activated protein kinase kinase kinase 7 | Rattus norvegicus (Rat) | SS |
| Q66HA1 | Map3k11 | Mitogen-activated protein kinase kinase kinase 11 | Rattus norvegicus (Rat) | PR |
| D3ZG83 | Map3k10 | Mitogen-activated protein kinase kinase kinase 10 | Rattus norvegicus (Rat) | SS |
| P00539 | Mos | Proto-oncogene serine/threonine-protein kinase mos | Rattus norvegicus (Rat) | PR |
| P70587 | Lrrc7 | Leucine-rich repeat-containing protein 7 | Rattus norvegicus (Rat) | PR |
| Q4V8G0 | Lrrc63 | Leucine-rich repeat-containing protein 63 | Rattus norvegicus (Rat) | PR |
| Q80WD0 | Rtn4rl1 | Reticulon-4 receptor-like 1 | Rattus norvegicus (Rat) | PR |
| Q9FPR3 | EDR1 | Serine/threonine-protein kinase EDR1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q2MHE4 | HT1 | Serine/threonine/tyrosine-protein kinase HT1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O22558 | STY8 | Serine/threonine-protein kinase STY8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWL6 | STY17 | Serine/threonine-protein kinase STY17 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4JTP5 | STY46 | Serine/threonine-protein kinase STY46 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q05609 | CTR1 | Serine/threonine-protein kinase CTR1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O22265 | CAO | Signal recognition particle 43 kDa protein, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SZI3 | NPR2 | Regulatory protein NPR2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SHI4 | RLP3 | Receptor-like protein 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5G5E0 | PIRL5 | Plant intracellular Ras-group-related LRR protein 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P43298 | TMK1 | Receptor protein kinase TMK1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGE4 | At1g12460 | Probable LRR receptor-like serine/threonine-protein kinase At1g12460 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGJ1 | At1g74360 | Probable LRR receptor-like serine/threonine-protein kinase At1g74360 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q0WR59 | At5g10020 | Probable inactive receptor kinase At5g10020 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LFG1 | At3g53590 | Putative leucine-rich repeat receptor-like serine/threonine-protein kinase At3g53590 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q67E00 | dstyk | Dual serine/threonine and tyrosine protein kinase | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| B0JZ65 | lrwd1 | Leucine-rich repeat and WD repeat-containing protein 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q68F79 | lrrc8e | Volume-regulated anion channel subunit LRRC8E | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| B0R160 | lrwd1 | Leucine-rich repeat and WD repeat-containing protein 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDLSSGGPSS | SSDVASELDN | SDAMQLVRQA | VLFENVELLA | DLFKVNPWVW | NRVDRHGRTP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LMLAAHNGKL | DSLRTILMLS | PNSLNLVNDR | GKTALHMAAE | SGETSIVLEL | VELGSDPMKS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DNEGHCALEL | AQMAGHNEVA | AKLIDAIQKE | SEDLNEAHTM | IISACISGSA | DVVYEISRRF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MEKKQSREIL | FNGRNEEDET | ALLIACTNGH | IEIVRHLLQF | EEHLLQSHVS | KDTVIHAAVS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SQNVEVLQLC | LEKFPQLVKS | TNNEGSTCLH | WAARCGSSEC | VSTILNFPFP | SEFIIEIDTV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GAPAYQLALD | VNEVDGECRT | AMYLAVAEGH | LEVVKAMTDF | KCTSIDGRQR | CPFQLDVYCT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RGRTPFMLAA | FNQNLPLMTL | LLDAGADVNL | PLAVLDTEYS | VEEGRCIGSG | ALVEAVRSDG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LHIVHFLLDR | GALDTDNKAL | RLAAQGKNEK | LIRVFLVRLV | FADPEYKINK | KNIDVGQIQV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GQSLLPSSLC | PSKAAQLNWN | SANLEQLQSD | WFVAAALHVN | PRLRTTRLSL | AAITRVDLSD |
| 550 | 560 | 570 | 580 | 590 | 600 |
| NRLNTFPSIL | FQMPSLRSLN | LADNSIRKIE | IPTYYISSTS | LEILNLRNNQ | LECIAIQFLS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SLPQLQQLDV | SKNELSQLPE | YIWLCPALKE | LNASYNRLST | LPMVARASRG | ERPRLNNSNN |
| 670 | 680 | 690 | 700 | 710 | 720 |
| NFNTQSPTQE | SNPIVVDDPP | NVTSNPLRRQ | NVWQASINLS | KVDDDSLFPD | FPVTSSNTLT |
| 730 | 740 | 750 | 760 | 770 | 780 |
| TINLSFNKFH | TFPFCLACTC | PRLLILNMSN | NSMTSLPPMA | CVPAHLRTLD | LSYNKIQESF |
| 790 | 800 | 810 | 820 | 830 | 840 |
| IEASPLHVVC | HAVPPTTSNG | SMLPKRRNSP | ARQHRSRSKS | AVRSQRSLSV | SRHHALIDPQ |
| 850 | 860 | 870 | 880 | 890 | 900 |
| KEEESCVHKR | HDSLEWLKTL | QLAGNRLRSI | SVTNAASKVL | LPALNVMDIS | DNKLLQAPPD |
| 910 | 920 | 930 | 940 | 950 | 960 |
| VARLTLLSML | NLSGNTAIKE | LPPDYGMLSR | LWSLSLKGCS | LKEPLESMVN | VENCKTVEIV |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| AYLKTILEES | KTYHHLRLMI | LGSDGVGKSV | IWDALCKEAV | QKRQPIHSET | GVIRQAEWKF |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| EAKRSKGDKN | LGPVGFSVID | FGGQREYHST | HQYFLSKRSL | NLVLWKITDG | DEALAQLDTW |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| LVNIHARAPN | STVILVGTNL | DQVASNSSKF | GPGYIDIMEQ | KVRTRYMVAD | ADKSGLPRIV |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| DVILINSTSR | NDVKALLNTI | YRTAWEVRMG | KERAMEQQIP | SSYIALMKVT | KELGVEFRKE |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| GQPAVMTVEA | YRERVKKRMI | SKFGRPFRDD | IEFYAACTFL | HDCGELVRFE | DATLRDLIFV |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| DPLWLAEFLT | SVVILRSPNL | PAGLLSTDAI | NPHTRSFKSG | ALLMLKTQLL | DLLHKFELAL |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| ATQPRQLLIP | SLLPDEYRLR | SDFLASAVKI | RMKMSQWNVR | CPSPAGSPTK | SPLRRTSPTD |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| QNGVGSEDVM | LQFTYDDDQL | LRRIYALAYI | PSGFWSRLVT | RIVGDKNVCA | AIESIFMTTS |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| ADRAKIADIA | TKHAKAEWVV | WQTGIELHVK | GHSLFTLKQF | LPLAEVRDID | YSAIDMRAKD |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| EQKRWRTWNQ | PSHRPIVEMV | VNSLSISAAS | QHGRKLSMKT | DVEGRSRLLA | MISDLLDTLL |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| EDWYPALGTR | FVHSSEGDLL | VSRYVLCPQC | VRDAERNGSR | SRTSSSASHR | RSQDDGELPI |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| TSSSHMKGSR | TTGDISKCRG | GVVHCFVIEE | CMLAGREYNW | VECPSHGGLH | MRELAPDTVF |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| ADIENALTIH | PDQLKRSRML | GRGAFGFVFR | ATVRQPNGEL | CEVAQKMLEP | VDPGPGGRPS |
| 1750 | 1760 | 1770 | 1780 | 1790 | 1800 |
| ALAAYKAAAD | KWKRDSMEFA | CRAYCTSRQE | LSLLSRMKHP | NVIGLVGVCT | FPLSLVVELA |
| 1810 | 1820 | 1830 | 1840 | 1850 | 1860 |
| PLGALNQLLG | SHRKAGTKLS | LGVIKESAVQ | VARALEYLHS | AHIIYRDLKS | ENVLGWRFPA |
| 1870 | 1880 | 1890 | 1900 | 1910 | 1920 |
| PFSPQTDVLL | KLGDYGISRS | VLPSGGAKGF | GGTEGFMAPE | IVRFNGEEEY | TQKVDCFSFG |
| 1930 | 1940 | 1950 | 1960 | 1970 | 1980 |
| MFLYELLTLK | FPFESEEHVK | ERMLDGARPV | LLPHELLLPT | PMLDLLVHCW | SAHPESRPSS |
| 1990 | 2000 | 2010 | 2020 | 2030 | 2040 |
| SQLVGFCAAP | EFTHLLDVCE | LGEALPPTQL | MAVGITDEID | DPDDFEAQLW | LSGREMVVMG |
| 2050 | 2060 | 2070 | 2080 | 2090 | 2100 |
| CTQYGFVDQK | SIELPHRGKY | VSKVRDSVWS | CDECGQVTVY | GISLHETGHL | QLPSLNGTLI |
| 2110 | 2120 | 2130 | 2140 | 2150 | 2160 |
| CAPELISNDV | LILISDKQIV | LLKLSESNSV | SHLGTIDSPY | EIRTATFLGN | GSTRQIWAGH |
| 2170 | 2180 | 2190 | 2200 | 2210 | 2220 |
| SEGRISIHHI | ASNDSFSFSS | SLYLPDDKCI | VRQLVGSKDA | QKVWIALEKS | SKVQMVEVEK |
| 2230 | 2240 | 2250 | 2260 | 2270 | 2280 |
| RQVTGSLDIR | KVMPGSETIH | TIDMEMASQN | YVTCIGLLER | NDGDQLYIGT | SKGLLVIAHA |
| 2290 | 2300 | 2310 | 2320 | 2330 | 2340 |
| TTLQPLSACR | PFEGDITSIC | ILEEPSREEE | NTRGKATTLS | TASSESGLGW | VRERVSETVD |
| 2350 | 2360 | 2370 | 2380 | 2390 | |
| RFRSSPATVE | TQGAALVVCI | GRQFRSLSHR | FVAEEKLADV | YSIAVWRTEE | WAL |