Q3MHH9
PR
Gene name |
ECM2 |
Protein name |
Extracellular matrix protein 2 |
Names |
|
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:533916 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3MHH9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3MHH9-F1 | Predicted | AlphaFoldDB |
No variants for Q3MHH9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q3MHH9 | |||||
No associated diseases with Q3MHH9
16 regional properties for Q3MHH9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | VWFC domain | 100 - 157 | IPR001007 |
| repeat | Leucine-rich repeat | 324 - 386 | IPR001611-1 |
| repeat | Leucine-rich repeat | 395 - 431 | IPR001611-2 |
| repeat | Leucine-rich repeat | 467 - 538 | IPR001611-3 |
| repeat | Leucine-rich repeat | 562 - 624 | IPR001611-4 |
| repeat | Leucine-rich repeat, typical subtype | 324 - 346 | IPR003591-1 |
| repeat | Leucine-rich repeat, typical subtype | 347 - 372 | IPR003591-2 |
| repeat | Leucine-rich repeat, typical subtype | 373 - 396 | IPR003591-3 |
| repeat | Leucine-rich repeat, typical subtype | 418 - 443 | IPR003591-4 |
| repeat | Leucine-rich repeat, typical subtype | 444 - 467 | IPR003591-5 |
| repeat | Leucine-rich repeat, typical subtype | 469 - 488 | IPR003591-6 |
| repeat | Leucine-rich repeat, typical subtype | 516 - 538 | IPR003591-7 |
| repeat | Leucine-rich repeat, typical subtype | 539 - 559 | IPR003591-8 |
| repeat | Leucine-rich repeat, typical subtype | 588 - 610 | IPR003591-9 |
| repeat | Leucine-rich repeat, typical subtype | 611 - 635 | IPR003591-10 |
| repeat | Leucine-rich repeat, typical subtype | 641 - 665 | IPR003591-11 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular matrix | A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues. |
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| collagen V binding | Binding to a type V collagen trimer. |
| heparin binding | Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| extracellular matrix organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix. |
| positive regulation of cell-substrate adhesion | Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules. |
36 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P58874 | OPTC | Opticin | Bos taurus (Bovine) | PR |
| Q24K06 | LRRC10 | Leucine-rich repeat-containing protein 10 | Bos taurus (Bovine) | PR |
| Q9V780 | Lap1 | Protein lap1 | Drosophila melanogaster (Fruit fly) | PR |
| Q96NW7 | LRRC7 | Leucine-rich repeat-containing protein 7 | Homo sapiens (Human) | PR |
| Q8IWT6 | LRRC8A | Volume-regulated anion channel subunit LRRC8A | Homo sapiens (Human) | PR |
| Q9HCJ2 | LRRC4C | Leucine-rich repeat-containing protein 4C | Homo sapiens (Human) | PR |
| Q9UFC0 | LRWD1 | Leucine-rich repeat and WD repeat-containing protein 1 | Homo sapiens (Human) | PR |
| Q96L50 | LRR1 | Leucine-rich repeat protein 1 | Homo sapiens (Human) | PR |
| Q86UN2 | RTN4RL1 | Reticulon-4 receptor-like 1 | Homo sapiens (Human) | PR |
| Q8IWK6 | ADGRA3 | Adhesion G protein-coupled receptor A3 | Homo sapiens (Human) | PR |
| Q7L1W4 | LRRC8D | Volume-regulated anion channel subunit LRRC8D | Homo sapiens (Human) | PR |
| Q96FE5 | LINGO1 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 | Homo sapiens (Human) | PR |
| Q8TDW0 | LRRC8C | Volume-regulated anion channel subunit LRRC8C | Homo sapiens (Human) | PR |
| Q38SD2 | LRRK1 | Leucine-rich repeat serine/threonine-protein kinase 1 | Homo sapiens (Human) | EV |
| A6H694 | Lrrc63 | Leucine-rich repeat-containing protein 63 | Mus musculus (Mouse) | PR |
| Q9D9Q0 | Lrrc69 | Leucine-rich repeat-containing protein 69 | Mus musculus (Mouse) | PR |
| Q8BGI7 | Lrrc39 | Leucine-rich repeat-containing protein 39 | Mus musculus (Mouse) | PR |
| Q7TT36 | Adgra3 | Adhesion G protein-coupled receptor A3 | Mus musculus (Mouse) | PR |
| P59383 | Lrrn4 | Leucine-rich repeat neuronal protein 4 | Mus musculus (Mouse) | PR |
| Q9D1T0 | Lingo1 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 | Mus musculus (Mouse) | PR |
| Q8R502 | Lrrc8c | Volume-regulated anion channel subunit LRRC8C | Mus musculus (Mouse) | PR |
| Q80WG5 | Lrrc8a | Volume-regulated anion channel subunit LRRC8A | Mus musculus (Mouse) | PR |
| Q8K0S5 | Rtn4rl1 | Reticulon-4 receptor-like 1 | Mus musculus (Mouse) | PR |
| Q80TE7 | Lrrc7 | Leucine-rich repeat-containing protein 7 | Mus musculus (Mouse) | PR |
| Q5DU41 | Lrrc8b | Volume-regulated anion channel subunit LRRC8B | Mus musculus (Mouse) | PR |
| Q5RKR3 | Islr2 | Immunoglobulin superfamily containing leucine-rich repeat protein 2 | Mus musculus (Mouse) | PR |
| Q8C031 | Lrrc4c | Leucine-rich repeat-containing protein 4C | Mus musculus (Mouse) | PR |
| P70587 | Lrrc7 | Leucine-rich repeat-containing protein 7 | Rattus norvegicus (Rat) | PR |
| Q4V8G0 | Lrrc63 | Leucine-rich repeat-containing protein 63 | Rattus norvegicus (Rat) | PR |
| Q80WD0 | Rtn4rl1 | Reticulon-4 receptor-like 1 | Rattus norvegicus (Rat) | PR |
| Q9TZM3 | lrk-1 | Leucine-rich repeat serine/threonine-protein kinase 1 | Caenorhabditis elegans | SS |
| Q9SHI4 | RLP3 | Receptor-like protein 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5G5E0 | PIRL5 | Plant intracellular Ras-group-related LRR protein 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| B0JZ65 | lrwd1 | Leucine-rich repeat and WD repeat-containing protein 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q68F79 | lrrc8e | Volume-regulated anion channel subunit LRRC8E | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| B0R160 | lrwd1 | Leucine-rich repeat and WD repeat-containing protein 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKFSSLYCFL | LLLIFQTDFG | QNEETSRRQR | RKMYHRRLRK | SSLSTHRSVR | QPGIQQMKTV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TPAAKLPIIN | LDYSIEENFE | SFLSVPGVES | SYNVLPGKKG | HCLANGMIMY | NKAVWSPEPC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TTCLCLNGKV | LCDETKCHPQ | MCPQTIIPEG | ECCPVCSNTE | QREPTNLPHK | QQSPPWEEMN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RALRKEELQL | EEDEEEVKQD | ENREQKKKTF | RPGDWGRPIN | EGQSREGKAQ | RPEEEGRQAH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QHRNPARENE | EDDDEEEEDD | DDEEEDDDDE | DETIRGDTFR | MPPRLPIPAT | PRGIPSLPSM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CSLSYKTISC | ISADLTQIPP | LTAPEITSLE | LIDNSITSIP | DEAFNGLPNL | ERLDLSKNNI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TSSGIGPKAF | KFLKNLMRLN | MDGNNLVTIP | SELPSTLEEL | KINENKLQVI | DEESLSDLNQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LVTLELEGNN | LSETNVNSLA | FKPLKSLSYL | RLGRNKFRII | PQGLPASIEE | LYLENNQIEE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ITEISFNHTR | KINVIGLRYN | KIEENRIAPL | AWINQENLES | IDLSYNKLYH | VPSYLPKSLV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| HLVLIGNQIE | RIPGYVFGHM | EPGLEYLYLS | FNKLVDDGID | RVSFYGAYHS | LRELFLDHNE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LKSIPPGVQE | MKALHFLRLN | NNKIRNILPE | QICNAEEDDD | SNLQHLHLEN | NYIKTREIPS |
| 670 | |||||
| YAFSCIRSYS | SIVLKPQNIK |