P58874

PR
Gene name
OPTC (OPT)
Protein name
Opticin
Names
Oculoglycan
Species
Bos taurus (Bovine)
KEGG Pathway
bta:404034
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-51 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P58874

Entry ID Method Resolution Chain Position Source
AF-P58874-F1 Predicted AlphaFoldDB

62 variants for P58874

Variant ID(s) Position Change Description Diseaes Association Provenance
rs468224390 5 A>G No EVA
rs433702713 8 S>R No EVA
rs453720842 8 S>T No EVA
rs464183340 10 L>Q No EVA
rs433451647 11 I>T No EVA
rs476957939 14 L>M No EVA
rs472498144 18 R>M No EVA
rs441317204 19 T>I No EVA
rs434652132 21 S>A No EVA
rs443630133 25 E>D No EVA
rs462797539 27 E>G No EVA
rs468416827 29 D>V No EVA
rs447420086 30 P>S No EVA
rs464271082 38 D>G No EVA
rs432748264 48 E>D No EVA
rs456114689 49 V>G No EVA
rs470430531 58 L>I No EVA
rs455774287 59 I>R No EVA
rs435931359 59 I>V No EVA
rs472637569 60 D>N No EVA
rs451659691 63 D>V No EVA
rs443551655 66 P>H No EVA
rs443551655 66 P>R No EVA
rs436518571 96 T>S No EVA
rs379492648 97 T>M No EVA
rs134536078 111 N>H No EVA
rs378806755 139 P>S No EVA
rs383385727 143 T>M No EVA
rs714181850 160 G>E No EVA
rs452897899 167 K>N No EVA
rs431918838 179 S>A No EVA
rs452167608 180 S>P No EVA
rs476100410 186 L>V No EVA
rs444774819 204 A>V No EVA
rs41792978 207 T>A No EVA
rs475167116 209 P>R No EVA
rs440611249 210 T>A No EVA
rs460556580 221 R>G No EVA
rs460556580 221 R>W No EVA
rs436706129 223 Q>P No EVA
rs439582284 230 E>A No EVA
rs435973575 246 N>T No EVA
rs876243009 249 D>A No EVA
rs876294787 251 I>T No EVA
rs719392631 253 P>R No EVA
rs876086332 261 S>P No EVA
rs431917730 266 N>S No EVA
rs445697944 267 N>D No EVA
rs438330489 268 M>I No EVA
rs469652777 268 M>L No EVA
rs455033111 269 I>L No EVA
rs475192734 269 I>T No EVA
rs434177540 270 E>* No EVA
rs475500818 276 A>G No EVA
rs456424923 276 A>T No EVA
rs444281835 278 C>S No EVA
rs461210935 279 D>Y No EVA
rs481234300 283 H>Q No EVA
rs440867696 289 P>Q No EVA
rs459369890 296 D>E No EVA
rs460219529 305 F>S No EVA
rs378904235 308 A>V No EVA

No associated diseases with P58874

6 regional properties for P58874

Type Name Position InterPro Accession
repeat Leucine-rich repeat 147 - 202 IPR001611-1
repeat Leucine-rich repeat 237 - 258 IPR001611-2
repeat Leucine-rich repeat, typical subtype 165 - 188 IPR003591-1
repeat Leucine-rich repeat, typical subtype 189 - 211 IPR003591-2
repeat Leucine-rich repeat, typical subtype 235 - 258 IPR003591-3
repeat Leucine-rich repeat, typical subtype 259 - 279 IPR003591-4

Functions

Description
EC Number
Subcellular Localization
  • Secreted, extracellular space, extracellular matrix
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
extracellular matrix A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
collagen fibril organization Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix.

36 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3MHH9 ECM2 Extracellular matrix protein 2 Bos taurus (Bovine) PR
Q24K06 LRRC10 Leucine-rich repeat-containing protein 10 Bos taurus (Bovine) PR
Q9V780 Lap1 Protein lap1 Drosophila melanogaster (Fruit fly) PR
Q96NW7 LRRC7 Leucine-rich repeat-containing protein 7 Homo sapiens (Human) PR
Q8IWT6 LRRC8A Volume-regulated anion channel subunit LRRC8A Homo sapiens (Human) PR
Q9HCJ2 LRRC4C Leucine-rich repeat-containing protein 4C Homo sapiens (Human) PR
Q9UFC0 LRWD1 Leucine-rich repeat and WD repeat-containing protein 1 Homo sapiens (Human) PR
Q96L50 LRR1 Leucine-rich repeat protein 1 Homo sapiens (Human) PR
Q86UN2 RTN4RL1 Reticulon-4 receptor-like 1 Homo sapiens (Human) PR
Q8IWK6 ADGRA3 Adhesion G protein-coupled receptor A3 Homo sapiens (Human) PR
Q7L1W4 LRRC8D Volume-regulated anion channel subunit LRRC8D Homo sapiens (Human) PR
Q96FE5 LINGO1 Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 Homo sapiens (Human) PR
Q8TDW0 LRRC8C Volume-regulated anion channel subunit LRRC8C Homo sapiens (Human) PR
Q38SD2 LRRK1 Leucine-rich repeat serine/threonine-protein kinase 1 Homo sapiens (Human) EV
A6H694 Lrrc63 Leucine-rich repeat-containing protein 63 Mus musculus (Mouse) PR
Q9D9Q0 Lrrc69 Leucine-rich repeat-containing protein 69 Mus musculus (Mouse) PR
Q8BGI7 Lrrc39 Leucine-rich repeat-containing protein 39 Mus musculus (Mouse) PR
Q7TT36 Adgra3 Adhesion G protein-coupled receptor A3 Mus musculus (Mouse) PR
P59383 Lrrn4 Leucine-rich repeat neuronal protein 4 Mus musculus (Mouse) PR
Q9D1T0 Lingo1 Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 Mus musculus (Mouse) PR
Q8R502 Lrrc8c Volume-regulated anion channel subunit LRRC8C Mus musculus (Mouse) PR
Q80WG5 Lrrc8a Volume-regulated anion channel subunit LRRC8A Mus musculus (Mouse) PR
Q8K0S5 Rtn4rl1 Reticulon-4 receptor-like 1 Mus musculus (Mouse) PR
Q80TE7 Lrrc7 Leucine-rich repeat-containing protein 7 Mus musculus (Mouse) PR
Q5DU41 Lrrc8b Volume-regulated anion channel subunit LRRC8B Mus musculus (Mouse) PR
Q5RKR3 Islr2 Immunoglobulin superfamily containing leucine-rich repeat protein 2 Mus musculus (Mouse) PR
Q8C031 Lrrc4c Leucine-rich repeat-containing protein 4C Mus musculus (Mouse) PR
P70587 Lrrc7 Leucine-rich repeat-containing protein 7 Rattus norvegicus (Rat) PR
Q4V8G0 Lrrc63 Leucine-rich repeat-containing protein 63 Rattus norvegicus (Rat) PR
Q80WD0 Rtn4rl1 Reticulon-4 receptor-like 1 Rattus norvegicus (Rat) PR
Q9TZM3 lrk-1 Leucine-rich repeat serine/threonine-protein kinase 1 Caenorhabditis elegans SS
Q9SHI4 RLP3 Receptor-like protein 3 Arabidopsis thaliana (Mouse-ear cress) SS
Q5G5E0 PIRL5 Plant intracellular Ras-group-related LRR protein 5 Arabidopsis thaliana (Mouse-ear cress) PR
B0JZ65 lrwd1 Leucine-rich repeat and WD repeat-containing protein 1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q68F79 lrrc8e Volume-regulated anion channel subunit LRRC8E Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
B0R160 lrwd1 Leucine-rich repeat and WD repeat-containing protein 1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MKLLALLSLL ILMLQEARTA SLSEEREGDP YAILHLGDYV LSLDNYDEVI DPSNYDELID
70 80 90 100 110 120
YGDQLPQVKG TSLASLTRTR FTQSTEAART LPSNPTTARP PTLGLLAAPA NHGLPTCLIC
130 140 150 160 170 180
VCLGSSVYCD DADLENIPPL PQTTAYLYAR FNRISHIRAG DFKGLTKLKR IDLSGNSISS
190 200 210 220 230 240
IDDKALRLLP ALRDLILPEN KLVALPTLPT SIEVLDVRMN RLQSSGIQPE AFRALEKLQF
250 260 270 280 290 300
LYLADNLLDA IPPSLPLSLR SLHLQNNMIE TMQRDAFCDA EEHRHTRRPL EDIRLDGNPI
310 320
NLSLFPSAYF CLPRLPTGRF V