C0LGE4
PR
Gene name |
At1g12460 (F5O11.21, T12C24.1) |
Protein name |
Probable LRR receptor-like serine/threonine-protein kinase At1g12460 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G12460 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for C0LGE4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-C0LGE4-F1 | Predicted | AlphaFoldDB |
52 variants for C0LGE4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_1_4247715_C_A | 5 | H>N | No | 1000Genomes | |
| tmp_1_4247718_C_A | 6 | L>I | No | 1000Genomes | |
| ENSVATH11062041 | 13 | F>L | No | 1000Genomes | |
| ENSVATH11062042 | 22 | D>N | No | 1000Genomes | |
| ENSVATH04564983 | 23 | S>F | No | 1000Genomes | |
| ENSVATH00019885 | 38 | S>C | No | 1000Genomes | |
| ENSVATH04564984 | 43 | N>S | No | 1000Genomes | |
| tmp_1_4247856_G_A | 52 | G>S | No | 1000Genomes | |
| tmp_1_4247996_G_C | 98 | L>F | No | 1000Genomes | |
| tmp_1_4248019_A_T | 106 | N>I | No | 1000Genomes | |
| tmp_1_4248024_C_G | 108 | P>A | No | 1000Genomes | |
| tmp_1_4248087_G_T | 129 | G>C | No | 1000Genomes | |
| tmp_1_4248121_G_T | 140 | S>I | No | 1000Genomes | |
| tmp_1_4248128_G_T | 142 | R>S | No | 1000Genomes | |
| ENSVATH11062043 | 143 | F>L | No | 1000Genomes | |
| tmp_1_4248156_A_T | 152 | T>S | No | 1000Genomes | |
| ENSVATH04564988 | 179 | S>A | No | 1000Genomes | |
| tmp_1_4248269_C_A | 189 | N>K | No | 1000Genomes | |
| ENSVATH00019886 | 206 | P>L | No | 1000Genomes | |
| ENSVATH11062044 | 208 | I>F | No | 1000Genomes | |
| tmp_1_4248361_G_A | 220 | R>K | No | 1000Genomes | |
| tmp_1_4248447_C_G | 249 | H>D | No | 1000Genomes | |
| tmp_1_4248466_C_T | 255 | A>V | No | 1000Genomes | |
| tmp_1_4248487_T_C | 262 | I>T | No | 1000Genomes | |
| tmp_1_4248592_C_G | 297 | T>S | No | 1000Genomes | |
| ENSVATH00019887 | 329 | G>V | No | 1000Genomes | |
| ENSVATH11062115 | 357 | F>Y | No | 1000Genomes | |
| ENSVATH04564993 | 413 | R>Q | No | 1000Genomes | |
| tmp_1_4249111_C_T | 439 | S>L | No | 1000Genomes | |
| tmp_1_4249123_C_T | 443 | P>L | No | 1000Genomes | |
| ENSVATH04564994 | 449 | G>R | No | 1000Genomes | |
| ENSVATH04564994 | 449 | G>W | No | 1000Genomes | |
| ENSVATH11062118 | 455 | T>M | No | 1000Genomes | |
| ENSVATH11062118 | 455 | T>R | No | 1000Genomes | |
| tmp_1_4249161_C_T | 456 | H>Y | No | 1000Genomes | |
| ENSVATH01041610 | 491 | D>Y | No | 1000Genomes | |
| tmp_1_4249287_A_G | 498 | N>D | No | 1000Genomes | |
| ENSVATH01041611 | 510 | D>N | No | 1000Genomes | |
| ENSVATH11062119 | 520 | I>V | No | 1000Genomes | |
| ENSVATH04564996 | 543 | R>M | No | 1000Genomes | |
| tmp_1_4249495_T_G | 567 | I>R | No | 1000Genomes | |
| ENSVATH13885855 | 610 | A>T | No | 1000Genomes | |
| ENSVATH00019888 | 616 | V>I | No | 1000Genomes | |
| ENSVATH11062122 | 683 | I>F | No | 1000Genomes | |
| ENSVATH00019889 | 748 | L>I | No | 1000Genomes | |
| ENSVATH11062124 | 756 | D>G | No | 1000Genomes | |
| ENSVATH04565002 | 777 | Q>H | No | 1000Genomes | |
| tmp_1_4250140_C_T | 782 | A>V | No | 1000Genomes | |
| ENSVATH04565003 | 817 | R>T | No | 1000Genomes | |
| tmp_1_4250248_A_G | 818 | D>G | No | 1000Genomes | |
| ENSVATH04565005 | 856 | T>M | No | 1000Genomes | |
| ENSVATH01041613 | 861 | L>R | No | 1000Genomes |
No associated diseases with C0LGE4
No regional properties for C0LGE4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for C0LGE4 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P0C0K6 | EPHB6 | Ephrin type-B receptor 6 | Pan troglodytes (Chimpanzee) | SS |
| Q38SD2 | LRRK1 | Leucine-rich repeat serine/threonine-protein kinase 1 | Homo sapiens (Human) | EV |
| Q9TZM3 | lrk-1 | Leucine-rich repeat serine/threonine-protein kinase 1 | Caenorhabditis elegans | SS |
| C0LGT6 | EFR | LRR receptor-like serine/threonine-protein kinase EFR | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SHI4 | RLP3 | Receptor-like protein 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| C0LGJ1 | At1g74360 | Probable LRR receptor-like serine/threonine-protein kinase At1g74360 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6XAT2 | ERL2 | LRR receptor-like serine/threonine-protein kinase ERL2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRKVHLFLVL | VHFIYISTSR | SDSISERDIL | LQFKGSISDD | PYNSLASWVS | DGDLCNSFNG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ITCNPQGFVD | KIVLWNTSLA | GTLAPGLSNL | KFIRVLNLFG | NRFTGNLPLD | YFKLQTLWTI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NVSSNALSGP | IPEFISELSS | LRFLDLSKNG | FTGEIPVSLF | KFCDKTKFVS | LAHNNIFGSI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PASIVNCNNL | VGFDFSYNNL | KGVLPPRICD | IPVLEYISVR | NNLLSGDVSE | EIQKCQRLIL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VDLGSNLFHG | LAPFAVLTFK | NITYFNVSWN | RFGGEIGEIV | DCSESLEFLD | ASSNELTGRI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PTGVMGCKSL | KLLDLESNKL | NGSIPGSIGK | MESLSVIRLG | NNSIDGVIPR | DIGSLEFLQV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LNLHNLNLIG | EVPEDISNCR | VLLELDVSGN | DLEGKISKKL | LNLTNIKILD | LHRNRLNGSI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PPELGNLSKV | QFLDLSQNSL | SGPIPSSLGS | LNTLTHFNVS | YNNLSGVIPP | VPMIQAFGSS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| AFSNNPFLCG | DPLVTPCNSR | GAAAKSRNSD | ALSISVIIVI | IAAAVILFGV | CIVLALNLRA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RKRRKDEEIL | TVETTPLASS | IDSSGVIIGK | LVLFSKNLPS | KYEDWEAGTK | ALLDKENIIG |
| 610 | 620 | 630 | 640 | 650 | 660 |
| MGSIGSVYRA | SFEGGVSIAV | KKLETLGRIR | NQEEFEQEIG | RLGGLQHPNL | SSFQGYYFSS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| TMQLILSEFV | PNGSLYDNLH | LRIFPGTSSS | YGNTDLNWHR | RFQIALGTAK | ALSFLHNDCK |
| 730 | 740 | 750 | 760 | 770 | 780 |
| PAILHLNVKS | TNILLDERYE | AKLSDYGLEK | FLPVMDSFGL | TKKFHNAVGY | IAPELAQQSL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| RASEKCDVYS | YGVVLLELVT | GRKPVESPSE | NQVLILRDYV | RDLLETGSAS | DCFDRRLREF |
| 850 | 860 | 870 | 880 | ||
| EENELIQVMK | LGLLCTSENP | LKRPSMAEVV | QVLESIRNGF | GS |