Q9T0G7
PR
Gene name |
SUVH9 (SDG22, SET22, At4g13460, T6G15.10) |
Protein name |
Histone-lysine N-methyltransferase family member SUVH9 |
Names |
Histone H3-K9 methyltransferase 9, H3-K9-HMTase 9, Protein SET DOMAIN GROUP 22, Suppressor of variegation 3-9 homolog protein 9, Su(var)3-9 homolog protein 9 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G13460 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q9T0G7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 4NJ5 | X-ray | 240 A | A | 134-650 | PDB |
| AF-Q9T0G7-F1 | Predicted | AlphaFoldDB |
80 variants for Q9T0G7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH14170788 | 4 | S>P | No | 1000Genomes | |
| ENSVATH00498992 | 18 | L>V | No | 1000Genomes | |
| ENSVATH11640710 | 19 | I>M | No | 1000Genomes | |
| tmp_4_7826535_G_A | 24 | P>L | No | 1000Genomes | |
| ENSVATH14170787 | 25 | V>A | No | 1000Genomes | |
| ENSVATH11640709 | 31 | N>D | No | 1000Genomes | |
| ENSVATH06646064 | 32 | L>F | No | 1000Genomes | |
| ENSVATH06646063 | 33 | A>V | No | 1000Genomes | |
| ENSVATH11640708 | 37 | P>L | No | 1000Genomes | |
| tmp_4_7826497_G_A | 37 | P>S | No | 1000Genomes | |
| tmp_4_7826493_T_G | 38 | N>T | No | 1000Genomes | |
| ENSVATH06646062 | 43 | A>V | No | 1000Genomes | |
| ENSVATH00498991 | 48 | A>P | No | 1000Genomes | |
| ENSVATH00498991 | 48 | A>T | No | 1000Genomes | |
| tmp_4_7826434_A_T | 58 | F>I | No | 1000Genomes | |
| ENSVATH06646058 | 60 | S>A | No | 1000Genomes | |
| ENSVATH06646057 | 61 | D>E | No | 1000Genomes | |
| tmp_4_7826425_C_T | 61 | D>N | No | 1000Genomes | |
| tmp_4_7826424_T_A | 61 | D>V | No | 1000Genomes | |
| ENSVATH02815065 | 78 | Q>H | No | 1000Genomes | |
| ENSVATH14170786 | 79 | R>H | No | 1000Genomes | |
| ENSVATH14170785 | 80 | H>R | No | 1000Genomes | |
| ENSVATH06646054 | 82 | D>E | No | 1000Genomes | |
| tmp_4_7826339_T_A | 89 | L>F | No | 1000Genomes | |
| tmp_4_7826337_G_T | 90 | T>N | No | 1000Genomes | |
| ENSVATH00498990 | 100 | P>L | No | 1000Genomes | |
| tmp_4_7826295_G_A | 104 | P>L | No | 1000Genomes | |
| ENSVATH06646052 | 104 | P>S | No | 1000Genomes | |
| tmp_4_7826289_G_A | 106 | P>L | No | 1000Genomes | |
| ENSVATH06646051 | 110 | S>C | No | 1000Genomes | |
| ENSVATH00498989 | 112 | S>P | No | 1000Genomes | |
| ENSVATH11640707 | 119 | Q>K | No | 1000Genomes | |
| ENSVATH00498988 | 122 | R>K | No | 1000Genomes | |
| ENSVATH14170744 | 139 | E>V | No | 1000Genomes | |
| tmp_4_7826187_C_T | 140 | S>N | No | 1000Genomes | |
| tmp_4_7826170_C_G | 146 | E>Q | No | 1000Genomes | |
| tmp_4_7826114_C_T | 164 | M>I | No | 1000Genomes | |
| tmp_4_7826112_T_C | 165 | E>G | No | 1000Genomes | |
| ENSVATH06646049 | 172 | V>F | No | 1000Genomes | |
| tmp_4_7826038_T_A | 190 | M>L | No | 1000Genomes | |
| tmp_4_7826010_C_A | 199 | R>L | No | 1000Genomes | |
| tmp_4_7825946_A_C | 220 | F>L | No | 1000Genomes | |
| ENSVATH02815064 | 220 | F>V | No | 1000Genomes | |
| ENSVATH02815063 | 221 | E>D | No | 1000Genomes | |
| ENSVATH02815062 | 231 | P>S | No | 1000Genomes | |
| ENSVATH02815061 | 233 | S>A | No | 1000Genomes | |
| tmp_4_7825861_T_G | 249 | I>L | No | 1000Genomes | |
| ENSVATH11640706 | 269 | I>V | No | 1000Genomes | |
| tmp_4_7825765_C_G | 281 | G>R | No | 1000Genomes | |
| tmp_4_7825753_C_T | 285 | E>K | No | 1000Genomes | |
| ENSVATH06646047 | 312 | L>F | No | 1000Genomes | |
| tmp_4_7825576_C_T | 344 | G>S | No | 1000Genomes | |
| ENSVATH06646046 | 363 | V>L | No | 1000Genomes | |
| ENSVATH06646044 | 367 | A>G | No | 1000Genomes | |
| tmp_4_7825485_G_T | 374 | P>Q | No | 1000Genomes | |
| ENSVATH06646043 | 376 | S>T | No | 1000Genomes | |
| ENSVATH00498985 | 394 | V>D | No | 1000Genomes | |
| tmp_4_7825420_C_G | 396 | V>L | No | 1000Genomes | |
| ENSVATH06646042 | 416 | Q>R | No | 1000Genomes | |
| ENSVATH11640644 | 418 | S>L | No | 1000Genomes | |
| tmp_4_7825342_C_G | 422 | G>R | No | 1000Genomes | |
| ENSVATH11640643 | 432 | S>R | No | 1000Genomes | |
| ENSVATH06646041 | 439 | G>V | No | 1000Genomes | |
| ENSVATH00498979 | 475 | A>P | No | 1000Genomes | |
| tmp_4_7825152_C_A | 485 | R>L | No | 1000Genomes | |
| ENSVATH11640642 | 494 | R>G | No | 1000Genomes | |
| ENSVATH06646040 | 513 | L>F | No | 1000Genomes | |
| tmp_4_7825039_C_T | 523 | A>T | No | 1000Genomes | |
| ENSVATH14170740 | 527 | L>S | No | 1000Genomes | |
| ENSVATH14170741 | 527 | L>V | No | 1000Genomes | |
| ENSVATH14170738 | 576 | P>L | No | 1000Genomes | |
| ENSVATH11640640 | 576 | P>S | No | 1000Genomes | |
| tmp_4_7824852_T_C | 585 | K>R | No | 1000Genomes | |
| tmp_4_7824801_A_C | 602 | I>S | No | 1000Genomes | |
| ENSVATH06646038 | 606 | V>I | No | 1000Genomes | |
| tmp_4_7824770_A_T | 612 | S>R | No | 1000Genomes | |
| ENSVATH06646037 | 613 | L>F | No | 1000Genomes | |
| tmp_4_7824717_G_A | 630 | T>I | No | 1000Genomes | |
| ENSVATH06646033 | 640 | D>G | No | 1000Genomes | |
| tmp_4_7824672_T_G | 645 | K>T | No | 1000Genomes |
No associated diseases with Q9T0G7
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromosome, centromeric region | The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| double-stranded DNA binding | Binding to double-stranded DNA. |
| histone methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue. |
| histone-lysine N-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives. |
| zinc ion binding | Binding to a zinc ion (Zn). |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA-mediated transformation | The direct uptake and incorporation of exogenous genetic material (DNA or RNA) into a cell from its surroundings through the cell envelope. |
| gene silencing by RNA-directed DNA methylation | A small RNA-based gene silencing process in which small interfering RNAs (siRNAs) guide DNA methylation to the siRNA-generating genomic loci and other loci that are homologous to the siRNAs for de novo DNA methylation. This results in a heterochromatin assembly, a chromatin conformation that is refractory to transcription. In general this process consists of three phases: biogenesis of siRNAs, scaffold RNA production, and the formation of the guiding complex that recruits de novo DNA methyltransferases to the target loci. Transposable elements are silenced by this mechanism. |
| histone lysine methylation | The modification of a histone by addition of one or more methyl groups to a lysine residue. |
| histone methylation | The modification of histones by addition of methyl groups. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q0VD24 | SETMAR | Histone-lysine N-methyltransferase SETMAR | Bos taurus (Bovine) | PR |
| Q949T8 | ASHR3 | Histone-lysine N-methyltransferase ASHR3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C5P0 | SUVH8 | Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LVU3 | At5g47160 | YDG domain-containing protein At5g47160 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGSSHIPLDP | SLNPSPSLIP | KLEPVTESTQ | NLAFQLPNTN | PQALISSAVS | DFNEATDFSS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DYNTVAESAR | SAFAQRLQRH | DDVAVLDSLT | GAIVPVEENP | EPEPNPYSTS | DSSPSVATQR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PRPQPRSSEL | VRITDVGPES | ERQFREHVRK | TRMIYDSLRM | FLMMEEAKRN | GVGGRRARAD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GKAGKAGSMM | RDCMLWMNRD | KRIVGSIPGV | QVGDIFFFRF | ELCVMGLHGH | PQSGIDFLTG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SLSSNGEPIA | TSVIVSGGYE | DDDDQGDVIM | YTGQGGQDRL | GRQAEHQRLE | GGNLAMERSM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YYGIEVRVIR | GLKYENEVSS | RVYVYDGLFR | IVDSWFDVGK | SGFGVFKYRL | ERIEGQAEMG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SSVLKFARTL | KTNPLSVRPR | GYINFDISNG | KENVPVYLFN | DIDSDQEPLY | YEYLAQTSFP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PGLFVQQSGN | ASGCDCVNGC | GSGCLCEAKN | SGEIAYDYNG | TLIRQKPLIH | ECGSACQCPP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SCRNRVTQKG | LRNRLEVFRS | LETGWGVRSL | DVLHAGAFIC | EYAGVALTRE | QANILTMNGD |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TLVYPARFSS | ARWEDWGDLS | QVLADFERPS | YPDIPPVDFA | MDVSKMRNVA | CYISHSTDPN |
| 610 | 620 | 630 | 640 | ||
| VIVQFVLHDH | NSLMFPRVML | FAAENIPPMT | ELSLDYGVVD | DWNAKLAICN |