Q9C5P0
PR
Gene name |
SUVH8 (SDG21, SET21, At2g24740, F27A10.5) |
Protein name |
Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH8 |
Names |
Histone H3-K9 methyltransferase 8, H3-K9-HMTase 8, Protein SET DOMAIN GROUP 21, Suppressor of variegation 3-9 homolog protein 8, Su(var)3-9 homolog protein 8 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G24740 |
EC number |
2.1.1.367: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9C5P0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9C5P0-F1 | Predicted | AlphaFoldDB |
85 variants for Q9C5P0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH05581226 | 4 | T>K | No | 1000Genomes | |
| ENSVATH01886828 | 23 | L>S | No | 1000Genomes | |
| ENSVATH05581225 | 27 | E>K | No | 1000Genomes | |
| ENSVATH13381487 | 29 | S>F | No | 1000Genomes | |
| ENSVATH01886826 | 38 | A>T | No | 1000Genomes | |
| tmp_2_10531842_G_A | 39 | T>I | No | 1000Genomes | |
| ENSVATH01886825 | 40 | S>L | No | 1000Genomes | |
| ENSVATH01886824 | 42 | P>S | No | 1000Genomes | |
| ENSVATH01886823 | 44 | H>R | No | 1000Genomes | |
| ENSVATH01886820 | 68 | P>S | No | 1000Genomes | |
| ENSVATH01886818 | 71 | G>D | No | 1000Genomes | |
| ENSVATH01886819 | 71 | G>S | No | 1000Genomes | |
| ENSVATH05581222 | 72 | P>L | No | 1000Genomes | |
| ENSVATH05581223 | 72 | P>S | No | 1000Genomes | |
| ENSVATH01886817 | 90 | I>V | No | 1000Genomes | |
| ENSVATH07895298 | 91 | P>S | No | 1000Genomes | |
| ENSVATH01886815 | 110 | S>F | No | 1000Genomes | |
| ENSVATH01886814 | 120 | S>G | No | 1000Genomes | |
| ENSVATH01886813 | 121 | P>T | No | 1000Genomes | |
| tmp_2_10531572_T_C | 129 | E>G | No | 1000Genomes | |
| ENSVATH13381473 | 135 | H>Q | No | 1000Genomes | |
| ENSVATH01886809 | 139 | A>V | No | 1000Genomes | |
| ENSVATH07895286 | 166 | A>V | No | 1000Genomes | |
| ENSVATH13381471 | 168 | P>T | No | 1000Genomes | |
| ENSVATH01886804 | 175 | R>G | No | 1000Genomes | |
| ENSVATH13381470 | 188 | R>K | No | 1000Genomes | |
| ENSVATH05581218 | 192 | K>T | No | 1000Genomes | |
| ENSVATH00245573 | 201 | T>N | No | 1000Genomes | |
| ENSVATH01886799 | 207 | P>T | No | 1000Genomes | |
| ENSVATH14546214 | 217 | G>D | No | 1000Genomes | |
| ENSVATH05581215 | 220 | K>Q | No | 1000Genomes | |
| ENSVATH00245572 | 223 | K>E | No | 1000Genomes | |
| ENSVATH05581213 | 235 | D>N | No | 1000Genomes | |
| tmp_2_10531200_G_T | 253 | T>N | No | 1000Genomes | |
| tmp_2_10531032_A_C | 309 | I>S | No | 1000Genomes | |
| ENSVATH13381468 | 316 | Q>K | No | 1000Genomes | |
| ENSVATH13381465 | 336 | T>M | No | 1000Genomes | |
| ENSVATH13381466 | 336 | T>P | No | 1000Genomes | |
| ENSVATH00245569 | 366 | N>D | No | 1000Genomes | |
| tmp_2_10530838_A_T | 374 | L>M | No | 1000Genomes | |
| ENSVATH05581209 | 410 | G>R | No | 1000Genomes | |
| ENSVATH13381444 | 412 | L>F | No | 1000Genomes | |
| tmp_2_10530688_G_T | 424 | L>I | No | 1000Genomes | |
| tmp_2_10530643_A_T | 439 | F>I | No | 1000Genomes | |
| tmp_2_10530618_A_C | 447 | L>R | No | 1000Genomes | |
| tmp_2_10530613_T_G | 449 | K>Q | No | 1000Genomes | |
| ENSVATH05581206 | 449 | K>T | No | 1000Genomes | |
| tmp_2_10530609_G_A | 450 | P>L | No | 1000Genomes | |
| ENSVATH00245568 | 451 | G>D | No | 1000Genomes | |
| tmp_2_10530523_G_A | 479 | L>F | No | 1000Genomes | |
| tmp_2_10530469_C_T | 497 | V>I | No | 1000Genomes | |
| tmp_2_10530450_G_A | 503 | T>M | No | 1000Genomes | |
| ENSVATH05581203 | 507 | D>E | No | 1000Genomes | |
| ENSVATH05581204 | 507 | D>G | No | 1000Genomes | |
| tmp_2_10530426_A_G | 511 | I>T | No | 1000Genomes | |
| tmp_2_10530416_C_G | 514 | Q>H | No | 1000Genomes | |
| ENSVATH05581202 | 516 | Y>H | No | 1000Genomes | |
| ENSVATH00245567 | 520 | T>M | No | 1000Genomes | |
| ENSVATH13381442 | 524 | N>Y | No | 1000Genomes | |
| tmp_2_10530369_A_G | 530 | L>P | No | 1000Genomes | |
| tmp_2_10530367_C_A | 531 | V>F | No | 1000Genomes | |
| tmp_2_10530339_G_C | 540 | T>R | No | 1000Genomes | |
| ENSVATH14546212 | 541 | C>W | No | 1000Genomes | |
| tmp_2_10530319_C_T | 547 | G>S | No | 1000Genomes | |
| ENSVATH13381441 | 548 | Q>L | No | 1000Genomes | |
| ENSVATH00245566 | 553 | D>N | No | 1000Genomes | |
| tmp_2_10530153_C_A | 602 | R>L | No | 1000Genomes | |
| ENSVATH00245565 | 611 | T>A | No | 1000Genomes | |
| ENSVATH05581200 | 619 | E>Q | No | 1000Genomes | |
| tmp_2_10530089_A_C | 623 | D>E | No | 1000Genomes | |
| ENSVATH01886766 | 632 | R>Q | No | 1000Genomes | |
| ENSVATH01886764 | 634 | Y>N | No | 1000Genomes | |
| ENSVATH05581199 | 643 | P>S | No | 1000Genomes | |
| tmp_2_10530022_A_T | 646 | L>M | No | 1000Genomes | |
| tmp_2_10529969_T_G | 663 | Q>H | No | 1000Genomes | |
| ENSVATH05581198 | 694 | D>E | No | 1000Genomes | |
| ENSVATH00245564 | 694 | D>G | No | 1000Genomes | |
| ENSVATH14546209 | 695 | D>G | No | 1000Genomes | |
| tmp_2_10529856_T_A | 701 | Y>F | No | 1000Genomes | |
| tmp_2_10529857_A_T | 701 | Y>N | No | 1000Genomes | |
| tmp_2_10529813_C_T | 715 | M>I | No | 1000Genomes | |
| ENSVATH01886750 | 724 | I>V | No | 1000Genomes | |
| ENSVATH13381436 | 728 | E>K | No | 1000Genomes | |
| ENSVATH01886747 | 735 | V>I | No | 1000Genomes | |
| ENSVATH01886745 | 741 | K>N | No | 1000Genomes |
No associated diseases with Q9C5P0
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.367 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromosome, centromeric region | The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| double-stranded DNA binding | Binding to double-stranded DNA. |
| histone methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue. |
| histone-lysine N-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives. |
| zinc ion binding | Binding to a zinc ion (Zn). |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| histone lysine methylation | The modification of a histone by addition of one or more methyl groups to a lysine residue. |
| leaf development | The process whose specific outcome is the progression of the leaf over time, from its formation to the mature structure. |
| regulation of cell size | Any process that modulates the size of a cell. |
| regulation of gene expression, epigenetic | A process that modulates the frequency, rate or extent of gene expression through chromatin remodelling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the DNA. Once established, this regulation may be maintained over many cell divisions. It can also be heritable in the absence of the instigating signal. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q0VD24 | SETMAR | Histone-lysine N-methyltransferase SETMAR | Bos taurus (Bovine) | PR |
| Q9T0G7 | SUVH9 | Histone-lysine N-methyltransferase family member SUVH9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q949T8 | ASHR3 | Histone-lysine N-methyltransferase ASHR3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LVU3 | At5g47160 | YDG domain-containing protein At5g47160 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVSTPPTLLM | LFDDGDAGPS | TGLVHREKSD | AVNEEAHATS | VPPHAPPQTL | WLLDNFNIED |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SYDRDAGPST | GPVHRERSDA | VNEEAHATSI | PPHAPPQTLW | LLDNFNIEDS | YDRDAGPSTS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PIDREASHEV | NEDAHATSAP | PHVMVSPLQN | RRPFDQFNNQ | PYDASAGPST | GPGKRGRGRP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KGSKNGSRKP | KKPKAYDNNS | TDASAGPSSG | LGKRRCGRPK | GLKNRSRKPK | KPKADDPNSK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MVISCPDFDS | RITEAERESG | NQEIVDSILM | RFDAVRRRLC | QLNYRKDKIL | TASTNCMNLG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VRTNMTRRIG | PIPGVQVGDI | FYYWCEMCLV | GLHRNTAGGI | DSLLAKESGV | DGPAATSVVT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SGKYDNETED | LETLIYSGHG | GKPCDQVLQR | GNRALEASVR | RRNEVRVIRG | ELYNNEKVYI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YDGLYLVSDC | WQVTGKSGFK | EYRFKLLRKP | GQPPGYAIWK | LVENLRNHEL | IDPRQGFILG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DLSFGEEGLR | VPLVNEVDEE | DKTIPDDFDY | IRSQCYSGMT | NDVNVDSQSL | VQSYIHQNCT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| CILKNCGQLP | YHDNILVCRK | PLIYECGGSC | PTRMVETGLK | LHLEVFKTSN | CGWGLRSWDP |
| 610 | 620 | 630 | 640 | 650 | 660 |
| IRAGTFICEF | TGVSKTKEEV | EEDDDYLFDT | SRIYHSFRWN | YEPELLCEDA | CEQVSEDANL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| PTQVLISAKE | KGNVGRFMNH | NCWPNVFWQP | IEYDDNNGHI | YVRIGLFAMK | HIPPMTELTY |
| 730 | 740 | 750 | |||
| DYGISCVEKT | GEDEVIYKGK | KICLCGSVKC | RGSFG |