AiPD: Autoinhibited Protein Database

Gene name	SETMAR
Protein name	Histone-lysine N-methyltransferase SETMAR
Names	SET domain and mariner transposase fusion protein homolog
Species	Bos taurus (Bovine)
KEGG Pathway	bta:511299
EC number	2.1.1.357: Methyltransferases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

2-71 (Predicted disordered autoinhibitory region) PR

2-71 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q0VD24-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs453816009	2	A>E	No	EVA
rs471618573	7	V>G	No	EVA
rs437905711	11	L>S	No	EVA
rs469086474	13	G>A	No	EVA
rs449230925	20	G>V	No	EVA
rs435569342	21	L>I	No	EVA
rs466900695	21	L>P	No	EVA
rs446941713	22	E>Q	No	EVA
rs458385631	24	L>R	No	EVA
rs451112701	25	P>H	No	EVA
rs482550980	32	G>R	No	EVA
rs442316472	34	E>D	No	EVA
rs460060264	39	Q>H	No	EVA
rs473833237	39	Q>K	No	EVA
rs448098726	50	A>E	No	EVA
rs133874747	52	A>T	No	EVA
rs445841352	53	D>E	No	EVA
rs801039369	78	R>H	No	EVA
rs443516218	88	C>*	No	EVA
rs463668535	88	C>S	No	EVA
rs517089473	92	I>T	No	EVA
rs135249241	99	T>A	No	EVA
rs876269878	119	V>G	No	EVA
rs876162327	122	W>G	No	EVA
rs441332037	159	V>A	No	EVA
rs447508360	227	M>I	No	EVA
rs382744157	300	T>M	No	EVA

Type	Name	Position	InterPro Accession
domain	SET domain	126 - 256	IPR001214
domain	Post-SET domain	270 - 286	IPR003616
domain	Pre-SET domain	14 - 123	IPR007728

		Description
EC Number	2.1.1.357	Methyltransferases
Subcellular Localization	Nucleus Chromosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
chromosome	A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
double-stranded DNA binding	Binding to double-stranded DNA.
histone methyltransferase activity	Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue.
histone methyltransferase activity (H3-K36 specific)	Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group onto lysine at position 36 of the histone H3 protein.
histone methyltransferase activity (H3-K4 specific)	Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of a methyl group onto lysine at position 4 of the histone H3 protein.
zinc ion binding	Binding to a zinc ion (Zn).

Name	Definition
chromatin organization	The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
histone H3-K36 methylation	The modification of histone H3 by addition of one or more methyl groups to lysine at position 36 of the histone.
histone H3-K4 methylation	The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone.
histone methylation	The modification of histones by addition of methyl groups.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9C5P0	SUVH8	Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH8	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9T0G7	SUVH9	Histone-lysine N-methyltransferase family member SUVH9	Arabidopsis thaliana (Mouse-ear cress)	PR