Q9SU64
PR
Gene name |
CNGC16 (At3g48010, T17F15.120) |
Protein name |
Probable cyclic nucleotide-gated ion channel 16 |
Names |
Cyclic nucleotide- and calmodulin-regulated ion channel 16 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G48010 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9SU64
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9SU64-F1 | Predicted | AlphaFoldDB |
68 variants for Q9SU64
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH12626686 | 6 | L>F | No | 1000Genomes | |
| tmp_3_17724012_A_C,G | 6 | L>P | No | 1000Genomes | |
| tmp_3_17724012_A_C,G | 6 | L>R | No | 1000Genomes | |
| tmp_3_17724007_T_C | 8 | T>A | No | 1000Genomes | |
| ENSVATH12626685 | 15 | F>S | No | 1000Genomes | |
| ENSVATH06265611 | 22 | R>H | No | 1000Genomes | |
| ENSVATH06265611 | 22 | R>L | No | 1000Genomes | |
| ENSVATH02466304 | 31 | Q>H | No | 1000Genomes | |
| ENSVATH00406938 | 39 | K>E | No | 1000Genomes | |
| tmp_3_17723887_C_T | 48 | G>S | No | 1000Genomes | |
| tmp_3_17723862_T_G | 56 | N>T | No | 1000Genomes | |
| ENSVATH12626634 | 91 | R>H | No | 1000Genomes | |
| ENSVATH00406936 | 98 | C>F | No | 1000Genomes | |
| tmp_3_17723725_G_C | 102 | L>V | No | 1000Genomes | |
| ENSVATH06265609 | 120 | V>E | No | 1000Genomes | |
| ENSVATH06265608 | 145 | K>R | No | 1000Genomes | |
| tmp_3_17723347_A_T | 173 | F>Y | No | 1000Genomes | |
| tmp_3_17723309_T_C | 186 | I>V | No | 1000Genomes | |
| tmp_3_17723207_C_T | 220 | A>T | No | 1000Genomes | |
| tmp_3_17723084_C_T | 237 | V>I | No | 1000Genomes | |
| tmp_3_17723068_G_A | 242 | S>L | No | 1000Genomes | |
| ENSVATH12626629 | 251 | R>K | No | 1000Genomes | |
| ENSVATH00406931 | 277 | H>Q | No | 1000Genomes | |
| tmp_3_17722958_G_A | 279 | P>S | No | 1000Genomes | |
| ENSVATH00406930 | 298 | N>K | No | 1000Genomes | |
| ENSVATH12626626 | 353 | T>S | No | 1000Genomes | |
| tmp_3_17722615_G_C | 362 | A>G | No | 1000Genomes | |
| tmp_3_17722580_C_T | 374 | V>I | No | 1000Genomes | |
| ENSVATH02466254 | 413 | R>W | No | 1000Genomes | |
| ENSVATH12626593 | 433 | R>Q | No | 1000Genomes | |
| ENSVATH12626592 | 434 | A>D | No | 1000Genomes | |
| tmp_3_17722321_G_A | 436 | P>S | No | 1000Genomes | |
| tmp_3_17722306_G_A | 441 | R>C | No | 1000Genomes | |
| ENSVATH12626590 | 481 | D>E | No | 1000Genomes | |
| tmp_3_17722067_T_G | 492 | N>T | No | 1000Genomes | |
| tmp_3_17722058_A_T | 495 | L>H | No | 1000Genomes | |
| tmp_3_17722053_T_C | 497 | I>V | No | 1000Genomes | |
| ENSVATH12626588 | 499 | R>G | No | 1000Genomes | |
| tmp_3_17722019_T_C | 508 | D>G | No | 1000Genomes | |
| tmp_3_17721924_T_G | 540 | N>H | No | 1000Genomes | |
| tmp_3_17721916_A_T | 542 | N>K | No | 1000Genomes | |
| ENSVATH12626586 | 554 | S>C | No | 1000Genomes | |
| tmp_3_17721851_T_A | 564 | E>V | No | 1000Genomes | |
| tmp_3_17721804_T_C | 580 | K>E | No | 1000Genomes | |
| ENSVATH06265595 | 593 | R>K | No | 1000Genomes | |
| ENSVATH06265594 | 613 | A>P | No | 1000Genomes | |
| tmp_3_17721598_G_A | 619 | Q>* | No | 1000Genomes | |
| ENSVATH00406920 | 620 | E>D | No | 1000Genomes | |
| tmp_3_17721595_C_T | 620 | E>K | No | 1000Genomes | |
| ENSVATH00406919 | 631 | G>E | No | 1000Genomes | |
| ENSVATH00406918 | 635 | F>Y | No | 1000Genomes | |
| ENSVATH00406917 | 639 | M>I | No | 1000Genomes | |
| ENSVATH00406916 | 643 | N>S | No | 1000Genomes | |
| tmp_3_17721521_A_T | 644 | N>K | No | 1000Genomes | |
| ENSVATH02466236 | 652 | S>N | No | 1000Genomes | |
| tmp_3_17721492_T_C | 654 | N>S | No | 1000Genomes | |
| ENSVATH14397734 | 658 | S>C | No | 1000Genomes | |
| tmp_3_17721480_C_T | 658 | S>N | No | 1000Genomes | |
| tmp_3_17721474_G_C | 660 | T>R | No | 1000Genomes | |
| tmp_3_17721440_C_A | 671 | K>N | No | 1000Genomes | |
| ENSVATH02466232 | 673 | G>C | No | 1000Genomes | |
| ENSVATH14397733 | 677 | N>S | No | 1000Genomes | |
| tmp_3_17721411_G_A | 681 | S>F | No | 1000Genomes | |
| ENSVATH06265593 | 684 | I>N | No | 1000Genomes | |
| ENSVATH12626551 | 689 | P>L | No | 1000Genomes | |
| ENSVATH12626552 | 689 | P>S | No | 1000Genomes | |
| ENSVATH12626550 | 696 | M>I | No | 1000Genomes | |
| tmp_3_17721357_G_T | 699 | P>Q | No | 1000Genomes |
No associated diseases with Q9SU64
No regional properties for Q9SU64
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9SU64 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| cAMP binding | Binding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate). |
| cGMP binding | Binding to cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate). |
| ion channel activity | Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size). |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
31 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q03041 | CNGA2 | Cyclic nucleotide-gated olfactory channel | Bos taurus (Bovine) | PR |
| Q00194 | CNGA1 | cGMP-gated cation channel alpha-1 | Bos taurus (Bovine) | PR |
| Q29441 | CNGA3 | Cyclic nucleotide-gated cation channel alpha-3 | Bos taurus (Bovine) | PR |
| Q90980 | Cyclic nucleotide-gated channel rod photoreceptor subunit alpha | Gallus gallus (Chicken) | PR | |
| Q28279 | CNGA1 | cGMP-gated cation channel alpha-1 | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| Q9UL51 | HCN2 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | Homo sapiens (Human) | SS |
| Q9Y3Q4 | HCN4 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | Homo sapiens (Human) | EV |
| O60741 | HCN1 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | Homo sapiens (Human) | SS |
| Q9P1Z3 | HCN3 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 | Homo sapiens (Human) | SS |
| Q16281 | CNGA3 | Cyclic nucleotide-gated cation channel alpha-3 | Homo sapiens (Human) | PR |
| P29973 | CNGA1 | cGMP-gated cation channel alpha-1 | Homo sapiens (Human) | PR |
| Q16280 | CNGA2 | Cyclic nucleotide-gated olfactory channel | Homo sapiens (Human) | PR |
| O88704 | Hcn1 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | Mus musculus (Mouse) | SS |
| O88705 | Hcn3 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 | Mus musculus (Mouse) | SS |
| O70507 | Hcn4 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | Mus musculus (Mouse) | SS |
| O88703 | Hcn2 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | Mus musculus (Mouse) | EV |
| Q9JJZ8 | Cnga3 | Cyclic nucleotide-gated cation channel alpha-3 | Mus musculus (Mouse) | PR |
| P29974 | Cnga1 | cGMP-gated cation channel alpha-1 | Mus musculus (Mouse) | PR |
| Q62398 | Cnga2 | Cyclic nucleotide-gated olfactory channel | Mus musculus (Mouse) | PR |
| Q9JKA9 | Hcn2 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | Rattus norvegicus (Rat) | SS |
| Q9JKA7 | Hcn4 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | Rattus norvegicus (Rat) | SS |
| Q9JKB0 | Hcn1 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | Rattus norvegicus (Rat) | SS |
| Q9JKA8 | Hcn3 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 | Rattus norvegicus (Rat) | SS |
| Q62927 | Cnga1 | cGMP-gated cation channel alpha-1 | Rattus norvegicus (Rat) | PR |
| Q00195 | Cnga2 | Cyclic nucleotide-gated olfactory channel | Rattus norvegicus (Rat) | PR |
| A2ZX97 | Os01g0718700 | Potassium channel KAT6 | Oryza sativa subsp japonica (Rice) | PR |
| Q6K3T2 | Os02g0245800 | Potassium channel KAT1 | Oryza sativa subsp japonica (Rice) | PR |
| P92960 | ATHB-4 | Potassium channel KAT3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q39128 | KAT1 | Potassium channel KAT1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LDR2 | CNGC19 | Putative cyclic nucleotide-gated ion channel 19 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SKD7 | CNGC3 | Probable cyclic nucleotide-gated ion channel 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSNLHLYTSA | RFRNFPTTFS | LRHHHNDPNN | QRRRSIFSKL | RDKTLDPGGD | LITRWNHIFL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ITCLLALFLD | PLYFYLPIVQ | AGTACMSIDV | RFGIFVTCFR | NLADLSFLIH | ILLKFKTAFV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SKSSRVFGRG | ELVMDRREIA | IRYLKSEFVI | DLAATLPLPQ | IMIWFVIPNA | GEFRYAAHQN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HTLSLIVLIQ | YVPRFLVMLP | LNRRIIKATG | VAAKTAWSGA | AYNLILYLLV | SHVLGSVWYV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LSIQRQHECW | RRECIKEMNA | THSPSCSLLF | LDCGSLHDPG | RQAWMRITRV | LSNCDARNDD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DQHFQFGMFG | DAFTNDVTSS | PFFDKYFYCL | WWGLRNLSSY | GQSLAASTLS | SETIFSCFIC |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VAGLVFFSHL | IGNVQNYLQS | TTARLDEWRV | RRRDTEEWMR | HRQLPDELQE | RVRRFVQYKW |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LTTRGVDEEA | ILRALPLDLR | RQIQRHLCLA | LVRRVPFFAQ | MDDQLLDAIC | ERLVPSLNTK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DTYVIREGDP | VNEMLFIIRG | QMESSTTDGG | RSGFFNSITL | RPGDFCGEEL | LTWALVPNIN |
| 550 | 560 | 570 | 580 | 590 | 600 |
| HNLPLSTRTV | RTLSEVEAFA | LRAEDLKFVA | NQFRRLHSKK | LQHAFRYYSH | QWRAWGTCFI |
| 610 | 620 | 630 | 640 | 650 | 660 |
| QAAWRRYMKR | KLAMELARQE | EEDDYFYDDD | GDYQFEEDMP | ESNNNNGDEN | SSNNQNLSAT |
| 670 | 680 | 690 | 700 | ||
| ILASKFAANT | KRGVLGNQRG | STRIDPDHPT | LKMPKMFKPE | DPGFF |