Q03041
Gene name |
CNGA2 (CNCG2) |
Protein name |
Cyclic nucleotide-gated olfactory channel |
Names |
Cyclic nucleotide-gated cation channel 2, Cyclic nucleotide-gated channel alpha-2, CNG channel alpha-2, CNG-2, CNG2 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:407172 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q03041
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1SY9 | NMR | - | B | 60-85 | PDB |
| AF-Q03041-F1 | Predicted | AlphaFoldDB |
No variants for Q03041
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q03041 | |||||
No associated diseases with Q03041
5 regional properties for Q03041
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cyclic nucleotide-binding domain | 454 - 578 | IPR000595 |
| domain | Ion transport domain | 142 - 381 | IPR005821 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 481 - 497 | IPR018488-1 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 519 - 542 | IPR018488-2 |
| domain | Cyclic nucleotide-gated channel, C-terminal leucine zipper domain | 570 - 638 | IPR032406 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| cAMP binding | Binding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate). |
| ion channel activity | Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| response to stimulus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. |
| sensory perception of smell | The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q00194 | CNGA1 | cGMP-gated cation channel alpha-1 | Bos taurus (Bovine) | PR |
| Q29441 | CNGA3 | Cyclic nucleotide-gated cation channel alpha-3 | Bos taurus (Bovine) | PR |
| Q90980 | Cyclic nucleotide-gated channel rod photoreceptor subunit alpha | Gallus gallus (Chicken) | PR | |
| Q90805 | Cyclic nucleotide-gated channel cone photoreceptor subunit alpha | Gallus gallus (Chicken) | PR | |
| Q16281 | CNGA3 | Cyclic nucleotide-gated cation channel alpha-3 | Homo sapiens (Human) | PR |
| P29973 | CNGA1 | cGMP-gated cation channel alpha-1 | Homo sapiens (Human) | PR |
| Q16280 | CNGA2 | Cyclic nucleotide-gated olfactory channel | Homo sapiens (Human) | PR |
| Q9JJZ8 | Cnga3 | Cyclic nucleotide-gated cation channel alpha-3 | Mus musculus (Mouse) | PR |
| P29974 | Cnga1 | cGMP-gated cation channel alpha-1 | Mus musculus (Mouse) | PR |
| Q62398 | Cnga2 | Cyclic nucleotide-gated olfactory channel | Mus musculus (Mouse) | PR |
| Q62927 | Cnga1 | cGMP-gated cation channel alpha-1 | Rattus norvegicus (Rat) | PR |
| Q00195 | Cnga2 | Cyclic nucleotide-gated olfactory channel | Rattus norvegicus (Rat) | PR |
| Q9SKD7 | CNGC3 | Probable cyclic nucleotide-gated ion channel 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SU64 | CNGC16 | Probable cyclic nucleotide-gated ion channel 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LDR2 | CNGC19 | Putative cyclic nucleotide-gated ion channel 19 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTEKANGVKS | SPANNHNHHA | PPAIKASGKD | DHRASSRPQS | AAADDTSSEL | QQLAEMDAPQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QRRGGFRRIA | RLVGVLREWA | YRNFREEEPR | PDSFLERFRG | PELHTVTTQQ | GDGKGDKDGE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GKGTKKKFEL | FVLDPAGDWY | YRWLFLIALP | VLYNWCLLVA | RACFSDLQKG | YYIVWLVLDY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VSDVVYIADL | FIRLRTGFLE | QGLLVKDTKK | LRDNYIHTMQ | FKLDVASIIP | TDLIYFAVGI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HNPEVRFNRL | LHFARMFEFF | DRTETRTSYP | NIFRISNLIL | YILIIIHWNA | CIYYAISKSI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GFGVDTWVYP | NITDPEYGYL | SREYIYCLYW | STLTLTTIGE | TPPPVKDEEY | LFVIFDFLIG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VLIFATIVGN | VGSMISNMNA | TRAEFQAKID | AVKHYMQFRK | VSKEMEAKVI | RWFDYLWTNK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KSVDEREVLK | NLPAKLRAEI | AINVHLSTLK | KVRIFQDCEA | GLLVELVLKL | RPQVFSPGDY |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ICRKGDIGKE | MYIIKEGKLA | VVADDGVTQY | ALLSAGSCFG | EISILNIKGS | KMGNRRTANI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RSLGYSDLFC | LSKDDLMEAV | TEYPDAKRVL | EERGREILMK | EGLLDENEVA | ASMEVDVQEK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LEQLETNMDT | LYTRFARLLA | EYTGAQQKLK | QRITVLETKM | KQNNEDDSLS | DGMNSPEPPA |
| EKP |