Q9SKD7

PR
Gene name
CNGC3 (At2g46430, F11C10.12)
Protein name
Probable cyclic nucleotide-gated ion channel 3
Names
AtCNGC3, Cyclic nucleotide- and calmodulin-regulated ion channel 3
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT2G46430
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-87 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9SKD7

Entry ID Method Resolution Chain Position Source
AF-Q9SKD7-F1 Predicted AlphaFoldDB

69 variants for Q9SKD7

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH00277056 24 T>N No 1000Genomes
tmp_2_19058627_C_T 27 S>L No 1000Genomes
tmp_2_19058629_G_A 28 V>I No 1000Genomes
ENSVATH13655029 36 R>S No 1000Genomes
ENSVATH05728075 39 F>L No 1000Genomes
ENSVATH01993613 41 K>M No 1000Genomes
ENSVATH01993614 48 T>N No 1000Genomes
ENSVATH01993614 48 T>S No 1000Genomes
ENSVATH05728076 62 E>K No 1000Genomes
ENSVATH01993615 65 K>N No 1000Genomes
ENSVATH05728077 66 K>N No 1000Genomes
ENSVATH05728078 69 I>M No 1000Genomes
tmp_2_19058854_T_TA 103 Y>* No 1000Genomes
tmp_2_19058890_A_C 115 N>H No 1000Genomes
tmp_2_19058912_C_G 122 T>R No 1000Genomes
ENSVATH05728079 134 F>I No 1000Genomes
ENSVATH00277058 148 I>S No 1000Genomes
ENSVATH00277058 148 I>T No 1000Genomes
ENSVATH05728080 153 S>N No 1000Genomes
tmp_2_19059029_A_G 161 N>S No 1000Genomes
ENSVATH05728082 187 P>H No 1000Genomes
tmp_2_19059213_A_G 194 I>V No 1000Genomes
tmp_2_19059223_G_A 197 R>K No 1000Genomes
ENSVATH05728086 202 A>T No 1000Genomes
ENSVATH14620796 227 P>S No 1000Genomes
tmp_2_19059340_C_T 236 S>F No 1000Genomes
ENSVATH13655067 260 V>D No 1000Genomes
ENSVATH13655068 262 G>W No 1000Genomes
tmp_2_19059561_G_A 278 R>H No 1000Genomes
ENSVATH01993627 286 N>D No 1000Genomes
ENSVATH01993628 288 T>S No 1000Genomes
ENSVATH01993629 290 A>E No 1000Genomes
ENSVATH05728091 291 Y>* No 1000Genomes
ENSVATH01993630 291 Y>N No 1000Genomes
ENSVATH00277061 299 E>K No 1000Genomes
ENSVATH13655070 320 S>W No 1000Genomes
ENSVATH00277063 368 A>S No 1000Genomes
ENSVATH14620798 415 A>V No 1000Genomes
ENSVATH00277065 431 R>C No 1000Genomes
ENSVATH01993644 449 E>D No 1000Genomes
ENSVATH01993645 452 L>V No 1000Genomes
ENSVATH13655087 459 L>F No 1000Genomes
ENSVATH01993648 489 L>V No 1000Genomes
ENSVATH01993650 510 P>A No 1000Genomes
ENSVATH01993651 511 V>E No 1000Genomes
ENSVATH05728096 525 T>S No 1000Genomes
ENSVATH14620800 528 Y>S No 1000Genomes
ENSVATH01993655 531 R>K No 1000Genomes
ENSVATH00277068 541 V>A No 1000Genomes
ENSVATH01993668 571 L>S No 1000Genomes
ENSVATH01993668 571 L>W No 1000Genomes
ENSVATH01993669 578 L>V No 1000Genomes
ENSVATH05728097 586 F>C No 1000Genomes
ENSVATH01993670 586 F>L No 1000Genomes
ENSVATH01993674 603 F>L No 1000Genomes
ENSVATH01993690 608 V>G No 1000Genomes
ENSVATH01993689 608 V>M No 1000Genomes
tmp_2_19061032_G_A 627 R>K No 1000Genomes
tmp_2_19061056_G_A 635 R>H No 1000Genomes
ENSVATH05728102 636 E>Q No 1000Genomes
ENSVATH01993693 643 N>D No 1000Genomes
ENSVATH05728103 643 N>S No 1000Genomes
ENSVATH01993696 654 K>Q No 1000Genomes
ENSVATH01993701 659 A>V No 1000Genomes
ENSVATH01993702 662 Y>N No 1000Genomes
ENSVATH01993710 688 M>I No 1000Genomes
ENSVATH00277070 690 T>S No 1000Genomes
ENSVATH14620825 700 E>K No 1000Genomes
ENSVATH05728104 706 T>A No 1000Genomes

No associated diseases with Q9SKD7

5 regional properties for Q9SKD7

Type Name Position InterPro Accession
domain VHS domain 8 - 147 IPR002014
domain GAT domain 171 - 300 IPR004152
domain Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain 507 - 631 IPR008152
domain Gamma-adaptin ear (GAE) domain 510 - 631 IPR008153
domain N-terminal extension of GAT domain 169 - 207 IPR041198

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
calmodulin binding Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
cAMP binding Binding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate).
cGMP binding Binding to cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate).
ion channel activity Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size).

No GO annotations of biological process

Name Definition
No GO annotations for biological process

31 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q03041 CNGA2 Cyclic nucleotide-gated olfactory channel Bos taurus (Bovine) PR
Q00194 CNGA1 cGMP-gated cation channel alpha-1 Bos taurus (Bovine) PR
Q29441 CNGA3 Cyclic nucleotide-gated cation channel alpha-3 Bos taurus (Bovine) PR
Q90980 Cyclic nucleotide-gated channel rod photoreceptor subunit alpha Gallus gallus (Chicken) PR
Q28279 CNGA1 cGMP-gated cation channel alpha-1 Canis lupus familiaris (Dog) (Canis familiaris) PR
Q9UL51 HCN2 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 Homo sapiens (Human) SS
Q9Y3Q4 HCN4 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Homo sapiens (Human) EV
O60741 HCN1 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 Homo sapiens (Human) SS
Q9P1Z3 HCN3 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 Homo sapiens (Human) SS
Q16281 CNGA3 Cyclic nucleotide-gated cation channel alpha-3 Homo sapiens (Human) PR
P29973 CNGA1 cGMP-gated cation channel alpha-1 Homo sapiens (Human) PR
Q16280 CNGA2 Cyclic nucleotide-gated olfactory channel Homo sapiens (Human) PR
O88704 Hcn1 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 Mus musculus (Mouse) SS
O88705 Hcn3 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 Mus musculus (Mouse) SS
O70507 Hcn4 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Mus musculus (Mouse) SS
O88703 Hcn2 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 Mus musculus (Mouse) EV
Q9JJZ8 Cnga3 Cyclic nucleotide-gated cation channel alpha-3 Mus musculus (Mouse) PR
P29974 Cnga1 cGMP-gated cation channel alpha-1 Mus musculus (Mouse) PR
Q62398 Cnga2 Cyclic nucleotide-gated olfactory channel Mus musculus (Mouse) PR
Q9JKA9 Hcn2 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 Rattus norvegicus (Rat) SS
Q9JKA7 Hcn4 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Rattus norvegicus (Rat) SS
Q9JKB0 Hcn1 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 Rattus norvegicus (Rat) SS
Q9JKA8 Hcn3 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 Rattus norvegicus (Rat) SS
Q62927 Cnga1 cGMP-gated cation channel alpha-1 Rattus norvegicus (Rat) PR
Q00195 Cnga2 Cyclic nucleotide-gated olfactory channel Rattus norvegicus (Rat) PR
A2ZX97 Os01g0718700 Potassium channel KAT6 Oryza sativa subsp japonica (Rice) PR
Q6K3T2 Os02g0245800 Potassium channel KAT1 Oryza sativa subsp japonica (Rice) PR
P92960 ATHB-4 Potassium channel KAT3 Arabidopsis thaliana (Mouse-ear cress) PR
Q39128 KAT1 Potassium channel KAT1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LDR2 CNGC19 Putative cyclic nucleotide-gated ion channel 19 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SU64 CNGC16 Probable cyclic nucleotide-gated ion channel 16 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MMNPQRNKFV RFNGNDDEFS TKTTRPSVSS VMKTVRRSFE KGSEKIRTFK RPLSVHSNKN
70 80 90 100 110 120
KENNKKKKIL RVMNPNDSYL QSWNKIFLLL SVVALAFDPL FFYIPYVKPE RFCLNLDKKL
130 140 150 160 170 180
QTIACVFRTF IDAFYVVHML FQFHTGFITP SSSGFGRGEL NEKHKDIALR YLGSYFLIDL
190 200 210 220 230 240
LSILPIPQVV VLAIVPRMRR PASLVAKELL KWVIFCQYVP RIARIYPLFK EVTRTSGLVT
250 260 270 280 290 300
ETAWAGAALN LFLYMLASHV FGSFWYLISI ERKDRCWREA CAKIQNCTHA YLYCSPTGED
310 320 330 340 350 360
NRLFLNGSCP LIDPEEITNS TVFNFGIFAD ALQSGVVESR DFPKKFFYCF WWGLRNLSAL
370 380 390 400 410 420
GQNLKTSAFE GEIIFAIVIC ISGLVLFALL IGNMQKYLQS TTVRVEEMRV KRRDAEQWMS
430 440 450 460 470 480
HRMLPDDLRK RIRKYEQYKW QETKGVEEEA LLSSLPKDLR KDIKRHLCLK LLKKVPWFQA
490 500 510 520 530 540
MDDRLLDALC ARLKTVLYTE KSYIVREGEP VEDMLFIMRG NLISTTTYGG RTGFFNSVDL
550 560 570 580 590 600
VAGDFCGDLL TWALDPLSSQ FPISSRTVQA LTEVEGFLLS ADDLKFVATQ YRRLHSKQLR
610 620 630 640 650 660
HMFRFYSVQW QTWAACFIQA AWKRHCRRKL SKALREEEGK LHNTLQNDDS GGNKLNLGAA
670 680 690 700
IYASRFASHA LRNLRANAAA RNSRFPHMLT LLPQKPADPE FPMDET