Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A2ZX97
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A2ZX97-F1 | Predicted | AlphaFoldDB |
No variants for A2ZX97
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A2ZX97 | |||||
No associated diseases with A2ZX97
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| voltage-gated potassium channel activity | Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of ion transmembrane transport | Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. |
18 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O60741 | HCN1 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | Homo sapiens (Human) | SS |
| Q9P1Z3 | HCN3 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 | Homo sapiens (Human) | SS |
| Q9UL51 | HCN2 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | Homo sapiens (Human) | SS |
| Q9Y3Q4 | HCN4 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | Homo sapiens (Human) | EV |
| O88704 | Hcn1 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | Mus musculus (Mouse) | SS |
| O88705 | Hcn3 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 | Mus musculus (Mouse) | SS |
| O70507 | Hcn4 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | Mus musculus (Mouse) | SS |
| O88703 | Hcn2 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | Mus musculus (Mouse) | EV |
| Q9JKA9 | Hcn2 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | Rattus norvegicus (Rat) | SS |
| Q9JKA7 | Hcn4 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | Rattus norvegicus (Rat) | SS |
| Q9JKB0 | Hcn1 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | Rattus norvegicus (Rat) | SS |
| Q9JKA8 | Hcn3 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 | Rattus norvegicus (Rat) | SS |
| Q6K3T2 | Os02g0245800 | Potassium channel KAT1 | Oryza sativa subsp japonica (Rice) | PR |
| Q9SKD7 | CNGC3 | Probable cyclic nucleotide-gated ion channel 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LDR2 | CNGC19 | Putative cyclic nucleotide-gated ion channel 19 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SU64 | CNGC16 | Probable cyclic nucleotide-gated ion channel 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q39128 | KAT1 | Potassium channel KAT1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P92960 | ATHB-4 | Potassium channel KAT3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAASRSELLR | PAFGEPSPSL | GPFVVNPHTC | SYRWWQKFLI | VLVLYTAWAS | PFELAMEKSA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SAALAVTELV | VDAFFAVDIA | VSFFVAYRDA | STGLLVTDRK | KIATRHLARP | CLALDVASTI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PLQMIYRIVS | GKRQALYGLL | NLLRLWRLRR | VSKLFARLEK | DIRFSYLWTR | LIKLLYVTLF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AVHFASCIYL | WMAFHHKAKE | LTWIGSQFHG | FEDRSVWFCY | TCAVYWSITT | LATVGYGDLH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AANTGEMLFS | IAFMLFNMGL | TSYIIGNITN | LVVHETTNTF | KMRDMVQRTS | VFGRTNRLPV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AMREQMMESL | QLRFRAEEQL | QQEMLSELPK | AVRSGIAQHM | FRGAVQSCYL | FQGVSDKLVL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PLVAEMKAES | FPPKADIILE | NEASTDCYII | VSGEVEVLTT | LEDGTEKQVM | RIGPRGMAGE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IGVMFNIPQP | FTIRSRKLTQ | LVRISHSHMV | STIRPNTADG | VVVFSNFVLY | LESLKVKAKE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TAFVRDHLRN | GYSTVLGSAT | MFDVDESKES | AHKMLPCKEP | KRVSIHEHLL | NGTGTALNGS |
| 550 | 560 | 570 | 580 | 590 | |
| SGKLVILPDS | MQDLMKLSEK | KFGKAARGIL | TVGGAEVEDI | EVIRDGDHLF | FSW |