Q9SLD2
PR
Gene name |
DGAT1 |
Protein name |
Diacylglycerol O-acyltransferase 1 |
Names |
AtDGAT1, Protein TRIACYLGLYCEROL 1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G19450 |
EC number |
2.3.1.20: Transferring groups other than amino-acyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9SLD2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9SLD2-F1 | Predicted | AlphaFoldDB |
23 variants for Q9SLD2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_2_8426454_G_T | 7 | A>S | No | 1000Genomes | |
| tmp_2_8426470_T_C | 12 | V>A | No | 1000Genomes | |
| ENSVATH00238741 | 31 | S>T | No | 1000Genomes | |
| ENSVATH13282214 | 43 | G>A | No | 1000Genomes | |
| tmp_2_8426562_G_C | 43 | G>R | No | 1000Genomes | |
| tmp_2_8426578_C_T | 48 | S>F | No | 1000Genomes | |
| ENSVATH05533963 | 49 | P>S | No | 1000Genomes | |
| tmp_2_8426637_A_G | 68 | N>D | No | 1000Genomes | |
| tmp_2_8426667_G_C | 78 | A>P | No | 1000Genomes | |
| ENSVATH13282226 | 84 | G>D | No | 1000Genomes | |
| ENSVATH13282227 | 88 | N>H | No | 1000Genomes | |
| ENSVATH13282228 | 88 | N>I | No | 1000Genomes | |
| tmp_2_8426728_G_A | 98 | R>K | No | 1000Genomes | |
| ENSVATH05533966 | 101 | A>V | No | 1000Genomes | |
| tmp_2_8426949_A_G | 144 | I>V | No | 1000Genomes | |
| tmp_2_8427292_A_T | 194 | T>S | No | 1000Genomes | |
| ENSVATH05533971 | 201 | Q>K | No | 1000Genomes | |
| tmp_2_8427440_T_A | 211 | F>I | No | 1000Genomes | |
| ENSVATH14520976 | 217 | T>I | No | 1000Genomes | |
| tmp_2_8427470_G_A | 221 | V>I | No | 1000Genomes | |
| tmp_2_8427689_A_T | 267 | N>Y | No | 1000Genomes | |
| tmp_2_8428869_A_G | 436 | I>V | No | 1000Genomes | |
| tmp_2_8429031_C_A | 449 | L>I | No | 1000Genomes |
No associated diseases with Q9SLD2
No regional properties for Q9SLD2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9SLD2 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.1.20 | Transferring groups other than amino-acyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloroplast envelope | The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space. |
| chloroplast membrane | Either of the lipid bilayers that surround a chloroplast and form the chloroplast envelope. |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| lipid droplet | An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| diacylglycerol O-acyltransferase activity | Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol. |
| O-acyltransferase activity | Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule. |
12 GO annotations of biological process
| Name | Definition |
|---|---|
| aging | A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700). |
| carbohydrate metabolic process | The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. |
| embryo development ending in seed dormancy | The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. An example of this process is found in Arabidopsis thaliana. |
| glycerol metabolic process | The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. |
| positive regulation of seed germination | Any process that activates or increase the rate of seed germination. |
| regulation of embryonic development | Any process that modulates the frequency, rate or extent of embryonic development. |
| regulation of seed germination | Any process that modulates the frequency, rate or extent of seed germination. |
| response to abscisic acid | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus. |
| response to cold | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. |
| response to glucose | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus. |
| response to salt stress | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. |
| triglyceride biosynthetic process | The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8MK44 | DGAT1 | Diacylglycerol O-acyltransferase 1 | Bos taurus (Bovine) | PR |
| P35610 | SOAT1 | Sterol O-acyltransferase 1 | Homo sapiens (Human) | PR |
| O75907 | DGAT1 | Diacylglycerol O-acyltransferase 1 | Homo sapiens (Human) | PR |
| O88908 | Soat2 | Sterol O-acyltransferase 2 | Mus musculus (Mouse) | PR |
| Q9Z2A7 | Dgat1 | Diacylglycerol O-acyltransferase 1 | Mus musculus (Mouse) | PR |
| Q9ERM3 | Dgat1 | Diacylglycerol O-acyltransferase 1 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAILDSAGVT | TVTENGGGEF | VDLDRLRRRK | SRSDSSNGLL | LSGSDNNSPS | DDVGAPADVR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DRIDSVVNDD | AQGTANLAGD | NNGGGDNNGG | GRGGGEGRGN | ADATFTYRPS | VPAHRRARES |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PLSSDAIFKQ | SHAGLFNLCV | VVLIAVNSRL | IIENLMKYGW | LIRTDFWFSS | RSLRDWPLFM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| CCISLSIFPL | AAFTVEKLVL | QKYISEPVVI | FLHIIITMTE | VLYPVYVTLR | CDSAFLSGVT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LMLLTCIVWL | KLVSYAHTSY | DIRSLANAAD | KANPEVSYYV | SLKSLAYFMV | APTLCYQPSY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PRSACIRKGW | VARQFAKLVI | FTGFMGFIIE | QYINPIVRNS | KHPLKGDLLY | AIERVLKLSV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PNLYVWLCMF | YCFFHLWLNI | LAELLCFGDR | EFYKDWWNAK | SVGDYWRMWN | MPVHKWMVRH |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IYFPCLRSKI | PKTLAIIIAF | LVSAVFHELC | IAVPCRLFKL | WAFLGIMFQV | PLVFITNYLQ |
| 490 | 500 | 510 | |||
| ERFGSTVGNM | IFWFIFCIFG | QPMCVLLYYH | DLMNRKGSMS |