AiPD: Autoinhibited Protein Database

O75907

Gene name	DGAT1
Protein name	Diacylglycerol O-acyltransferase 1
Names	ACAT-related gene product 1, Acyl-CoA retinol O-fatty-acyltransferase, ARAT, Retinol O-fatty-acyltransferase, Diglyceride acyltransferase
Species	Homo sapiens (Human)
KEGG Pathway	hsa:8694
EC number	2.3.1.20: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-108 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-108 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

6 structures for O75907

Entry ID	Method	Resolution	Chain	Position	Source
6VP0	EM	310 A	C/E	1-488	PDB
6VYI	EM	300 A	A/B	1-488	PDB
6VZ1	EM	320 A	A/B	1-488	PDB
8ESM	EM	320 A	A/B	1-488	PDB
8ETM	EM	320 A	A/B	1-488	PDB
AF-O75907-F1	Predicted				AlphaFoldDB

434 variants for O75907

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1588689245 RCV001007932	2	G>missing	Congenital diarrhea 7 with exudative enteropathy [ClinVar]	Yes	ClinVar dbSNP
RCV000660629 RCV001584520 rs782577883 RCV002252199	210	S>missing	Congenital diarrhea 7 with exudative enteropathy [ClinVar]	Yes	ClinVar dbSNP
RCV001871823 CA4936939 RCV001331727 rs150434452	212	R>C	Congenital diarrhea 7 with exudative enteropathy [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
CA4936835 rs373363244 RCV001331728	269	R>C	Congenital diarrhea 7 with exudative enteropathy [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
RCV000988127 rs1554847435 CA372611513 RCV001858686	280	R>*	Congenital diarrhea 7 with exudative enteropathy [ClinVar]	Yes	gnomAD ClinGen ClinVar dbSNP
RCV000201459 CA279287 rs863225093	295	L>P	Congenital diarrhea 7 with exudative enteropathy [ClinVar]	Yes	ClinGen ClinVar TOPMed dbSNP
RCV000988126 rs1200919286	297	Q>missing	Congenital diarrhea 7 with exudative enteropathy [ClinVar]	Yes	ClinVar dbSNP
RCV001250059 rs374729844	358	R>P	Congenital diarrhea 7 with exudative enteropathy [ClinVar]	Yes	ClinVar dbSNP
CA372607900 rs1588680049 RCV000844891	437	Q>R	Congenital diarrhea 7 with exudative enteropathy [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
VAR_082141	458	W>del	DIAR7; unknown pathological significance [UniProt]	Yes	UniProt
RCV000599300 RCV002463455 rs1554847009	488	A>missing	Congenital diarrhea 7 with exudative enteropathy [ClinVar]	Yes	ClinVar dbSNP
rs1554848831 CA372613587	2	G>V		No	ClinGen Ensembl
rs1000216326 CA372613562	6	S>I		No	TOPMed gnomAD ClinGen
rs1000216326 CA187671704	6	S>N		No	ClinGen TOPMed gnomAD
rs1220548345 CA372613552	8	R>W		No	ClinGen TOPMed
rs1554848827 CA372613546	9	R>C		No	ClinGen gnomAD
rs572761204 CA187671693	9	R>L		No	ClinGen 1000Genomes TOPMed
CA372613540 rs1554848824	10	R>L		No	gnomAD ClinGen
CA187671689 rs1023036507	10	R>W		No	ClinGen Ensembl
CA372613529 rs1346485172	12	T>K		No	ClinGen TOPMed gnomAD
rs1554848820 CA372613524	13	G>W		No	gnomAD ClinGen
rs1440005282 CA372613511	15	R>Q		No	ClinGen TOPMed
rs1232613286 CA372613501	17	S>T		No	ClinGen TOPMed
CA4937155 rs782451896	18	S>C		No	ExAC TOPMed gnomAD ClinGen
CA372613494 rs1554848814	18	S>N		No	ClinGen Ensembl
rs1588689188 CA372613492	18	S>R		No	Ensembl ClinGen
CA372613464 rs1395990904	23	G>R		No	TOPMed ClinGen
CA372613460 rs1554848812	23	G>V		No	ClinGen gnomAD
rs1564634782 CA372613452	25	A>T		No	ClinGen Ensembl
CA372613446 rs1421743680	26	A>T		No	TOPMed gnomAD ClinGen
rs1554848809 CA372613435	27	A>V		No	gnomAD ClinGen
rs1352523419 CA372613418	30	E>K		No	ClinGen TOPMed
CA372613406 rs1554848804	31	V>G		No	ClinGen Ensembl
rs1012018639 CA187671686	31	V>M		No	TOPMed gnomAD ClinGen
rs1339503278 CA372613403	32	R>L		No	TOPMed gnomAD ClinGen
rs1299125683 CA372613404	32	R>W		No	TOPMed gnomAD ClinGen
CA372613398 rs1215640737	33	D>N		No	TOPMed ClinGen
CA372613375 rs1272967962	36	A>V		No	TOPMed ClinGen
CA372613354 rs1588689113	40	V>M		No	ClinGen Ensembl
CA372613339 rs1254033214	42	A>D		No	TOPMed gnomAD ClinGen
CA187671681 rs896359924	46	A>P		No	ClinGen Ensembl
CA187671680 rs1056778125	46	A>V		No	Ensembl ClinGen
rs1554848797 CA372613307	47	P>L		No	ClinGen gnomAD
rs1192022279 CA372613302	48	A>G		No	ClinGen TOPMed
rs1192022279 CA372613301	48	A>V		No	TOPMed ClinGen
rs1475811871 CA372613300	49	P>A		No	ClinGen TOPMed
CA4937151 rs781837106	50	A>D		No	ExAC TOPMed gnomAD ClinGen
CA4937152 rs781837106	50	A>V		No	ClinGen ExAC TOPMed gnomAD
CA187671672 rs564043345	51	P>A		No	ClinGen 1000Genomes TOPMed gnomAD
CA372613289 rs564043345	51	P>S		No	1000Genomes TOPMed gnomAD ClinGen
CA372613284 rs1554848794	52	N>D		No	gnomAD ClinGen
rs1393465924 CA372613281	52	N>S		No	TOPMed ClinGen
CA372613252 rs1554848793	56	D>G		No	gnomAD ClinGen
rs754699005 CA187671671	58	G>S		No	TOPMed ClinGen
rs1319932149 CA372613227	60	G>D		No	TOPMed gnomAD ClinGen
CA372613223 rs1326468776	61	S>G		No	TOPMed ClinGen
CA187671656 rs900239238	62	G>A		No	ClinGen TOPMed gnomAD
rs930349884 CA187671669	62	G>R		No	ClinGen Ensembl
rs1038824413 CA187671648	63	H>P		No	ClinGen TOPMed gnomAD
CA372613200 rs1554848786	64	W>L		No	ClinGen gnomAD
rs1554848784 CA372613185	66	L>P		No	ClinGen gnomAD
CA4937128 rs781879438	68	C>*		No	ClinGen ExAC gnomAD
CA187668892 rs947736352	68	C>G		No	ClinGen Ensembl
CA4937127 rs376209496	70	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs782106785 CA4937126	70	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC TOPMed gnomAD ClinGen NCI-TCGA
CA187668870 rs139748401	72	Q>*		No	ClinGen ESP TOPMed
CA372613108 rs940805896	75	L>F		No	ClinGen gnomAD
CA372613094 rs1210721884	77	S>I		No	TOPMed gnomAD ClinGen
CA372613095 rs1210721884	77	S>T		No	TOPMed gnomAD ClinGen
rs1449869280 CA372613090	78	S>P		No	TOPMed ClinGen
rs782421322 CA4937121	83	S>N		No	ExAC gnomAD ClinGen
rs782002327 CA4937119	85	Y>*		No	ExAC gnomAD ClinGen
rs189862978 CA4937118	88	I>V		No	ClinGen 1000Genomes ExAC gnomAD
CA372612993 rs1588685465	92	C>G		No	ClinGen Ensembl
CA4937117 rs782205654	93	V>A		No	ClinGen ExAC TOPMed gnomAD
CA372612982 rs782205654	93	V>E		No	ClinGen ExAC TOPMed gnomAD
rs1248515808 CA372612985	93	V>L		No	TOPMed gnomAD ClinGen
rs1288363749 CA372612936	98	L>W		No	ClinGen TOPMed
rs371984204 CA4937098	101	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs782047240 CA372612912	102	R>G		No	ClinGen ExAC TOPMed gnomAD
CA372612910 rs782036173	102	R>L		No	ClinGen ExAC TOPMed gnomAD
CA4937096 rs782036173	102	R>Q		No	ExAC TOPMed gnomAD ClinGen
rs782047240 CA4937097	102	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1588683583 CA372612908	103	L>V		No	Ensembl ClinGen
rs782257835 CA4937094	105	L>P		No	ExAC gnomAD ClinGen
rs1190139058 CA372612886	106	E>G		No	ClinGen TOPMed
CA372612872 rs868936483	108	L>I		No	ClinGen Ensembl
rs1554847800 CA372612862	109	I>M		No	ClinGen gnomAD
CA4937075 rs781998256	111	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA372612839 rs1374506621	111	Y>H		No	TOPMed ClinGen
rs1588683268 CA372612775	120	V>G		No	Ensembl ClinGen
rs1356774486 CA372612780	120	V>L		No	TOPMed ClinGen
CA187667413 rs147412095	123	L>V		No	ClinGen ESP TOPMed
CA372612740 rs1554847758	126	K>M		No	gnomAD ClinGen
rs782096599 CA4937073	127	D>E		No	ExAC TOPMed gnomAD ClinGen
rs782328055 CA4937072	128	P>H		No	ExAC gnomAD ClinGen
rs782328055 CA4937071	128	P>L		No	ClinGen ExAC gnomAD
CA4937069 rs782038069	130	S>G		No	ExAC gnomAD ClinGen
rs782259035 CA4937067	133	A>T		No	ExAC TOPMed gnomAD ClinGen
CA372612692 rs1344634935	133	A>V		No	TOPMed ClinGen
rs1554847752 CA372612677	136	L>M		No	gnomAD ClinGen
rs1275283451 CA372612668	137	V>A		No	TOPMed ClinGen
CA372612671 rs1554847749	137	V>L		No	ClinGen gnomAD
rs369275636 CA4937065	138	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA4937050 rs140443241	139	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs781953720 CA4937048	140	A>V		No	ExAC gnomAD ClinGen
CA4937047 rs150538509	141	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA372612627 rs1474773496	142	V>A		No	TOPMed ClinGen
rs1554847732 CA372612631	142	V>I		No	gnomAD ClinGen
rs1554847728 CA372612605	146	A>T		No	ClinGen gnomAD
CA372612595 rs1588683045	147	A>G		No	Ensembl ClinGen
RCV001299994 rs782393632 CA4937044	148	F>C		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs1564631871 CA372612585	149	Q>E		No	ClinGen Ensembl
CA372612582 rs1554847726	149	Q>R		No	ClinGen gnomAD
rs1166286615 CA372612568	151	E>G		No	ClinGen TOPMed
rs55907012 RCV000455264 CA4937042 RCV001517545	152	K>R		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA372612555 rs1554847721	153	R>C		No	gnomAD ClinGen
CA372612554 rs782459119	153	R>H		No	ClinGen ExAC TOPMed gnomAD
CA4937041 rs782459119	153	R>L		No	ExAC TOPMed gnomAD ClinGen
CA372612553 rs782459119	153	R>P		No	ClinGen ExAC TOPMed gnomAD
CA372612547 rs1554847719	155	A>T		No	ClinGen gnomAD
rs370746386 CA4937038	155	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1588682979 CA372612538	156	V>G		No	ClinGen Ensembl
rs781894452 CA4937036	156	V>M		No	ExAC gnomAD ClinGen
TCGA novel	157	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1422641494 CA372612525	157	G>S		No	TOPMed ClinGen
rs1554847676 CA372612519	158	A>T		No	ClinGen gnomAD
rs1554847673 CA372612514	158	A>V		No	ClinGen gnomAD
CA4937014 rs782534474	159	L>V		No	ClinGen ExAC gnomAD
rs530727318 CA4937013	160	T>M		No	1000Genomes ExAC TOPMed gnomAD ClinGen
rs1439487383 CA372612498	161	E>D		No	TOPMed ClinGen
CA372612503 rs1554847656	161	E>Q		No	ClinGen gnomAD
rs1157034260 CA372612496	162	Q>K		No	TOPMed ClinGen
CA4937012 rs563377054	163	A>V		No	1000Genomes ExAC TOPMed gnomAD ClinGen
CA372612482 rs1554847652	164	G>R		No	gnomAD ClinGen
rs142277695 CA372612456	168	H>Q		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
CA4937010 rs375840448	168	H>Y		No	ESP ExAC TOPMed gnomAD ClinGen
rs144065666 CA4937008	169	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1305131804 CA372612445	170	A>V		No	TOPMed ClinGen
rs1588682660 CA372612441	171	N>T		No	ClinGen Ensembl
rs782041538 CA4937007	172	L>V		No	ExAC TOPMed gnomAD ClinGen
CA372612425 rs1554847642	174	T>P		No	ClinGen gnomAD
CA187667134 rs372303345	177	C>R		No	ESP TOPMed ClinGen
rs139015645 CA372612385	180	A>E		No	ESP ExAC TOPMed gnomAD ClinGen
CA4937003 rs782271176	180	A>S		No	ExAC gnomAD ClinGen
CA4937002 rs139015645	180	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA372612370 rs1397098169	183	V>I		No	TOPMed gnomAD ClinGen
CA4936995 rs782648879	185	L>P		No	ExAC TOPMed gnomAD ClinGen
rs1554847632 CA372612351	186	V>G		No	ClinGen gnomAD
CA372612348 rs1554847629	187	E>K		No	ClinGen gnomAD
CA372612343 rs1554847625	187	E>V		No	ClinGen gnomAD
rs1564631641 CA372612337	188	S>C		No	ClinGen Ensembl
rs1375938425 CA372612338	188	S>P		No	ClinGen TOPMed
rs782798411 CA4936994	189	I>V		No	ExAC TOPMed gnomAD ClinGen
CA4936992 rs782722986	190	T>I		No	ExAC TOPMed gnomAD ClinGen
CA187667056 rs994314695	192	V>M		No	Ensembl ClinGen
CA372612300 rs1554847593	193	G>S		No	gnomAD ClinGen
CA372612292 rs1275617500	194	S>A		No	ClinGen TOPMed
rs1221343847 CA372612273	197	A>V		No	TOPMed gnomAD ClinGen
CA372612270 rs1554847582	198	L>R		No	ClinGen gnomAD
rs368297805 CA4936951	200	A>V		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
rs1554847579 CA372612246	201	H>Q		No	ClinGen gnomAD
rs782481578 CA4936949	202	T>N		No	ExAC TOPMed gnomAD ClinGen
rs1588682296 CA372612245	202	T>P		No	ClinGen Ensembl
CA4936948 rs781816553	203	I>V		No	ExAC gnomAD ClinGen
CA4936946 rs782559118	204	L>F		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	205	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	205	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1554847572 CA372612207	208	L>I		No	gnomAD ClinGen
rs142970193 RCV001309677 CA4936945	209	F>S		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs138248019 CA4936943	210	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA4936940 rs150434452	212	R>G		No	ESP ExAC TOPMed gnomAD ClinGen
rs373569005 CA4936938	212	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA4936936 rs782137876	213	D>N		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	214	V>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM1455600 rs377729741 CA4936935	214	V>I	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA4936933 rs782209618	217	W>*		No	ExAC gnomAD ClinGen
rs782360151 CA4936934	217	W>R		No	ExAC ClinGen
rs781947496 CA4936932	218	C>F		No	ExAC gnomAD ClinGen
rs782313741 CA4936931	219	R>C		No	ExAC gnomAD ClinGen
CA4936930 rs782303747	219	R>H		No	ExAC TOPMed gnomAD ClinGen
rs782313741 CA372612138	219	R>S		No	ExAC gnomAD ClinGen
COSM310540 rs782671953 CA4936929	220	R>G	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA372612131 rs1554847559	220	R>T		No	ClinGen gnomAD
rs1285605631 CA372612128	221	A>T		No	ClinGen TOPMed gnomAD
CA187666743 rs890035654	222	R>G		No	TOPMed ClinGen
CA372612121 rs1213164340	222	R>K		No	ClinGen TOPMed
CA372612116 rs1554847558 COSM1132812	223	A>T	Variant assessed as Somatic; 0.0 impact. prostate [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA4936928 rs782500416	224	K>E		No	ExAC TOPMed gnomAD ClinGen
CA4936897 rs782452538	227	S>F		No	ExAC TOPMed gnomAD ClinGen
CA372612059 rs1403139054	230	K>R		No	TOPMed ClinGen
CA4936894 rs782148617	231	K>E		No	ClinGen ExAC TOPMed gnomAD
CA4936893 rs781875216	231	K>T		No	ClinGen ExAC TOPMed gnomAD
rs782733856	231	K>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA4936891 rs140478833	232	A>T		No	ClinGen 1000Genomes ESP TOPMed gnomAD
CA4936890 rs782740287	233	S>G		No	ClinGen ExAC TOPMed gnomAD
rs370182734 CA187666531	233	S>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA gnomAD
rs1554847519 CA372612039	233	S>R		No	gnomAD ClinGen
rs1554847518 CA372612029	235	A>P		No	ClinGen gnomAD
CA4936889 rs782078569	235	A>V		No	ClinGen ExAC gnomAD
CA187666502 rs935852307	236	A>T		No	ClinGen gnomAD
rs1554847515 CA372612023	236	A>V		No	ClinGen gnomAD
rs373467033 RCV001341598 CA4936887	238	P>L		No	1000Genomes ExAC TOPMed gnomAD ClinGen ClinVar dbSNP
CA372612012 rs1554847514	238	P>S		No	gnomAD ClinGen
CA4936886 rs782161523	239	H>P		No	ClinGen ExAC gnomAD
CA4936884 rs782391605	241	V>M		No	ExAC TOPMed gnomAD ClinGen
CA372611987 rs782238113	242	S>I		No	ExAC gnomAD ClinGen
CA4936883 rs782238113	242	S>N		No	ClinGen ExAC gnomAD
CA4936882 rs146322937	243	Y>H		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
CA4936881 rs367844653	244	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ESP ExAC TOPMed gnomAD ClinGen NCI-TCGA
rs782569114 CA4936879	246	N>S		No	ClinGen ExAC gnomAD
rs1476738638 CA372611956	247	L>V		No	TOPMed ClinGen
CA372611948 rs55962377	248	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
RCV000455982 RCV001510557 rs55962377 CA4936878	248	T>N		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs55962377 CA372611949	248	T>S		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
rs782707652	250	R>=	Variant assessed as Somatic; 5.697e-05 impact. [NCI-TCGA]	No	NCI-TCGA
CA4936876 rs144473757	250	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs144473757 CA372611938	250	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA4936875 rs782187957	250	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA4936874 rs782187957	250	R>L		No	ExAC TOPMed gnomAD ClinGen
rs782043842 CA4936872	251	D>N		No	ExAC TOPMed gnomAD ClinGen
CA4936850 rs781822558	252	L>F		No	ClinGen ExAC gnomAD
CA372611916 rs1554847477	252	L>P		No	ClinGen gnomAD
rs782501227 CA4936849	255	F>L		No	ClinGen ExAC TOPMed gnomAD
rs782046312 CA4936848	255	F>Y		No	ExAC TOPMed gnomAD ClinGen
rs782802515 CA4936846	256	L>F		No	ExAC gnomAD ClinGen
RCV001302410 rs144983092 CA4936844	258	A>T		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs782187728 CA4936842	260	T>N		No	ExAC TOPMed gnomAD ClinGen
CA372611751 rs1342245507	264	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	TOPMed ClinGen NCI-TCGA
rs146196839 CA4936837 RCV000483585	266	N>S		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA372611696 rs1218270729	267	F>V		No	ClinGen TOPMed
rs1487655734 CA372611666	268	P>L		No	ClinGen TOPMed gnomAD
rs141523495 CA4936836	268	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA4936834 rs139792712	269	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs781791106 CA187666243	270	S>F		No	ClinGen ExAC gnomAD
CA4936833 rs781791106	270	S>Y		No	ExAC gnomAD ClinGen
rs782804473 CA4936832	271	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA372611627 rs782804473	271	P>R		No	ClinGen ExAC TOPMed gnomAD
rs782553235 CA4936831	272	R>C		No	ExAC TOPMed gnomAD ClinGen
rs1554847442 CA372611617	272	R>H		No	gnomAD ClinGen
CA4936829 rs146155230	273	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA4936830 rs781882807	273	I>T		No	ExAC gnomAD ClinGen
CA4936826 rs782702737	274	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs199537660 CA4936828	274	R>W		No	ESP ExAC TOPMed gnomAD ClinGen
CA4936825 rs782152635	275	K>N		No	ClinGen ExAC TOPMed gnomAD
CA4936824 rs376764170	276	R>C		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
CA187666228 rs1044230336	276	R>H		No	gnomAD ClinGen
CA4936823 rs782383355	280	R>Q		No	ExAC gnomAD ClinGen
rs781969331 CA4936821	281	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA4936822 rs782247930	281	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1333447982 CA372611498	282	I>V		No	ClinGen TOPMed gnomAD
CA4936792 rs782250375	289	T>I		No	ExAC gnomAD ClinGen
CA372610060 rs782349298	290	Q>*		No	ClinGen ExAC TOPMed gnomAD
CA4936790 rs782349298	290	Q>E		No	ClinGen ExAC TOPMed gnomAD
rs1588681427 CA372610006	293	V>G		No	ClinGen Ensembl
CA4936788 rs782679330	293	V>M		No	ClinGen ExAC gnomAD
CA372610001 rs1255944622	294	G>R		No	TOPMed ClinGen
CA372609870 rs1554847371	299	W>R		No	ClinGen gnomAD
rs782593895 CA4936767	301	V>G		No	ExAC gnomAD ClinGen
CA4936764 rs782684202	303	T>P		No	ClinGen ExAC gnomAD
rs782541395 CA4936763	304	I>L		No	ExAC ClinGen
CA4936762 rs781874038	304	I>T		No	ClinGen ExAC
rs1002226053 CA187664686	305	Q>*		No	gnomAD ClinGen
rs750514290 TCGA novel CA187664681	305	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA TOPMed ClinGen
CA4936761 rs782768563	306	N>K		No	ClinGen ExAC
CA4936759 rs781830211	310	P>L		No	ExAC gnomAD ClinGen
rs1298473057 CA372609688	310	P>S		No	ClinGen TOPMed gnomAD
rs1221062147 CA372609645	312	K>N		No	ClinGen TOPMed
rs782751829 CA372609588	313	D>N		No	ExAC gnomAD ClinGen
rs782751829 CA4936747	313	D>Y		No	ExAC gnomAD ClinGen
rs1554847343 CA372609565	314	M>T		No	gnomAD ClinGen
rs782508433 CA4936746	318	R>C		No	ExAC TOPMed gnomAD ClinGen
rs782127562 CA187664632	318	R>H		No	ClinGen Ensembl
CA372609493 rs1400043688	319	I>V		No	ClinGen TOPMed
CA372609465 rs782019712	320	I>M		No	ExAC gnomAD ClinGen
CA4936743 rs782473207	321	E>K		No	ClinGen ExAC TOPMed gnomAD
rs781798132 CA4936742	322	R>C		No	ExAC TOPMed gnomAD ClinGen
rs1315358048 CA372609441	322	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	TOPMed ClinGen NCI-TCGA
rs1588681106 CA372609399	325	K>R		No	ClinGen Ensembl
CA4936738 rs782741298	326	L>Q		No	ClinGen ExAC gnomAD
rs143753756	327	A>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA187664588 rs782806278	327	A>G		No	Ensembl ClinGen
TCGA novel	330	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1554847296 CA372609256	331	H>R		No	ClinGen gnomAD
CA372609219 rs1157666041	333	I>M		No	TOPMed ClinGen
CA372609232 rs1554847295	333	I>V		No	gnomAD ClinGen
TCGA novel	334	W>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs782741492 CA4936709	335	L>F		No	ClinGen ExAC gnomAD
rs782090603 CA4936708	336	I>V		No	ClinGen ExAC TOPMed gnomAD
CA4936706 rs782321541	337	F>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC TOPMed gnomAD ClinGen NCI-TCGA
CA4936705 rs149384210	337	F>L		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
CA372609164 rs782321541	337	F>V		No	ExAC TOPMed gnomAD ClinGen
CA372609135 rs1452388257	338	F>L		No	TOPMed ClinGen
rs1554847292 CA372609142	338	F>S		No	gnomAD ClinGen
rs782575471 RCV000486981	338	F>missing		No	ClinVar dbSNP
rs782372012 CA4936703	339	Y>F		No	ExAC ClinGen
CA4936701 rs782220518	340	W>*		No	ClinGen ExAC TOPMed gnomAD
CA372609115 rs1379566453	340	W>G		No	TOPMed ClinGen
CA372609063 rs1554847289	343	H>D		No	ClinGen gnomAD
CA372609058 rs1554847288	343	H>R		No	ClinGen gnomAD
rs782605020 CA4936700	346	L>P		No	ClinGen ExAC gnomAD
rs372199680 CA4936698	349	V>M		No	ClinGen ESP ExAC gnomAD
CA372608967 rs1554847284	350	A>T		No	ClinGen TOPMed
rs1554847283 CA372608939	352	L>P		No	ClinGen gnomAD
rs1015415172 CA187664448	353	M>L		No	ClinGen gnomAD
rs1220974369 CA372608927	353	M>R		No	ClinGen TOPMed gnomAD
CA372608919 rs1279269744	354	Q>*		No	TOPMed ClinGen
rs782538538 CA4936696	354	Q>R		No	ExAC TOPMed gnomAD ClinGen
rs1004476805 CA187664430	357	D>N		No	Ensembl ClinGen
CA4936695 rs374729844	358	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA372608865 rs1554847278	358	R>W		No	gnomAD ClinGen
CA4936693 rs782498938	361	Y>C		No	ClinGen ExAC gnomAD
rs138800445 CA372608814	362	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs138800445 CA4936691	362	R>Q		No	ESP ExAC TOPMed gnomAD ClinGen
CA4936692 rs781826408	362	R>W		No	ExAC TOPMed gnomAD ClinGen
CA372608808 rs1554847271	363	D>Y		No	ClinGen gnomAD
CA372608672 rs1245682495	368	E>K		No	TOPMed gnomAD ClinGen
CA4936662 rs782702763	370	V>I		No	ClinGen ExAC gnomAD
CA4936661 rs782156730	371	T>I		No	ExAC gnomAD ClinGen
rs1554847242 CA372608603	372	Y>C		No	ClinGen gnomAD
TCGA novel	373	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4936660 rs782015251	374	W>R		No	ClinGen ExAC TOPMed gnomAD
CA4936659 rs782781880	375	Q>*		No	ExAC gnomAD ClinGen
rs1554847239 CA372608507	377	W>*		No	ClinGen gnomAD
rs782118993 CA4936658	377	W>R		No	ExAC gnomAD ClinGen
CA187664235 rs1802327	378	N>K		No	Ensembl ClinGen
rs146441969 CA4936657	380	P>L		No	ClinGen ESP ExAC gnomAD
CA4936656 rs782347377	381	V>A		No	ExAC gnomAD ClinGen
CA4936655 rs782198587	385	C>Y		No	ClinGen ExAC TOPMed gnomAD
CA372608307 rs1554847202	388	H>L		No	ClinGen gnomAD
rs782749127 CA4936636	388	H>Y		No	ExAC TOPMed gnomAD ClinGen
CA4936635 rs782087919	390	Y>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1554847198 CA372608289	391	K>E		No	ClinGen gnomAD
rs1316105193 CA372608270	393	M>V		No	ClinGen TOPMed gnomAD
CA4936634 rs372817613	395	R>*		No	ESP ExAC TOPMed gnomAD ClinGen
CA4936633 rs782164877	395	R>P		No	ClinGen ExAC TOPMed gnomAD
CA4936632 rs782164877	395	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs193169779 CA372608244	396	R>L		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
rs193169779 CA4936630	396	R>Q		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
rs375843442 CA4936631	396	R>W		No	ESP ExAC TOPMed gnomAD ClinGen
rs1554847196 CA372608238	397	G>S		No	ClinGen gnomAD
CA372608225 rs1286186671	398	S>R		No	ClinGen TOPMed
rs782091446 CA4936629	399	S>T		No	ExAC TOPMed gnomAD ClinGen
CA372608189 rs1554847192	402	M>I		No	gnomAD ClinGen
CA372608194 rs1205104526	402	M>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA372608195 rs1205104526	402	M>V		No	TOPMed gnomAD ClinGen
rs781948192 CA4936628	403	A>S		No	ClinGen ExAC gnomAD
CA4936627 rs782323808	404	R>G		No	ExAC gnomAD ClinGen
CA4936626 rs782179106	405	T>I		No	ClinGen ExAC TOPMed gnomAD
CA4936624 rs377582872	406	G>R		No	ESP ExAC TOPMed gnomAD ClinGen
rs782641412 CA4936620	407	V>A		No	ExAC gnomAD ClinGen
CA372608154 rs782641412	407	V>G		No	ClinGen ExAC gnomAD
rs1180732436 CA372608138	409	L>P		No	TOPMed ClinGen
rs1554847183 CA372608133	410	A>P		No	gnomAD ClinGen
CA372608132 rs1554847183	410	A>T		No	ClinGen gnomAD
rs573410614 CA4936618	411	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC gnomAD ClinGen NCI-TCGA
TCGA novel	411	S>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1453106665 CA372608115	412	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	TOPMed ClinGen NCI-TCGA
CA4936615 rs781911802	413	F>L		No	ClinGen ExAC TOPMed gnomAD
rs782802659 CA4936614	414	F>L		No	ClinGen ExAC gnomAD
CA4936613 rs782136994	414	F>L		No	ExAC gnomAD ClinGen
CA372608101 rs782802659	414	F>V		No	ExAC gnomAD ClinGen
rs1335759761 CA372608087	416	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	TOPMed gnomAD ClinGen NCI-TCGA
rs782116263 CA4936589	417	Y>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1554847146 CA372608049	419	V>L		No	gnomAD ClinGen
CA16605211 rs372051069 RCV000436889	420	S>R		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs782744860 CA4936587	421	V>D		No	ExAC TOPMed gnomAD ClinGen
rs1554847144 CA372608034	421	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA372608024 rs1554847140	422	P>L		No	ClinGen gnomAD
CA4936584 rs782420668	424	R>*		No	ExAC gnomAD ClinGen
rs782420668 CA372608010	424	R>G		No	ExAC gnomAD ClinGen
CA372608008 rs782284944	424	R>P		No	ClinGen ExAC TOPMed gnomAD
CA4936583 rs782284944	424	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1588680098 CA372607990	426	F>S		No	ClinGen Ensembl
CA187663961 rs782354909	427	R>C		No	TOPMed gnomAD ClinGen
rs147655123 CA4936582	427	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ESP ExAC TOPMed gnomAD ClinGen NCI-TCGA
CA4936581 rs782381938	428	L>F		No	ClinGen ExAC TOPMed gnomAD
CA372607969 rs1554847135	429	W>G		No	ClinGen gnomAD
rs1554847132 CA372607957	430	A>V		No	ClinGen gnomAD
CA372607942 rs369376240	432	T>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA4936579 rs369376240	432	T>M		No	ESP ExAC TOPMed gnomAD ClinGen
rs918197083 CA187663941	433	G>D		No	TOPMed ClinGen
rs1427058220 CA372607929	434	M>L		No	ClinGen TOPMed gnomAD
rs1554847124 CA372607927	434	M>T		No	gnomAD ClinGen
CA372607902 rs1564630278	437	Q>*		No	Ensembl ClinGen
CA372607884 rs1554847075	438	I>V		No	ClinGen gnomAD
rs1554847073 CA372607874	439	P>L		No	ClinGen gnomAD
rs782802480 CA4936547	439	P>S		No	ClinGen ExAC gnomAD
CA4936544 rs782395919	442	W>*		No	ClinGen ExAC TOPMed gnomAD
rs367717255 CA4936542	444	V>M		No	ESP ExAC TOPMed gnomAD ClinGen
rs782199338 CA4936540	446	R>C		No	ExAC TOPMed gnomAD ClinGen
rs782420067 CA4936539	446	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC TOPMed gnomAD ClinGen NCI-TCGA
rs782420067 CA4936538	446	R>L		No	ClinGen ExAC TOPMed gnomAD
CA372607818 rs782420067	446	R>P		No	ClinGen ExAC TOPMed gnomAD
rs782199338 CA372607820	446	R>S		No	ExAC TOPMed gnomAD ClinGen
CA4936536 rs140874999	448	F>L		No	ESP ExAC TOPMed gnomAD ClinGen
TCGA novel	448	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1554847066 CA372607794	449	Q>R		No	ClinGen gnomAD
CA372607788 rs868942419	450	G>S		No	ClinGen TOPMed
rs781828606 CA4936534	450	G>V		No	ClinGen ExAC gnomAD
rs782542875 CA4936532	452	Y>C		No	ExAC TOPMed gnomAD ClinGen
rs782769518 CA372607764	453	G>A		No	ClinGen ExAC gnomAD
CA4936530 rs782769518	453	G>D		No	ExAC gnomAD ClinGen
rs1345060234 CA372607768	453	G>S		No	ClinGen TOPMed gnomAD
rs984784208 CA187663607	455	A>E		No	ClinGen gnomAD
rs1452091909 CA372607752	455	A>T		No	TOPMed gnomAD ClinGen
rs1554847063 CA372607739	456	A>V		No	gnomAD ClinGen
rs1554847060 CA372607733	457	V>A		No	ClinGen TOPMed
rs782739596 CA4936527	458	W>*		No	ExAC gnomAD ClinGen
rs1339186687 CA372607723	458	W>S		No	ClinGen TOPMed gnomAD
rs1564630093 CA372607715	459	L>P		No	ClinGen Ensembl
rs782201907 CA187663599	460	S>L		No	ClinGen gnomAD
rs781932849 CA4936525	461	L>F		No	ClinGen ExAC gnomAD
CA4936524 rs782407267	461	L>P		No	ClinGen ExAC gnomAD
CA372607690 rs1554847046	462	I>M		No	ClinGen gnomAD
CA372607696 rs1554847048	462	I>V		No	ClinGen gnomAD
rs781984067 CA4936522	463	I>V		No	ExAC gnomAD ClinGen
rs782201166 CA4936520	464	G>R		No	ExAC TOPMed gnomAD ClinGen
CA372607653 rs1224362971	467	I>T		No	TOPMed ClinGen
rs782330158 CA4936518	468	A>T		No	ClinGen ExAC gnomAD
rs782689595 CA4936516	469	V>I		No	ExAC TOPMed gnomAD ClinGen
TCGA novel	471	M>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA372607624 rs1554847035	471	M>V		No	gnomAD ClinGen
CA4936513 rs782605643	473	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1031073510 CA187663524	475	D>E		No	Ensembl ClinGen
rs782726552 CA4936510	476	Y>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC gnomAD ClinGen NCI-TCGA
CA372607584 rs1554847030	476	Y>H		No	ClinGen gnomAD
CA372607572 rs782526221	477	Y>*		No	ClinGen ExAC TOPMed gnomAD
rs543553010 CA4936508	479	L>F		No	ClinGen 1000Genomes ExAC gnomAD
CA372607542 rs1554847027	481	Y>C		No	ClinGen gnomAD
CA4936505 rs200430497 RCV001729745 RCV000914877	485	A>V		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA4936502 rs782043081	487	E>G		No	ClinGen ExAC gnomAD
CA372607505 rs868957042	487	E>K		No	ClinGen gnomAD
CA4936501 rs782022899	488	A>T		No	ClinGen ExAC gnomAD

1 associated diseases with O75907

[MIM: 615863]: Diarrhea 7, protein-losing enteropathy type (DIAR7)

A life-threatening disease characterized by severe, intractable, watery diarrhea. {ECO:0000269|PubMed:23114594, ECO:0000269|PubMed:30237576}. Note=The disease is caused by variants affecting the gene represented in this entry.

Without disease ID

A life-threatening disease characterized by severe, intractable, watery diarrhea. {ECO:0000269|PubMed:23114594, ECO:0000269|PubMed:30237576}. Note=The disease is caused by variants affecting the gene represented in this entry.

No regional properties for O75907

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for O75907

Functions

		Description
EC Number	2.3.1.20	Transferring groups other than amino-acyl groups
Subcellular Localization	Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
specific granule membrane	The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.

6 GO annotations of molecular function

Name	Definition
2-acylglycerol O-acyltransferase activity	Catalysis of the reaction: acyl-CoA + 2-acylglycerol = CoA + diacylglycerol.
acyltransferase activity	Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).
diacylglycerol O-acyltransferase activity	Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.
identical protein binding	Binding to an identical protein or proteins.
O-acyltransferase activity	Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule.
retinol O-fatty-acyltransferase activity	Catalysis of the reaction: acyl-CoA + retinol = CoA + retinyl ester.

8 GO annotations of biological process

Name	Definition
diacylglycerol metabolic process	The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group.
fatty acid homeostasis	Any process involved in the maintenance of an internal steady state of fatty acid within an organism or cell.
lipid storage	The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.
long-chain fatty-acyl-CoA metabolic process	The chemical reactions and pathways involving long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more.
monoacylglycerol biosynthetic process	The chemical reactions and pathways resulting in the formation of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified.
triglyceride biosynthetic process	The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol.
triglyceride metabolic process	The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins.
very-low-density lipoprotein particle assembly	The non-covalent aggregation and arrangement of proteins and lipids in the liver to form a very-low-density lipoprotein particle.

6 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8MK44	DGAT1	Diacylglycerol O-acyltransferase 1	Bos taurus (Bovine)	PR
P35610	SOAT1	Sterol O-acyltransferase 1	Homo sapiens (Human)	PR
O88908	Soat2	Sterol O-acyltransferase 2	Mus musculus (Mouse)	PR
Q9Z2A7	Dgat1	Diacylglycerol O-acyltransferase 1	Mus musculus (Mouse)	PR
Q9ERM3	Dgat1	Diacylglycerol O-acyltransferase 1	Rattus norvegicus (Rat)	PR
Q9SLD2	DGAT1	Diacylglycerol O-acyltransferase 1	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MGDRGSSRRR	RTGSRPSSHG	GGGPAAAEEE	VRDAAAGPDV	GAAGDAPAPA	PNKDGDAGVG
70	80	90	100	110	120
SGHWELRCHR	LQDSLFSSDS	GFSNYRGILN	WCVVMLILSN	ARLFLENLIK	YGILVDPIQV
130	140	150	160	170	180
VSLFLKDPYS	WPAPCLVIAA	NVFAVAAFQV	EKRLAVGALT	EQAGLLLHVA	NLATILCFPA
190	200	210	220	230	240
AVVLLVESIT	PVGSLLALMA	HTILFLKLFS	YRDVNSWCRR	ARAKAASAGK	KASSAAAPHT
250	260	270	280	290	300
VSYPDNLTYR	DLYYFLFAPT	LCYELNFPRS	PRIRKRFLLR	RILEMLFFTQ	LQVGLIQQWM
310	320	330	340	350	360
VPTIQNSMKP	FKDMDYSRII	ERLLKLAVPN	HLIWLIFFYW	LFHSCLNAVA	ELMQFGDREF
370	380	390	400	410	420
YRDWWNSESV	TYFWQNWNIP	VHKWCIRHFY	KPMLRRGSSK	WMARTGVFLA	SAFFHEYLVS
430	440	450	460	470	480
VPLRMFRLWA	FTGMMAQIPL	AWFVGRFFQG	NYGNAAVWLS	LIIGQPIAVL	MYVHDYYVLN

YEAPAAEA