Q8MK44

PR
Gene name
DGAT1
Protein name
Diacylglycerol O-acyltransferase 1
Names
Acyl-CoA retinol O-fatty-acyltransferase, ARAT, Retinol O-fatty-acyltransferase, Diglyceride acyltransferase
Species
Bos taurus (Bovine)
KEGG Pathway
bta:282609
EC number
2.3.1.20: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-97 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8MK44

Entry ID Method Resolution Chain Position Source
AF-Q8MK44-F1 Predicted AlphaFoldDB

1 variants for Q8MK44

Variant ID(s) Position Change Description Diseaes Association Provenance
232 K>A No

No associated diseases with Q8MK44

No regional properties for Q8MK44

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q8MK44

Functions

Description
EC Number 2.3.1.20 Transferring groups other than amino-acyl groups
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

3 GO annotations of molecular function

Name Definition
diacylglycerol O-acyltransferase activity Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.
O-acyltransferase activity Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule.
retinol O-fatty-acyltransferase activity Catalysis of the reaction: acyl-CoA + retinol = CoA + retinyl ester.

3 GO annotations of biological process

Name Definition
diacylglycerol metabolic process The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group.
monoacylglycerol biosynthetic process The chemical reactions and pathways resulting in the formation of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified.
triglyceride biosynthetic process The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P35610 SOAT1 Sterol O-acyltransferase 1 Homo sapiens (Human) PR
O75907 DGAT1 Diacylglycerol O-acyltransferase 1 Homo sapiens (Human) PR
O88908 Soat2 Sterol O-acyltransferase 2 Mus musculus (Mouse) PR
Q9Z2A7 Dgat1 Diacylglycerol O-acyltransferase 1 Mus musculus (Mouse) PR
Q9ERM3 Dgat1 Diacylglycerol O-acyltransferase 1 Rattus norvegicus (Rat) PR
Q9SLD2 DGAT1 Diacylglycerol O-acyltransferase 1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MGDRGGAGGS RRRRTGSRPS IQGGSGPAAA EEEVRDVGAG GDAPVRDTDK DGDVDVGSGH
70 80 90 100 110 120
WDLRCHRLQD SLFSSDSGFS NYRGILNWCV VMLILSNARL FLENLIKYGI LVDPIQVVSL
130 140 150 160 170 180
FLKDPYSWPA LCLVIVANIF AVAAFQVEKR LAVGALTEQA GLLLHGVNLA TILCFPAAVA
190 200 210 220 230 240
FLLESITPVG SVLALMVYTI LFLKLFSYRD VNLWCRERRA GAKAKAALAG KKANGGAAQR
250 260 270 280 290 300
TVSYPDNLTY RDLYYFLFAP TLCYELNFPR SPRIRKRFLL RRLLEMLFLT QLQVGLIQQW
310 320 330 340 350 360
MVPAIQNSMK PFKDMDYSRI VERLLKLAVP NHLIWLIFFY WLFHSCLNAV AELMQFGDRE
370 380 390 400 410 420
FYRDWWNSES ITYFWQNWNI PVHKWCIRHF YKPMLRRGSS KWAARTAVFL ASAFFHEYLV
430 440 450 460 470 480
SIPLRMFRLW AFTGMMAQIP LAWIVGRFFR GNYGNAAVWL SLIIGQPVAV LMYVHDYYVL
NREAPAAGT