AiPD: Autoinhibited Protein Database

Gene name	Soat2
Protein name	Sterol O-acyltransferase 2
Names	Acyl-coenzyme A:cholesterol acyltransferase 2, ACAT-2, Cholesterol acyltransferase 2
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:223920
EC number	2.3.1.26: Transferring groups other than amino-acyl groups
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-125 (Predicted disordered autoinhibitory region) PR

1-125 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-O88908-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs32348381	29	A>E	No	EVA
rs32178566	33	G>R	No	EVA
rs3389386735	107	K>R	No	EVA
rs3389364271	116	V>E	No	EVA
rs3389393508	127	I>M	No	EVA
rs260100472	185	W>R	No	EVA
rs3389396197	199	G>E	No	EVA
rs242821420	205	V>I	No	EVA
rs253644275	224	R>K	No	EVA
rs3389344300	238	E>K	No	EVA
rs3389400385	259	C>Y	No	EVA
rs3389344319	264	K>T	No	EVA
rs3389355141	273	S>R	No	EVA
rs248744514	288	T>S	No	EVA
rs3389391007	292	T>A	No	EVA
rs3389374199	341	L>I	No	EVA
rs3389384780	384	W>*	No	EVA
rs3389410284	417	L>S	No	EVA
rs3389393480	432	V>M	No	EVA
rs251184481	459	F>I	No	EVA
rs3389310772	473	G>S	No	EVA
rs3389388735	475	A>V	No	EVA
rs3389400371	493	S>G	No	EVA
rs3389390628	524	H>L	No	EVA
rs3389403910	524	H>Y	No	EVA

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for O88908

		Description
EC Number	2.3.1.26	Transferring groups other than amino-acyl groups
Subcellular Localization	Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
brush border	The dense covering of microvilli on the apical surface of an epithelial cell in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

Name	Definition
cholesterol binding	Binding to cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
cholesterol O-acyltransferase activity	Catalysis of the reaction: acyl-CoA + cholesterol = a cholesterol ester + CoA.
fatty-acyl-CoA binding	Binding to a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group.
O-acyltransferase activity	Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule.
sterol O-acyltransferase activity	Catalysis of the reaction: acyl-CoA + a sterol = CoA + a sterol ester.

Name	Definition
cholesterol efflux	The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.
cholesterol esterification	A lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle.
cholesterol homeostasis	Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
cholesterol metabolic process	The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.
very-low-density lipoprotein particle assembly	The non-covalent aggregation and arrangement of proteins and lipids in the liver to form a very-low-density lipoprotein particle.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8MK44	DGAT1	Diacylglycerol O-acyltransferase 1	Bos taurus (Bovine)	PR
P35610	SOAT1	Sterol O-acyltransferase 1	Homo sapiens (Human)	PR
O75907	DGAT1	Diacylglycerol O-acyltransferase 1	Homo sapiens (Human)	PR
Q9Z2A7	Dgat1	Diacylglycerol O-acyltransferase 1	Mus musculus (Mouse)	PR
Q9ERM3	Dgat1	Diacylglycerol O-acyltransferase 1	Rattus norvegicus (Rat)	PR
Q9SLD2	DGAT1	Diacylglycerol O-acyltransferase 1	Arabidopsis thaliana (Mouse-ear cress)	PR