AiPD: Autoinhibited Protein Database

Gene name	SYT1 (SYTA, At2g20990, F26H11.25, F5H14.5)
Protein name	Synaptotagmin-1
Names	NTMC2T1.1, Synaptotagmin A
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT2G20990
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

213-497 (Predicted disordered autoinhibitory region) PR

213-497 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
7AS6	X-ray	200 A	A	253-397	PDB
7ATP	X-ray	210 A	A	253-397	PDB
AF-Q9SKR2-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
tmp_2_9014887_C_T	21	L>F		No	1000Genomes
tmp_2_9015239_G_A	48	D>N		No	1000Genomes
ENSVATH00240906	84	Y>F		No	1000Genomes
ENSVATH14526711	125	P>L		No	1000Genomes
tmp_2_9016696_G_T	246	V>F		No	1000Genomes
tmp_2_9016867_A_C	274	K>Q		No	1000Genomes
ENSVATH05545125	278	M>I		No	1000Genomes
ENSVATH13307605	337	G>V		No	1000Genomes
ENSVATH05545126	338	N>S		No	1000Genomes
ENSVATH00240910	339	P>A		No	1000Genomes
ENSVATH00240911	357	H>Q	Plants were checked bi-weekly for presence of first buds and the average flowering time of 4 plants of the same accession were collected [16c and 16 hrs daylight] Plants were checked bi-weekly for presence of first buds and the average flowering time of 4 plants of the same accession were collected [22c and 16 hrs daylight] [EnsemblGenome]	No	1000Genomes
ENSVATH13307606	357	H>Y		No	1000Genomes
ENSVATH13307607	363	E>A		No	1000Genomes
ENSVATH13307608	370	G>S		No	1000Genomes
ENSVATH05545129	371	G>D		No	1000Genomes
ENSVATH05545130	387	E>A		No	1000Genomes
tmp_2_9017304_G_C	395	E>D		No	1000Genomes
tmp_2_9017371_G_T	418	A>S		No	1000Genomes
tmp_2_9017486_T_A	456	V>E		No	1000Genomes
tmp_2_9017552_G_A	478	R>H		No	1000Genomes
tmp_2_9017565_C_A	482	H>Q		No	1000Genomes
tmp_2_9017581_A_T	488	T>S		No	1000Genomes

Type	Name	Position	InterPro Accession
domain	F-box domain	1 - 50	IPR001810
repeat	Parallel beta-helix repeat	198 - 217	IPR006626-1
repeat	Parallel beta-helix repeat	238 - 260	IPR006626-2
repeat	Parallel beta-helix repeat	427 - 448	IPR006626-3
repeat	Parallel beta-helix repeat	449 - 470	IPR006626-4
repeat	Parallel beta-helix repeat	471 - 493	IPR006626-5
repeat	Parallel beta-helix repeat	494 - 516	IPR006626-6
repeat	Parallel beta-helix repeat	517 - 539	IPR006626-7
repeat	Parallel beta-helix repeat	540 - 562	IPR006626-8
repeat	Parallel beta-helix repeat	563 - 585	IPR006626-9
repeat	Parallel beta-helix repeat	586 - 608	IPR006626-10
repeat	Parallel beta-helix repeat	609 - 631	IPR006626-11
repeat	Parallel beta-helix repeat	632 - 654	IPR006626-12
repeat	Parallel beta-helix repeat	655 - 677	IPR006626-13
repeat	Parallel beta-helix repeat	719 - 741	IPR006626-14
repeat	Parallel beta-helix repeat	742 - 764	IPR006626-15
repeat	Parallel beta-helix repeat	766 - 788	IPR006626-16
repeat	Parallel beta-helix repeat	789 - 811	IPR006626-17
repeat	Parallel beta-helix repeat	834 - 856	IPR006626-18
domain	Carbohydrate-binding/sugar hydrolysis domain	341 - 515	IPR006633-1
domain	Carbohydrate-binding/sugar hydrolysis domain	540 - 676	IPR006633-2
domain	Carbohydrate-binding/sugar hydrolysis domain	685 - 810	IPR006633-3
domain	Periplasmic copper-binding protein NosD, beta helix domain	724 - 870	IPR007742
repeat	Parallel beta-helix repeat-2	534 - 573	IPR022441
domain	Right handed beta helix domain	425 - 572	IPR039448

		Description
EC Number
Subcellular Localization	Cell membrane; Single-pass membrane protein ; Cytoplasmic side Endosome membrane; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endosome membrane	The lipid bilayer surrounding an endosome.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
lipid binding	Binding to a lipid.
metal ion binding	Binding to a metal ion.

Name	Definition
endocytosis	A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
lipid transport	The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9BSJ8	ESYT1	Extended synaptotagmin-1	Homo sapiens (Human)	PR
Q3TZZ7	Esyt2	Extended synaptotagmin-2	Mus musculus (Mouse)	PR
Q3U7R1	Esyt1	Extended synaptotagmin-1	Mus musculus (Mouse)	PR
A0JJX5	SYT4	Synaptotagmin-4	Arabidopsis thaliana (Mouse-ear cress)	PR
B6ETT4	SYT2	Synaptotagmin-2	Arabidopsis thaliana (Mouse-ear cress)	PR
Q7XA06	SYT3	Synaptotagmin-3	Arabidopsis thaliana (Mouse-ear cress)	PR
Q5M7N9	esyt3	Extended synaptotagmin-3	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR