B6ETT4
PR
Gene name |
SYT2 (SYTB, At1g20080, T20H2.13) |
Protein name |
Synaptotagmin-2 |
Names |
NTMC2T1.2, Synaptotagmin B |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G20080 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for B6ETT4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-B6ETT4-F1 | Predicted | AlphaFoldDB |
51 variants for B6ETT4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_1_6962280_T_G | 15 | F>L | No | 1000Genomes | |
| tmp_1_6962302_A_T | 23 | I>F | No | 1000Genomes | |
| tmp_1_6962312_A_G | 26 | Y>C | No | 1000Genomes | |
| tmp_1_6962315_T_C | 27 | L>S | No | 1000Genomes | |
| ENSVATH01074172 | 68 | F>L | No | 1000Genomes | |
| ENSVATH01074173 | 69 | D>E | No | 1000Genomes | |
| ENSVATH04606181 | 74 | L>I | No | 1000Genomes | |
| ENSVATH11588038 | 83 | P>H | No | 1000Genomes | |
| tmp_1_6962760_T_C | 85 | M>T | No | 1000Genomes | |
| ENSVATH04606190 | 91 | K>R | No | 1000Genomes | |
| tmp_1_6962891_C_T | 95 | S>L | No | 1000Genomes | |
| tmp_1_6962911_G_T | 102 | A>S | No | 1000Genomes | |
| tmp_1_6962916_G_C | 103 | E>D | No | 1000Genomes | |
| tmp_1_6962942_C_T | 112 | S>L | No | 1000Genomes | |
| ENSVATH04606192 | 118 | L>F | No | 1000Genomes | |
| ENSVATH04606193 | 119 | T>S | No | 1000Genomes | |
| tmp_1_6962967_G_C | 120 | L>F | No | 1000Genomes | |
| tmp_1_6963097_T_C | 133 | Y>H | No | 1000Genomes | |
| ENSVATH04606204 | 149 | A>V | No | 1000Genomes | |
| tmp_1_6963155_C_A | 152 | P>H | No | 1000Genomes | |
| ENSVATH01074175 | 154 | I>V | No | 1000Genomes | |
| tmp_1_6963178_G_T | 160 | A>S | No | 1000Genomes | |
| ENSVATH04606211 | 170 | I>V | No | 1000Genomes | |
| tmp_1_6963376_T_A | 201 | D>E | No | 1000Genomes | |
| ENSVATH11588200 | 218 | A>T | No | 1000Genomes | |
| ENSVATH11588201 | 218 | A>V | No | 1000Genomes | |
| tmp_1_6963664_A_G | 236 | N>S | No | 1000Genomes | |
| ENSVATH00033099 | 259 | V>F | No | 1000Genomes | |
| ENSVATH00033099 | 259 | V>I | No | 1000Genomes | |
| tmp_1_6963826_G_C | 261 | L>F | No | 1000Genomes | |
| tmp_1_6963912_C_G | 290 | S>C | No | 1000Genomes | |
| ENSVATH13929908 | 315 | D>N | No | 1000Genomes | |
| tmp_1_6963992_GT_AT,G | 317 | V>I | No | 1000Genomes | |
| ENSVATH00033103 | 371 | K>N | No | 1000Genomes | |
| ENSVATH11588308 | 375 | S>C | No | 1000Genomes | |
| ENSVATH11588309 | 384 | V>I | No | 1000Genomes | |
| ENSVATH04606234 | 387 | E>Q | No | 1000Genomes | |
| tmp_1_6964290_C_G | 390 | P>R | No | 1000Genomes | |
| tmp_1_6964299_A_G | 393 | D>G | No | 1000Genomes | |
| ENSVATH04606235 | 397 | P>S | No | 1000Genomes | |
| ENSVATH11588310 | 398 | E>Q | No | 1000Genomes | |
| tmp_1_6964344_A_G | 408 | K>R | No | 1000Genomes | |
| ENSVATH04606236 | 417 | G>C | No | 1000Genomes | |
| tmp_1_6964436_T_G | 439 | S>A | No | 1000Genomes | |
| tmp_1_6964455_G_A | 445 | R>K | No | 1000Genomes | |
| ENSVATH11588311 | 472 | E>Q | No | 1000Genomes | |
| tmp_1_6964643_C_T | 480 | H>Y | No | 1000Genomes | |
| tmp_1_6964812_G_C | 505 | G>A | No | 1000Genomes | |
| ENSVATH04606243 | 511 | R>Q | No | 1000Genomes | |
| ENSVATH11588312 | 526 | R>C | No | 1000Genomes | |
| ENSVATH04606245 | 535 | N>T | No | 1000Genomes |
No associated diseases with B6ETT4
4 regional properties for B6ETT4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | C2 domain | 240 - 362 | IPR000008-1 |
| domain | C2 domain | 402 - 519 | IPR000008-2 |
| domain | Synaptotagmin-like mitochondrial-lipid-binding domain | 67 - 249 | IPR031468 |
| domain | Synaptotagmin, SMP domain | 67 - 247 | IPR039010 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| lipid binding | Binding to a lipid. |
| metal ion binding | Binding to a metal ion. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| lipid transport | The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. |
| protein secretion | The controlled release of proteins from a cell. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9BSJ8 | ESYT1 | Extended synaptotagmin-1 | Homo sapiens (Human) | PR |
| Q3TZZ7 | Esyt2 | Extended synaptotagmin-2 | Mus musculus (Mouse) | PR |
| Q3U7R1 | Esyt1 | Extended synaptotagmin-1 | Mus musculus (Mouse) | PR |
| A0JJX5 | SYT4 | Synaptotagmin-4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q7XA06 | SYT3 | Synaptotagmin-3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SKR2 | SYT1 | Synaptotagmin-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q5M7N9 | esyt3 | Extended synaptotagmin-3 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGIISTILGV | IGFGFGTTIG | IVIGYYLFIY | FQSTDVEDPE | IKPLVELDSE | TIATMFPEIP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| MWVKNPDFDR | IDWLNKLIGH | MWPYMDKAIC | KMAKSIAKPI | IAEQIPNYKI | DSVEFEMLTL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GSLPPSFQGM | KVYATDDKEI | IMELSVKWAG | NPNIIVVAKA | FGLKATVQVI | DLQVYATPRI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TLKPLVPSFP | CFANIFVSLM | DKPQVDFGLK | LLGADVMAIP | GLYRFVQEII | KDQVANMYLW |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PKTLNVQIMD | PSKAMKKPVG | LLSVKVIKAI | KLKKKDLLGG | SDPYVKLTLS | GDKVPGKKTV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VKHSNLNPEW | NEEFDLVVKE | PESQELQLIV | YDWEQVGKHD | KIGMNVIQLK | DLTPEEPKLM |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TLELLKSMEP | KEPVSEKSRG | QLVVEVEYKP | FKDDDIPENI | DDPNAVEKAP | EGTPSTGGLL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VVIVHEAEDL | EGKYHTNPSV | RLLFRGEERK | TKRVKKNREP | RWDEDFQFPL | DEPPINDKLH |
| 490 | 500 | 510 | 520 | 530 | |
| VEVISSSSRL | IHPKETLGYV | VINLGDVVSN | RRINDKYHLI | DSKNGRIQIE | LQWRNSS |