Q3TZZ7
PR
Gene name |
Esyt2 (D12Ertd551e, Fam62b) |
Protein name |
Extended synaptotagmin-2 |
Names |
E-Syt2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:52635 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3TZZ7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3TZZ7-F1 | Predicted | AlphaFoldDB |
38 variants for Q3TZZ7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs227291529 | 23 | E>Q | No | EVA | |
| rs3389281477 | 112 | H>L | No | EVA | |
| rs3389264312 | 159 | F>L | No | EVA | |
| rs3389268083 | 169 | Q>H | No | EVA | |
| rs1134249037 | 172 | R>* | No | EVA | |
| rs3389251036 | 177 | K>R | No | EVA | |
| rs1134608282 | 181 | E>* | No | EVA | |
| rs3403816736 | 308 | K>* | No | EVA | |
| rs3403981734 | 308 | K>M | No | EVA | |
| rs3389276332 | 324 | K>R | No | EVA | |
| rs3389239341 | 385 | E>G | No | EVA | |
| rs3389276384 | 400 | L>F | No | EVA | |
| rs3389224983 | 421 | G>* | No | EVA | |
| rs578272391 | 452 | Q>L | No | EVA | |
| rs30637871 | 454 | S>N | No | EVA | |
| rs3389224912 | 457 | L>I | No | EVA | |
| rs3389250973 | 468 | S>Y | No | EVA | |
| rs3389224936 | 472 | L>I | No | EVA | |
| rs3389233332 | 503 | T>A | No | EVA | |
| rs864275056 | 517 | H>D | No | EVA | |
| rs261677192 | 520 | R>K | No | EVA | |
| rs3389239330 | 522 | Q>H | No | EVA | |
| rs222940841 | 525 | E>D | No | EVA | |
| rs3389197448 | 546 | Q>L | No | EVA | |
| rs3389281489 | 547 | L>Q | No | EVA | |
| rs3389268244 | 549 | T>I | No | EVA | |
| rs3389251023 | 551 | D>G | No | EVA | |
| rs13466942 | 612 | S>Y | No | EVA | |
| rs3389268298 | 636 | D>V | No | EVA | |
| rs13466941 | 639 | A>P | No | EVA | |
| rs30873187 | 640 | M>V | No | EVA | |
| rs232743733 | 645 | Q>R | No | EVA | |
| rs3389276397 | 667 | S>F | No | EVA | |
| rs3389265461 | 765 | T>S | No | EVA | |
| rs3389264306 | 774 | P>L | No | EVA | |
| rs3404117721 | 775 | V>S | No | EVA | |
| rs3389250992 | 801 | S>R | No | EVA | |
| rs30869911 | 818 | V>A | No | EVA |
No associated diseases with Q3TZZ7
8 regional properties for Q3TZZ7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | C2 domain | 293 - 415 | IPR000008-1 |
| domain | C2 domain | 442 - 563 | IPR000008-2 |
| domain | C2 domain | 710 - 834 | IPR000008-3 |
| domain | Synaptotagmin-like mitochondrial-lipid-binding domain | 115 - 294 | IPR031468 |
| domain | Extended synaptotagmin, C2A domain | 309 - 429 | IPR037733 |
| domain | Extended synaptotagmin, C2B domain | 461 - 566 | IPR037749 |
| domain | Extended synaptotagmin, C-terminal C2 domain | 710 - 835 | IPR037752 |
| domain | Synaptotagmin, SMP domain | 115 - 294 | IPR039010 |
Functions
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endoplasmic reticulum-plasma membrane contact site | A contact site between the endoplasmic reticulum membrane and the plasma membrane, structured by bridging complexes. |
| extrinsic component of cytoplasmic side of plasma membrane | The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| intrinsic component of endoplasmic reticulum membrane | The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. |
| organelle membrane contact site | A zone of apposition between the membranes of an organelle with another membrane, either another membrane of the same organelle, a membrane of another organelle, or the plasma membrane. Membrane contact sites (MCSs) are structured by bridging complexes. They are specialized for communication, including the efficient traffic of small molecules such as Ca2+ ions and lipids, as well as enzyme-substrate interactions. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| calcium-dependent phospholipid binding | Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. |
| identical protein binding | Binding to an identical protein or proteins. |
| phosphatidylcholine binding | Binding to a phosphatidylcholine, a glycophospholipid in which a phosphatidyl group is esterified to the hydroxyl group of choline. |
| phosphatidylethanolamine binding | Binding to a phosphatidylethanolamine, a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. |
| phosphatidylinositol binding | Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| endocytosis | A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. |
| endoplasmic reticulum-plasma membrane tethering | The attachment of an endoplasmic reticulum membrane to the plasma membrane via molecular tethers. |
| lipid transport | The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9BSJ8 | ESYT1 | Extended synaptotagmin-1 | Homo sapiens (Human) | PR |
| Q3U7R1 | Esyt1 | Extended synaptotagmin-1 | Mus musculus (Mouse) | PR |
| B6ETT4 | SYT2 | Synaptotagmin-2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| A0JJX5 | SYT4 | Synaptotagmin-4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q7XA06 | SYT3 | Synaptotagmin-3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SKR2 | SYT1 | Synaptotagmin-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSAGGEGPE | AGPGRAGGRS | EPEAPGSALS | VDLPGLLGQL | ARSFALLLPV | YALGYLGLSF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SWVLLALGLL | AWCRRSRGLK | ASRLCRALAL | LEDEEQAVRL | GVRACDLPAW | VHFPDTERAE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| WLNKTVKHMW | PFICQFIEKL | FRETIEPAVR | GANAHLSTFS | FTKVDVGQQP | LRVNGVKVYT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ENVDKRQIIL | DLQISFVGNC | EIDLEIKRYF | CRAGVKSIQI | HGTMRVILEP | LIGDMPLVGA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LSIFFLRKPL | LEINWTGLTN | LLDIPGLNGL | SDTIILDIIS | NYLVLPNRIT | VPLVSEVQIA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QLRFPIPKGV | LRIHFIEAQD | LQGKDTYLKG | LVKGKSDPYG | IIRVGNQIFQ | SKVIKENLSP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KWNEVYEALV | YEHPGQELEI | ELFDEDPDKD | DFLGSLMIDL | IEVEKERLLD | EWFTLDEVPK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GKLHLKLEWL | TLMPDAANLD | KVLADIRADK | DQASDGLSSA | LLILYLDSAR | NLPSGKKINS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NPNPLVQMSV | GHKAQESKIR | YKTSEPVWEE | NFTFFIHNPR | RQDLEVEVKD | EQHQCSLGSL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RIPLSQLLTS | DNMTINQRFQ | LSNSGPNSTL | KMKIALRVLH | LEKQERPPDY | QHSAQVKRPS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VSKEGRKMPI | KSQMSASPGT | GGANTAPSTP | VMGVDDKPAM | EEKPQPPEAS | PLGHRDLGRS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| SSSLLASPSH | IAAKEPTPSI | ASDISLPIAT | QELRQRLRQL | ENGTTLGQSP | LGQIQLTIRH |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SSQRNKLIVV | VHSCRNLIAF | SEDGSDPYVR | MYLLPDKRRS | GRRKTHVSKK | TLNPVFDQSF |
| 790 | 800 | 810 | 820 | 830 | 840 |
| DFSVSLPEVQ | RRTLDVAVKN | SGGFLSKDKG | LLGKVLVVLA | SEELAKGWTQ | WYDLTEDGTR |
| PQVIT |