Q9SIU2
PR
Gene name |
ABH1 (CBP80, ENS, At2g13540, T10F5.8) |
Protein name |
Nuclear cap-binding protein subunit 1 |
Names |
80 kDa nuclear cap-binding protein, AtCBP80, NCBP 80 kDa subunit, Abscisic acid-hypersensitive protein 1, ABA-hypersensitive protein 1, Protein ENSALADA |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G13540 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9SIU2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9SIU2-F1 | Predicted | AlphaFoldDB |
87 variants for Q9SIU2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_2_5637132_A_C | 27 | H>P | No | 1000Genomes | |
| tmp_2_5637233_G_T | 33 | G>C | No | 1000Genomes | |
| tmp_2_5637234_G_A | 33 | G>D | No | 1000Genomes | |
| ENSVATH05437621 | 42 | S>C | No | 1000Genomes | |
| tmp_2_5637279_C_T | 48 | P>L | No | 1000Genomes | |
| tmp_2_5637381_T_C,G | 49 | F>C | No | 1000Genomes | |
| tmp_2_5637381_T_C,G | 49 | F>S | No | 1000Genomes | |
| tmp_2_5637415_G_C | 60 | K>N | No | 1000Genomes | |
| ENSVATH01764008 | 80 | Q>L | No | 1000Genomes | |
| ENSVATH05437639 | 87 | H>Q | No | 1000Genomes | |
| tmp_2_5637985_A_G | 89 | N>D | No | 1000Genomes | |
| ENSVATH13021244 | 92 | V>I | No | 1000Genomes | |
| tmp_2_5638435_C_T | 145 | P>L | No | 1000Genomes | |
| tmp_2_5638735_A_G | 184 | I>V | No | 1000Genomes | |
| ENSVATH01764014 | 195 | S>A | No | 1000Genomes | |
| ENSVATH01764014 | 195 | S>P | No | 1000Genomes | |
| tmp_2_5638769_C_A | 195 | S>Y | No | 1000Genomes | |
| ENSVATH05437654 | 202 | F>V | No | 1000Genomes | |
| ENSVATH00226367 | 205 | G>A | No | 1000Genomes | |
| ENSVATH05437663 | 217 | V>M | No | 1000Genomes | |
| ENSVATH05437664 | 229 | S>F | No | 1000Genomes | |
| tmp_2_5639300_C_G | 238 | P>R | No | 1000Genomes | |
| ENSVATH00226372 | 257 | R>L | No | 1000Genomes | |
| ENSVATH00226373 | 258 | P>S | No | 1000Genomes | |
| ENSVATH00226374 | 265 | P>S | No | 1000Genomes | |
| tmp_2_5639399_A_T | 271 | H>L | No | 1000Genomes | |
| tmp_2_5639402_C_T | 272 | S>L | No | 1000Genomes | |
| ENSVATH01764018 | 273 | R>K | No | 1000Genomes | |
| ENSVATH00226375 | 285 | T>M | No | 1000Genomes | |
| ENSVATH00226376 | 296 | I>V | No | 1000Genomes | |
| ENSVATH00226378 | 305 | V>I | No | 1000Genomes | |
| tmp_2_5640297_G_A | 345 | E>K | No | 1000Genomes | |
| ENSVATH13021282 | 352 | L>V | No | 1000Genomes | |
| ENSVATH13021298 | 363 | P>Q | No | 1000Genomes | |
| ENSVATH05437699 | 404 | M>R | No | 1000Genomes | |
| ENSVATH00226383 | 408 | T>A | No | 1000Genomes | |
| ENSVATH05437700 | 409 | R>C | No | 1000Genomes | |
| ENSVATH00226385 | 432 | F>Y | No | 1000Genomes | |
| ENSVATH14398355 | 459 | W>G | No | 1000Genomes | |
| ENSVATH13021321 | 467 | E>Q | No | 1000Genomes | |
| ENSVATH13021322 | 471 | A>T | No | 1000Genomes | |
| tmp_2_5641428_A_T | 473 | E>D | No | 1000Genomes | |
| ENSVATH05437713 | 474 | E>D | No | 1000Genomes | |
| ENSVATH13021323 | 475 | L>F | No | 1000Genomes | |
| tmp_2_5641447_G_C | 480 | A>P | No | 1000Genomes | |
| ENSVATH13021324 | 483 | N>S | No | 1000Genomes | |
| tmp_2_5641465_T_A | 486 | Y>N | No | 1000Genomes | |
| tmp_2_5641503_G_T | 498 | Q>H | No | 1000Genomes | |
| tmp_2_5641514_C_T | 502 | A>V | No | 1000Genomes | |
| tmp_2_5641523_G_A | 505 | S>N | No | 1000Genomes | |
| ENSVATH13021325 | 515 | R>L | No | 1000Genomes | |
| tmp_2_5641708_C_T | 567 | L>F | No | 1000Genomes | |
| tmp_2_5641722_C_G | 571 | N>K | No | 1000Genomes | |
| ENSVATH05437716 | 572 | D>N | No | 1000Genomes | |
| tmp_2_5641729_C_A | 574 | Q>K | No | 1000Genomes | |
| tmp_2_5641730_A_T | 574 | Q>L | No | 1000Genomes | |
| ENSVATH01764040 | 587 | N>Y | No | 1000Genomes | |
| ENSVATH00226387 | 596 | I>V | No | 1000Genomes | |
| ENSVATH14398357 | 608 | Q>H | No | 1000Genomes | |
| tmp_2_5641834_G_T | 609 | A>S | No | 1000Genomes | |
| ENSVATH00226388 | 616 | S>T | No | 1000Genomes | |
| ENSVATH14398358 | 625 | V>A | No | 1000Genomes | |
| tmp_2_5642043_G_T | 648 | R>S | No | 1000Genomes | |
| tmp_2_5642063_C_T | 655 | T>M | No | 1000Genomes | |
| tmp_2_5642081_C_G | 661 | A>G | No | 1000Genomes | |
| ENSVATH13021329 | 669 | R>Q | No | 1000Genomes | |
| ENSVATH13021330 | 670 | V>A | No | 1000Genomes | |
| tmp_2_5642125_G_A | 676 | E>K | No | 1000Genomes | |
| tmp_2_5642158_G_A | 687 | V>I | No | 1000Genomes | |
| tmp_2_5642209_A_G | 704 | K>E | No | 1000Genomes | |
| tmp_2_5642222_C_T | 708 | A>V | No | 1000Genomes | |
| tmp_2_5642251_G_A | 718 | A>T | No | 1000Genomes | |
| tmp_2_5642282_C_A | 728 | S>Y | No | 1000Genomes | |
| tmp_2_5642290_G_C | 731 | E>Q | No | 1000Genomes | |
| tmp_2_5642382_A_T | 733 | L>F | No | 1000Genomes | |
| tmp_2_5642414_T_G | 744 | V>G | No | 1000Genomes | |
| ENSVATH00226396 | 750 | P>A | No | 1000Genomes | |
| tmp_2_5642438_C_T | 752 | P>L | No | 1000Genomes | |
| ENSVATH00226398 | 758 | V>M | No | 1000Genomes | |
| ENSVATH05437722 | 765 | G>R | No | 1000Genomes | |
| tmp_2_5642514_C_G | 777 | D>E | No | 1000Genomes | |
| ENSVATH13021331 | 780 | N>I | No | 1000Genomes | |
| ENSVATH00226400 | 787 | C>S | No | 1000Genomes | |
| ENSVATH13021332 | 811 | A>V | No | 1000Genomes | |
| ENSVATH01764052 | 819 | E>Q | No | 1000Genomes | |
| ENSVATH13021347 | 827 | S>L | No | 1000Genomes | |
| ENSVATH01764055 | 831 | V>M | No | 1000Genomes |
No associated diseases with Q9SIU2
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| mRNA cap binding complex | Any protein complex that binds to an mRNA cap at any time in the lifetime of the mRNA. |
| nuclear cap binding complex | A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| RNA cap binding | Binding to a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule. |
14 GO annotations of biological process
| Name | Definition |
|---|---|
| 7-methylguanosine mRNA capping | Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript. |
| abscisic acid-activated signaling pathway involved in stomatal movement | Any abscisic acid mediated signaling pathway that is involved in stomatal movement. |
| alternative mRNA splicing, via spliceosome | The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition. |
| defense response to virus | Reactions triggered in response to the presence of a virus that act to protect the cell or organism. |
| long-day photoperiodism, flowering | A change from the vegetative to the reproductive phase as a result of detection of, or exposure to, a period of light that exceeds the critical day length. The critical day length varies between species. Although the term is long-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness falls short of the number of hours defined by 24 minus the critical day length. |
| miRNA-mediated gene silencing | A post-transcriptional gene silencing pathway in which regulatory microRNAs (miRNAs) elicit silencing of specific target genes. miRNAs are endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endonucleolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA. miRNAs are present in all the animals and in plants, whereas siRNAs are present in lower animals and in plants. |
| mRNA export from nucleus | The directed movement of mRNA from the nucleus to the cytoplasm. |
| mRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
| mRNA transcription by RNA polymerase II | The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. |
| nuclear-transcribed mRNA catabolic process | The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells. |
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. |
| primary miRNA processing | A process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule. |
| response to abscisic acid | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus. |
| RNA splicing, via endonucleolytic cleavage and ligation | Splicing of RNA via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5ZJZ6 | NCBP1 | Nuclear cap-binding protein subunit 1 | Gallus gallus (Chicken) | PR |
| Q7K4N3 | Cbp80 | Nuclear cap-binding protein subunit 1 | Drosophila melanogaster (Fruit fly) | PR |
| Q09161 | NCBP1 | Nuclear cap-binding protein subunit 1 | Homo sapiens (Human) | PR |
| Q3UYV9 | Ncbp1 | Nuclear cap-binding protein subunit 1 | Mus musculus (Mouse) | PR |
| Q56A27 | Ncbp1 | Nuclear cap-binding protein subunit 1 | Rattus norvegicus (Rat) | PR |
| Q6DIE2 | ncbp1 | Nuclear cap-binding protein subunit 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSNWKTLLLR | IGEKGPEYGT | SSDYKDHIET | CFGVIRREIE | RSGDQVLPFL | LQCAEQLPHK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IPLYGTLIGL | LNLENEDFVQ | KLVESVHANF | QVALDSGNCN | SIRILLRFMT | SLLCSKVIQP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ASLIVVFETL | LSSAATTVDE | EKGNPSWQPQ | ADFYVICILS | SLPWGGSELA | EQVPDEIERV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LVGIQAYLSI | RKNSSTSGLN | FFHNGEFESS | LAEKDFVEDL | LDRIQSLASN | GWKLESVPRP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HLSFEAQLVA | GKFHELRPIK | CMEQPSPPSD | HSRAYSGKQK | HDALTRYPQR | IRRLNIFPAN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KMEDVQPIDR | FVVEEYLLDV | LFYLNGCRKE | CASYMANLPV | TFRYEYLMAE | TLFSQILLLP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QPPFKTLYYT | LVIMDLCKAL | PGAFPAVVAG | AVRALFEKIS | DLDMESRTRL | ILWFSHHLSN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FQFIWPWEEW | AFVLDLPKWA | PKRVFVQEIL | QREVRLSYWD | KIKQSIENAT | ALEELLPPKA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GPNFMYSLEE | GKEKTEEQQL | SAELSRKVKE | KQTARDMIVW | IEETIYPVHG | FEVTLTIVVQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TLLDIGSKSF | THLVTVLERY | GQVFSKLCPD | NDKQVMLLSQ | VSTYWKNNVQ | MTAVAIDRMM |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GYRLVSNQAI | VRWVFSPENV | DQFHVSDQPW | EILGNALNKT | YNRISDLRKD | ISNITKNVLV |
| 670 | 680 | 690 | 700 | 710 | 720 |
| AEKASANARV | ELEAAESKLS | LVEGEPVLGE | NPAKMKRLKS | TVEKTGEAEL | SLRESLEAKE |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ALLNRALSET | EVLLLLLFQS | FLGVLKERLP | DPTKVRSVQD | LKSIGAEDDK | PSAMDVDSEN |
| 790 | 800 | 810 | 820 | 830 | 840 |
| GNPKKSCEVG | EREQWCLSTL | GYLTAFTRQY | ASEIWPHMEK | LESEVFSGED | VHPLFLQAIS |
| SALQFPLH |