AiPD: Autoinhibited Protein Database

Q09161

Gene name	NCBP1 (CBP80, NCBP)
Protein name	Nuclear cap-binding protein subunit 1
Names	80 kDa nuclear cap-binding protein, CBP80, NCBP 80 kDa subunit
Species	Homo sapiens (Human)
KEGG Pathway	hsa:4686
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-62 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-62 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

16 structures for Q09161

Entry ID	Method	Resolution	Chain	Position	Source
1H2T	X-ray	210 A			PDB
1H2U	X-ray	240 A			PDB
1H2V	X-ray	200 A	C	20-790	PDB
1H6K	X-ray	200 A	A/B/C	20-790	PDB
1N52	X-ray	211 A	A	1-790	PDB
1N54	X-ray	272 A	A	1-790	PDB
3FEX	X-ray	355 A	A	1-790	PDB
3FEY	X-ray	220 A	A	1-790	PDB
5OO6	X-ray	280 A	A/D/G/J/M/P/S/V	20-790	PDB
5OOB	X-ray	279 A	A/C/F/I	20-790	PDB
6D0Y	X-ray	268 A	C	24-790	PDB
7ABG	EM	780 A	A5	1-790	PDB
8BY6	EM	319 A	A	20-790	PDB
8PMP	EM	343 A	A	20-790	PDB
8PNT	EM	346 A	A	20-790	PDB
AF-Q09161-F1	Predicted				AlphaFoldDB

399 variants for Q09161

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA5147980 rs759611269	2	S>P		No	ClinGen ExAC gnomAD
rs752897059 CA5147982	4	R>W		No	ClinGen ExAC gnomAD
CA5147983 rs549300474	6	H>Y		No	ClinGen 1000Genomes ExAC gnomAD
CA374182422 rs1183515028	8	D>G		No	ClinGen TOPMed
rs1221182942 CA374182418	8	D>Y		No	ClinGen gnomAD
rs764204341 CA5148005	12	G>D		No	ClinGen ExAC gnomAD
rs902054154 CA196749129	15	P>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1188435196 CA374183833	15	P>S		No	ClinGen TOPMed
rs1170652461 CA374183918	22	S>F		No	ClinGen gnomAD
rs1254118270 CA374183912	22	S>T		No	ClinGen TOPMed
CA374183939 rs1446941455	25	N>D		No	ClinGen Ensembl
CA374183942 rs1184462536	25	N>S		No	ClinGen TOPMed
rs757529989 CA5148007	26	E>D		No	ClinGen ExAC gnomAD
CA5148006 rs754155815	26	E>V		No	ClinGen ExAC gnomAD
rs111406212 CA196749142	29	D>G		No	ClinGen Ensembl
TCGA novel	31	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5148008 rs765743935	38	V>L		No	ClinGen ExAC gnomAD
rs776693991 CA5148024	45	S>P		No	ClinGen ExAC gnomAD
CA374184227 rs1313574427	47	E>G		No	ClinGen gnomAD
TCGA novel	61	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	62	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs199768033 CA374184426	62	P>L		No	ClinGen 1000Genomes ExAC gnomAD
rs199768033 CA5148028	62	P>R		No	ClinGen 1000Genomes ExAC gnomAD
rs750751156 CA5148027	62	P>S		No	ClinGen ExAC gnomAD
rs766979856 CA5148029	63	N>K		No	ClinGen ExAC TOPMed gnomAD
rs752179444 CA5148030	64	Y>F		No	ClinGen ExAC gnomAD
CA196749463 rs923722759	65	K>R		No	ClinGen Ensembl
CA5148032 rs749990957	70	R>S		No	ClinGen ExAC TOPMed gnomAD
rs1013344069 CA196749479	74	T>A		No	ClinGen TOPMed gnomAD
CA374184583 rs1186113285	74	T>I		No	ClinGen gnomAD
rs760042997 CA5148049	76	A>G		No	ClinGen ExAC TOPMed gnomAD
rs1016432056 CA196715084	77	R>C		No	ClinGen TOPMed
rs368904475 CA5148050	77	R>H		No	ClinGen ESP ExAC gnomAD
rs1297754470 CA374164571	80	P>S		No	ClinGen TOPMed
CA5148053 rs561132889	88	T>A		No	ClinGen 1000Genomes ExAC gnomAD
rs200044823 CA5148054	90	V>A		No	ClinGen ExAC gnomAD
CA374164748 rs1232001888	92	L>R		No	ClinGen gnomAD
TCGA novel	94	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757022224 CA5148055	97	N>S		No	ClinGen ExAC gnomAD
rs757022224 CA5148056	97	N>T		No	ClinGen ExAC gnomAD
CA5148057 rs375702222	99	N>S		No	ClinGen ESP ExAC gnomAD
rs771979745 CA5148058	100	F>C		No	ClinGen ExAC TOPMed gnomAD
rs1587997993 CA374164815	103	E>K		No	ClinGen Ensembl
rs770066641 CA5148061	106	E>D		No	ClinGen ExAC gnomAD
rs78263197 CA5148060	106	E>K		No	ClinGen ExAC gnomAD
CA374164844 rs1564018751	107	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA374164859 rs1198382403	108	M>I		No	ClinGen gnomAD
CA374164851 rs1450091347	108	M>V		No	ClinGen gnomAD
rs773541128 CA5148062	110	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs763319595 CA5148063	110	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	111	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA374165006 rs1419983512	120	N>D		No	ClinGen TOPMed
CA5148065 rs201055450	121	Y>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs960465959 CA196715197	123	E>A		No	ClinGen TOPMed gnomAD
TCGA novel	124	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1158887405 CA374165072	124	A>V		No	ClinGen gnomAD
CA5148069 rs143745791	125	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1241100167 CA374165094	126	Y>C		No	ClinGen TOPMed
CA5148082 rs749413155	129	R>C		No	ClinGen ExAC TOPMed gnomAD
rs771120940 CA5148083	129	R>H		No	ClinGen ExAC TOPMed gnomAD
CA196716399 rs1006182196	131	L>F		No	ClinGen TOPMed
TCGA novel	131	L>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs113188050 CA196716400	132	S>P		No	ClinGen Ensembl
rs1447096287 CA869004899	137	C>Y		No	ClinGen TOPMed
CA196716410 rs143244138	138	H>R		No	ClinGen ESP
rs1315415591 CA374165394	138	H>Y		No	ClinGen gnomAD
TCGA novel	139	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA374165437 rs1244513780	141	A>S		No	ClinGen TOPMed gnomAD
CA196716413 rs1047126908 COSM1103039	142	A>T	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs764615349 CA5148089 COSM403880	143	P>L	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA5148088 rs761121798	143	P>S		No	ClinGen ExAC gnomAD
rs761328077 CA5148091	145	M>I		No	ClinGen ExAC gnomAD
CA5148090 rs776051965	145	M>V		No	ClinGen ExAC gnomAD
CA374165490 rs1322644123	146	V>G		No	ClinGen TOPMed
rs570584263 CA5148093	148	M>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs764931826 CA5148092	148	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1381870282 CA374165517	149	F>L		No	ClinGen gnomAD
TCGA novel	152	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5148094 rs148430361	154	S>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA196716454 rs954834241	154	S>T		No	ClinGen TOPMed
rs199742053 CA5148095	155	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	157	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1377606459 CA374165660	158	E>G		No	ClinGen gnomAD
rs367832805 CA5148097	159	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1564019572 CA374165690	159	E>G		No	ClinGen Ensembl
rs1379524559 CA374165722	160	D>V		No	ClinGen gnomAD
CA5148100 rs749362324	162	P>L		No	ClinGen ExAC gnomAD
rs781283188 CA5148099	162	P>S		No	ClinGen ExAC gnomAD
CA374165771 rs1157885895	163	Q>L		No	ClinGen gnomAD
rs766090854 CA5148116	165	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA5148117 rs751335902	166	R>Q		No	ClinGen ExAC gnomAD
rs1259880389 CA374166110	169	Y>F		No	ClinGen gnomAD
CA5148118 rs754837272	170	V>L		No	ClinGen ExAC TOPMed gnomAD
COSM199352 CA374166147 rs1247010633	171	Y>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA374166175 rs1564019760	173	F>L		No	ClinGen Ensembl
rs752719793 CA5148120	174	L>R		No	ClinGen ExAC gnomAD
rs369507099 CA5148123	189	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA196716745 rs979828315	192	M>V		No	ClinGen TOPMed
rs144152800 CA5148124	194	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs780266538 CA5148125 COSM307501	194	R>H	kidney Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	197	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA196716760 rs1047607607	198	N>S		No	ClinGen gnomAD
rs781641948 CA5148128	199	T>I		No	ClinGen ExAC gnomAD
CA5148129 rs748653256	201	S>G		No	ClinGen ExAC TOPMed gnomAD
CA5148130 rs770358840	204	K>R		No	ClinGen ExAC gnomAD
CA374168210 rs1430038305	205	R>S		No	ClinGen TOPMed
CA374168225 rs1429967001	207	Q>E		No	ClinGen gnomAD
rs1588001107 CA374168231	207	Q>R		No	ClinGen Ensembl
rs924437552 CA196717770	208	K>N		No	ClinGen Ensembl
rs755313839 CA196717778	210	H>N		No	ClinGen ExAC TOPMed gnomAD
CA196717783 rs774893629	210	H>Q		No	ClinGen Ensembl
CA5148149 rs755313839	210	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA5148150 rs781488285	211	V>G		No	ClinGen ExAC gnomAD
rs946708135 CA196717785	211	V>I		No	ClinGen TOPMed
TCGA novel	212	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs943983017 CA196717792	212	P>S		No	ClinGen Ensembl
CA5148151 rs748580819	213	M>V		No	ClinGen ExAC gnomAD
rs748737361 CA5148154	217	W>L		No	ClinGen ExAC gnomAD
CA5148155 rs146305083	219	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5148156 rs774123015	222	P>L		No	ClinGen ExAC gnomAD
rs774123015 CA196717809	222	P>R		No	ClinGen ExAC gnomAD
CA374168692 rs1200521524	232	L>V		No	ClinGen gnomAD
rs1444644035 CA374168944	243	R>H		No	ClinGen gnomAD
rs547285420 CA5148169	245	Q>R		No	ClinGen 1000Genomes ExAC gnomAD
CA374169022 rs1242946926	246	E>D		No	ClinGen TOPMed gnomAD
TCGA novel	247	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA196717979 rs752763469	247	R>W		No	ClinGen gnomAD
rs1454896839 CA374169156	253	Y>F		No	ClinGen TOPMed
TCGA novel	253	Y>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA374169213 rs1469739919	257	D>N		No	ClinGen gnomAD
rs1445045378 CA374169241	258	S>G		No	ClinGen Ensembl
rs1400817980 CA374169457	267	N>S		No	ClinGen TOPMed gnomAD
rs1403016979 CA374169510	270	P>S		No	ClinGen gnomAD
CA5148175 rs757856712	272	T>S		No	ClinGen ExAC gnomAD
CA196718046 rs992187406	275	P>S		No	ClinGen TOPMed
TCGA novel	280	S>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA374169699 rs367848815	281	V>L		No	ClinGen gnomAD
CA196718050 rs367848815	281	V>M		No	ClinGen gnomAD
CA374169733 rs1276142130	283	P>T		No	ClinGen gnomAD
CA5148176 rs377142866	284	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA374170010 rs1588001587	297	D>E		No	ClinGen Ensembl
rs1363313647 CA374170781	312	F>C		No	ClinGen gnomAD
rs746724831 CA5148198	312	F>L		No	ClinGen ExAC gnomAD
CA5148199 rs768217966	314	I>V		No	ClinGen ExAC gnomAD
rs776448255 CA5148200	315	E>D		No	ClinGen ExAC
CA196719401 rs866735277	316	E>G		No	ClinGen gnomAD
rs145175516 CA196719405	317	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA gnomAD
CA374170929 rs145175516	317	N>T		No	ClinGen ESP gnomAD
CA5148201 rs747943842	319	H>R		No	ClinGen ExAC gnomAD
CA374171008 rs1338363433	320	C>S		No	ClinGen Ensembl
rs773042637 CA5148203	322	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1587709986 CA374171096	324	S>C		No	ClinGen Ensembl
CA5148204 rs762718765	325	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs1267546890 CA374171143	326	W>C		No	ClinGen gnomAD
rs767681467 CA5148205	327	K>E		No	ClinGen ExAC gnomAD
CA196719879 rs77021424	338	S>N		No	ClinGen Ensembl
rs895821156 CA196719912	344	K>R		No	ClinGen Ensembl
CA5148224 rs760681588	345	I>S		No	ClinGen ExAC gnomAD
rs1334655231 CA374172901	351	I>V		No	ClinGen TOPMed
CA5148226 rs146487190	352	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1440314764 CA374173311	357	A>E		No	ClinGen gnomAD
rs1297799166 CA374173348	361	Q>H		No	ClinGen gnomAD
CA196721636 rs201033807	364	A>V		No	ClinGen Ensembl
rs774789588 CA5148250	365	P>T		No	ClinGen ExAC gnomAD
TCGA novel	367	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759059842 CA5148251	368	I>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	369	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	370	V>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	372	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5148253 rs752232675	374	T>A		No	ClinGen ExAC gnomAD
CA374173546 rs1564023347	376	L>F		No	ClinGen Ensembl
CA374173571 rs1266547389	377	I>T		No	ClinGen TOPMed
rs1564023359 CA374173598	379	L>Q		No	ClinGen Ensembl
CA5148256 rs753651073	381	K>R		No	ClinGen ExAC gnomAD
rs1309666909 CA374173687	384	P>R		No	ClinGen TOPMed
TCGA novel	385	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs940481465 CA196721681	386	S>C		No	ClinGen Ensembl
rs1217182356 COSM3779464 CA374174008	392	A>V	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA5148272 rs201715578	400	M>L		No	ClinGen 1000Genomes ExAC gnomAD
rs763729923 CA5148273	401	R>G		No	ClinGen ExAC gnomAD
rs191669699 CA5148274	401	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA374174204 rs1365080891	402	L>S		No	ClinGen gnomAD
rs1320278041 CA374174227	403	D>E		No	ClinGen gnomAD
CA5148275 rs757052791	403	D>N		No	ClinGen ExAC gnomAD
rs377011060 CA5148276	404	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	405	M>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1429863415 CA374174324	408	T>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA374174341 rs1384657092	409	C>Y		No	ClinGen gnomAD
CA374174551 rs1223757775	412	R>S		No	ClinGen gnomAD
CA5148298 rs562093927	414	I>V		No	ClinGen 1000Genomes ExAC gnomAD
CA196722943 rs1010959075	418	S>F		No	ClinGen Ensembl
TCGA novel	422	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	424	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA196722953 rs1043767378	427	R>C		No	ClinGen Ensembl
CA5148300 rs529407443	427	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs1463500738 CA374175070	435	D>Y		No	ClinGen TOPMed
rs751426033 CA5148322	436	C>F		No	ClinGen ExAC gnomAD
rs1463331210 CA374175263	440	D>E		No	ClinGen gnomAD
CA5148323 rs759509804	440	D>G		No	ClinGen ExAC TOPMed gnomAD
CA196723213 rs1043584863	441	P>L		No	ClinGen TOPMed
CA5148324 rs767499468	443	S>G		No	ClinGen ExAC gnomAD
rs1395347765 CA374175353	443	S>T		No	ClinGen gnomAD
CA5148326 rs77602722	446	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs77602722 CA374175435	446	P>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs753846445 CA5148325	446	P>S		No	ClinGen ExAC gnomAD
rs946680169 CA196723230	448	F>L		No	ClinGen Ensembl
CA374175531 rs1587715087	450	R>K		No	ClinGen Ensembl
rs750692037 CA5148328	452	V>I		No	ClinGen ExAC gnomAD
rs1241402370 CA374175626	454	E>Q		No	ClinGen TOPMed
CA5148329 rs758640371	456	C>F		No	ClinGen ExAC gnomAD
rs775535487 CA5148343	462	H>Y		No	ClinGen ExAC gnomAD
TCGA novel	463	Q>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs761774774 CA5148344	463	Q>L		No	ClinGen ExAC TOPMed gnomAD
rs761774774 CA374176378	463	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs929728395 CA196725491	464	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs765310353 CA5148345 COSM1103043	464	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs575725741 CA196725515	465	I>V		No	ClinGen TOPMed
rs376131263 CA196725516	468	I>T		No	ClinGen ESP TOPMed gnomAD
CA5148346 rs750531525	470	P>L		No	ClinGen ExAC gnomAD
CA374176479 rs1587718235	472	T>N		No	ClinGen Ensembl
rs1461575346 CA374176536	477	C>R		No	ClinGen gnomAD
CA374176565 rs1185118991	479	A>T		No	ClinGen gnomAD
rs1382987877 CA374176586	480	N>S		No	ClinGen gnomAD
CA5148348 rs543815167	482	T>A		No	ClinGen 1000Genomes ExAC gnomAD
rs1364986043 CA374176639	483	C>Y		No	ClinGen gnomAD
CA5148352 rs565223329	488	G>A		No	ClinGen 1000Genomes ExAC gnomAD
CA374176758 rs1380865282	489	D>E		No	ClinGen TOPMed gnomAD
rs748815530 CA5148355	492	S>N		No	ClinGen ExAC TOPMed gnomAD
CA196725571 rs893749132	493	N>H		No	ClinGen Ensembl
rs1261046976 CA374177665	493	N>K		No	ClinGen gnomAD
CA5148372 rs767878003	494	S>F		No	ClinGen ExAC gnomAD
CA196729257 rs112377432	494	S>P		No	ClinGen Ensembl
rs1457711237 CA374177698	495	L>F		No	ClinGen TOPMed
TCGA novel	499	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs756581884 CA5148374	501	A>T		No	ClinGen ExAC gnomAD
CA5148375 rs778478202	502	L>V		No	ClinGen ExAC TOPMed gnomAD
rs1587720534 CA374177905	505	A>T		No	ClinGen Ensembl
rs1420409527 CA374177943	507	A>G		No	ClinGen TOPMed
CA374177975 rs1176131002	508	F>L		No	ClinGen gnomAD
TCGA novel	508	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	510	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA374178089 rs1380325163	514	N>S		No	ClinGen TOPMed
CA5148376 rs753371425	515	D>G		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	515	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1437677053 CA374178161	519	S>G		No	ClinGen TOPMed
rs1254673124 CA374178195	520	I>M		No	ClinGen TOPMed
CA5148377 rs756898200	523	D>N		No	ClinGen ExAC gnomAD
CA374178281 rs1210269842	524	V>A		No	ClinGen TOPMed
rs1432958061 CA374178263	524	V>I		No	ClinGen gnomAD
rs1306811071 CA374178294	525	P>A		No	ClinGen gnomAD
rs138518441 CA5148379	530	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs150516377 CA5148378	530	D>N		No	ClinGen ESP ExAC
CA374178600 rs368727721	533	D>H		No	ClinGen ESP ExAC gnomAD
CA5148382 rs368727721	533	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
CA5148384 rs776589336	534	D>N		No	ClinGen ExAC TOPMed gnomAD
CA5148396 rs778501080	538	S>R		No	ClinGen ExAC gnomAD
CA374178992 rs1349230256	539	F>L		No	ClinGen gnomAD
rs749934747 CA374179043	541	P>A		No	ClinGen ExAC TOPMed gnomAD
rs758020951 CA5148398	541	P>L		No	ClinGen ExAC TOPMed gnomAD
CA5148397 rs749934747	541	P>T		No	ClinGen ExAC TOPMed gnomAD
CA196729831 rs1035915676	543	K>R		No	ClinGen Ensembl
rs1315299106 CA374179102	544	I>M		No	ClinGen gnomAD
CA5148400 rs141653335	544	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs978439391 CA196729834	544	I>V		No	ClinGen TOPMed
rs1564027630 CA374179180	549	Q>H		No	ClinGen Ensembl
CA374179207 rs1243162588	552	L>I		No	ClinGen gnomAD
CA374179236 rs1451571445	553	H>Q		No	ClinGen gnomAD
rs781092334 CA5148402	553	H>R		No	ClinGen ExAC gnomAD
rs769724189 CA374179308	557	K>I		No	ClinGen ExAC TOPMed gnomAD
CA5148404 rs769724189	557	K>T		No	ClinGen ExAC TOPMed gnomAD
rs1587721836 CA374179398	563	F>C		No	ClinGen Ensembl
CA374179471 rs1243990501	567	A>V		No	ClinGen TOPMed gnomAD
CA5148428 rs745960045	569	F>L		No	ClinGen ExAC gnomAD
rs1333061085 CA374179646	571	E>G		No	ClinGen gnomAD
rs772105621 CA5148429	572	V>I		No	ClinGen ExAC gnomAD
rs1405758678 CA374179693	574	K>R		No	ClinGen TOPMed
CA374179717 rs1587722692	575	T>I		No	ClinGen Ensembl
CA374179737 rs1349212050	577	A>S		No	ClinGen gnomAD
rs900797208 CA196730537	579	S>N		No	ClinGen Ensembl
CA5148431 rs576031865	579	S>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs769033892 CA5148432	580	D>G		No	ClinGen ExAC gnomAD
TCGA novel	584	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	586	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5148437 rs762511481	590	M>T		No	ClinGen ExAC TOPMed gnomAD
CA5148436 rs773658380	590	M>V		No	ClinGen ExAC gnomAD
TCGA novel	594	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA374180101 rs1240332038	595	R>K		No	ClinGen TOPMed
CA5148438 rs200307901 CA374180133	596	N>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA374180199 rs1463671483	599	Q>P		No	ClinGen Ensembl
CA374181442 rs1455413094	600	M>I		No	ClinGen TOPMed
rs1476216943 CA374181428	600	M>K		No	ClinGen gnomAD
CA374181453 rs1166297551	601	I>T		No	ClinGen gnomAD
rs1424724334 CA374181515	604	L>V		No	ClinGen gnomAD
rs773638183 CA5148463	608	M>T		No	ClinGen ExAC gnomAD
CA5148464 rs763301023	609	I>V		No	ClinGen ExAC gnomAD
rs766937640 CA5148465	610	R>C		No	ClinGen ExAC TOPMed gnomAD
rs189780807 CA5148466	610	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA374181670 rs1295673921	613	I>T		No	ClinGen gnomAD
rs759092106 CA5148467	614	V>I		No	ClinGen ExAC gnomAD
CA5148468 rs767122222	617	A>V		No	ClinGen ExAC gnomAD
TCGA novel	619	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs760392584 CA5148470	621	N>S		No	ClinGen ExAC gnomAD
CA5148471 rs763732944	622	W>C		No	ClinGen ExAC TOPMed gnomAD
CA5148474 rs199656608	630	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA196731882 rs76139042	630	R>H		No	ClinGen ExAC gnomAD
rs76139042 CA5148475	630	R>L		No	ClinGen ExAC gnomAD
rs1462896409 CA374181877	634	R>K		No	ClinGen TOPMed
CA5148487 rs563025088	635	L>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1426352270 CA374181995	636	F>L		No	ClinGen TOPMed
rs1459224114 CA374181990	636	F>Y		No	ClinGen gnomAD
rs760207834 CA5148488	637	V>A		No	ClinGen ExAC gnomAD
CA374182006 rs1388333402	638	W>R		No	ClinGen TOPMed gnomAD
rs530473497 CA5148490	644	T>S		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	646	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA196733972 rs980313594	646	R>G		No	ClinGen TOPMed
CA5148491 rs372649867	646	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1307706380 CA374182123	648	M>I		No	ClinGen gnomAD
CA374182135 rs1352284898	649	N>S		No	ClinGen gnomAD
CA374182159 rs1287548291	651	H>R		No	ClinGen gnomAD
CA5148495 rs781352322	655	I>F		No	ClinGen ExAC gnomAD
rs35694910 CA5148497	657	K>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA374182244 rs1473885500	659	L>V		No	ClinGen gnomAD
CA374182248 rs1180610932	660	E>K		No	ClinGen gnomAD
rs1411773079 CA374182279	662	A>T		No	ClinGen TOPMed gnomAD
CA196733993 rs1048483539	665	K>R		No	ClinGen TOPMed
rs1587726786 CA374182360	667	A>D		No	ClinGen Ensembl
rs1564029976 CA374182355	667	A>P		No	ClinGen Ensembl
rs1310351646 CA374182436	670	H>R		No	ClinGen TOPMed
rs1178608336 CA374182499	672	R>Q		No	ClinGen TOPMed gnomAD
CA374182484 rs1480959894	672	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs563951596 CA5148518	673	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA374183111 rs546371242	678	D>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5148522 rs546371242	678	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5148524 rs746257224	680	S>G		No	ClinGen ExAC gnomAD
CA374183207 rs1245387917	686	G>E		No	ClinGen gnomAD
rs372358511 CA196736167	687	V>F		No	ClinGen ESP TOPMed gnomAD
rs372358511 CA374183213	687	V>I		No	ClinGen ESP TOPMed gnomAD
rs746497048 CA196736186	689	E>D		No	ClinGen ExAC TOPMed gnomAD
rs375383269 CA196736177	689	E>K		No	ClinGen ESP
CA5148529 rs564435323	692	I>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5148528 rs779166421	692	I>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	693	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA374183294 rs1237723575	694	R>G		No	ClinGen TOPMed
rs1213983150 CA374183298	694	R>P		No	ClinGen TOPMed
rs1213983150 COSM172648 CA374183297	694	R>Q	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs369608673 CA5148531	698	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA196736229 rs373186546	698	K>T		No	ClinGen ESP TOPMed
TCGA novel	699	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1240128715 CA374183358	700	E>Q		No	ClinGen TOPMed
rs773091094 CA5148532	701	S>Y		No	ClinGen ExAC gnomAD
rs267602330 CA196736233	709	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA374183483 rs267602330	709	L>I		No	ClinGen gnomAD
rs1362619283 CA374183509	710	F>L		No	ClinGen gnomAD
rs1322221272 CA374183502	710	F>Y		No	ClinGen gnomAD
TCGA novel	712	V>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA374183524 COSM1464330 rs1315197808	712	V>I	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA374183542 rs1380665329	713	I>V		No	ClinGen gnomAD
rs1426838162 CA374183701	716	R>W		No	ClinGen gnomAD
rs765442451 CA374183762	720	I>F		No	ClinGen ExAC TOPMed gnomAD
CA5148558 rs765442451	720	I>V		No	ClinGen ExAC TOPMed gnomAD
rs749349979 CA196736872	721	L>F		No	ClinGen Ensembl
TCGA novel	726	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1310373726 CA374184380	726	V>I		No	ClinGen gnomAD
CA374184383 rs1310373726	726	V>L		No	ClinGen gnomAD
CA5148562 rs201932796	727	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA374184404 rs1275769807	727	R>P		No	ClinGen TOPMed gnomAD
CA374184402 rs1275769807	727	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA374184416 rs1347420902	728	C>R		No	ClinGen TOPMed gnomAD
TCGA novel	729	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1278052037 COSM1258794 CA374184430	729	E>K	oesophagus [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1286426586 CA374184501	734	S>G		No	ClinGen TOPMed
CA5148566 rs755750031	738	P>A		No	ClinGen ExAC gnomAD
CA374184565 rs1239779864	738	P>L		No	ClinGen TOPMed
rs148698789 CA5148567	739	W>R		No	ClinGen ESP ExAC gnomAD
TCGA novel	740	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5148568 rs748888761	741	K>N		No	ClinGen ExAC TOPMed gnomAD
rs1157431407 CA374184607	741	K>T		No	ClinGen gnomAD
CA5148569 rs770525476	742	N>S		No	ClinGen ExAC TOPMed gnomAD
rs778725072 CA5148570	744	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1273533103 CA374184667	749	Q>H		No	ClinGen TOPMed
TCGA novel	755	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA196738361 rs969569711 COSM1553885	760	Q>H	lung [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1370709913 CA374184758	760	Q>R		No	ClinGen gnomAD
rs775998628 CA374184765	761	Y>C		No	ClinGen ExAC gnomAD
rs775998628 CA5148601	761	Y>F		No	ClinGen ExAC gnomAD
TCGA novel	762	M>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5148602 rs142212526	776	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA196738388 rs958280135	777	H>Q		No	ClinGen TOPMed
rs1469769776 CA374184873	777	H>R		No	ClinGen gnomAD
rs1459058704 CA374184882	778	I>T		No	ClinGen gnomAD
CA5148603 rs377264051	781	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	782	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel CA374184948 rs1314891821	785	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen gnomAD
CA374184959 rs1338650771	786	C>R		No	ClinGen gnomAD
CA5148605 rs756788361	786	C>S		No	ClinGen ExAC gnomAD
rs764929932 CA5148606	789	Q>*		No	ClinGen ExAC gnomAD
rs764929932 CA374184992	789	Q>E		No	ClinGen ExAC gnomAD
rs749986117 CA5148607	790	A>G		No	ClinGen ExAC gnomAD
rs1279841584 CA374185006	790	A>S		No	ClinGen TOPMed

No associated diseases with Q09161

3 regional properties for Q09161

Type	Name	Position	InterPro Accession
domain	MIF4G-like, type 3	28 - 240	IPR003890
domain	MIF4G-like, type 1	326 - 470	IPR015172
domain	MIF4G-like, type 2	485 - 759	IPR015174

Functions

		Description
EC Number
Subcellular Localization	Nucleus Cytoplasm	Localized in cytoplasmic mRNP granules containing untranslated mRNAs
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

9 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
mRNA cap binding complex	Any protein complex that binds to an mRNA cap at any time in the lifetime of the mRNA.
nuclear cap binding complex	A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
ribonucleoprotein complex	A macromolecular complex that contains both RNA and protein molecules.
RNA cap binding complex	Any protein complex that binds to a specialized RNA cap structure at any time in the lifetime of the RNA.

5 GO annotations of molecular function

Name	Definition
molecular adaptor activity	The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
mRNA binding	Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
RNA 7-methylguanosine cap binding	Binding to a 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II.
RNA binding	Binding to an RNA molecule or a portion thereof.
RNA cap binding	Binding to a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule.

25 GO annotations of biological process

Name	Definition
7-methylguanosine mRNA capping	Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript.
alternative mRNA splicing, via spliceosome	The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition.
cap-dependent translational initiation	The process where the cap structure, composed of a 7- methylguanosine (m7G) group and associated cap-binding proteins, located at the 5' end of an mRNA molecule, which serves as a molecular tag that marks the spot where the 40S ribosomal subunit, is recruited and will then scan in a 5' to 3' direction until an AUG codon is encountered in an appropriate sequence context to initiate mRNA translation.
defense response to virus	Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
histone mRNA metabolic process	The chemical reactions and pathways involving an mRNA encoding a histone.
miRNA-mediated gene silencing	A post-transcriptional gene silencing pathway in which regulatory microRNAs (miRNAs) elicit silencing of specific target genes. miRNAs are endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endonucleolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA. miRNAs are present in all the animals and in plants, whereas siRNAs are present in lower animals and in plants.
mRNA 3'-end processing	Any process involved in forming the mature 3' end of an mRNA molecule.
mRNA export from nucleus	The directed movement of mRNA from the nucleus to the cytoplasm.
mRNA splicing, via spliceosome	The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
mRNA transcription by RNA polymerase II	The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter.
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
positive regulation of cell growth	Any process that activates or increases the frequency, rate, extent or direction of cell growth.
positive regulation of mRNA 3'-end processing	Any process that activates or increases the frequency, rate or extent of mRNA 3'-end processing.
positive regulation of mRNA splicing, via spliceosome	Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism.
positive regulation of phosphorylation of RNA polymerase II C-terminal domain	Any process that activates or increases the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain.
positive regulation of RNA binding	Any process that activates or increases the frequency, rate or extent of RNA binding.
positive regulation of transcription elongation by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.
pre-mRNA cleavage required for polyadenylation	The targeted, endonucleolytic cleavage of a pre-mRNA, required for polyadenylation of the 3' end. This cleavage is directed by binding sites near the 3' end of the mRNA and leaves a 3' hydoxyl end which then becomes a target for adenylation.
primary miRNA processing	A process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule.
regulation of mRNA processing	Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide.
regulation of translational initiation	Any process that modulates the frequency, rate or extent of translational initiation.
RNA catabolic process	The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
RNA splicing	The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
snRNA export from nucleus	The directed movement of snRNA from the nucleus to the cytoplasm.
spliceosomal complex assembly	The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions.

6 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5ZJZ6	NCBP1	Nuclear cap-binding protein subunit 1	Gallus gallus (Chicken)	PR
Q7K4N3	Cbp80	Nuclear cap-binding protein subunit 1	Drosophila melanogaster (Fruit fly)	PR
Q3UYV9	Ncbp1	Nuclear cap-binding protein subunit 1	Mus musculus (Mouse)	PR
Q56A27	Ncbp1	Nuclear cap-binding protein subunit 1	Rattus norvegicus (Rat)	PR
Q9SIU2	ABH1	Nuclear cap-binding protein subunit 1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q6DIE2	ncbp1	Nuclear cap-binding protein subunit 1	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR

10	20	30	40	50	60
MSRRRHSDEN	DGGQPHKRRK	TSDANETEDH	LESLICKVGE	KSACSLESNL	EGLAGVLEAD
70	80	90	100	110	120
LPNYKSKILR	LLCTVARLLP	EKLTIYTTLV	GLLNARNYNF	GGEFVEAMIR	QLKESLKANN
130	140	150	160	170	180
YNEAVYLVRF	LSDLVNCHVI	AAPSMVAMFE	NFVSVTQEED	VPQVRRDWYV	YAFLSSLPWV
190	200	210	220	230	240
GKELYEKKDA	EMDRIFANTE	SYLKRRQKTH	VPMLQVWTAD	KPHPQEEYLD	CLWAQIQKLK
250	260	270	280	290	300
KDRWQERHIL	RPYLAFDSIL	CEALQHNLPP	FTPPPHTEDS	VYPMPRVIFR	MFDYTDDPEG
310	320	330	340	350	360
PVMPGSHSVE	RFVIEENLHC	IIKSHWKERK	TCAAQLVSYP	GKNKIPLNYH	IVEVIFAELF
370	380	390	400	410	420
QLPAPPHIDV	MYTTLLIELC	KLQPGSLPQV	LAQATEMLYM	RLDTMNTTCV	DRFINWFSHH
430	440	450	460	470	480
LSNFQFRWSW	EDWSDCLSQD	PESPKPKFVR	EVLEKCMRLS	YHQRILDIVP	PTFSALCPAN
490	500	510	520	530	540
PTCIYKYGDE	SSNSLPGHSV	ALCLAVAFKS	KATNDEIFSI	LKDVPNPNQD	DDDDEGFSFN
550	560	570	580	590	600
PLKIEVFVQT	LLHLAAKSFS	HSFSALAKFH	EVFKTLAESD	EGKLHVLRVM	FEVWRNHPQM
610	620	630	640	650	660
IAVLVDKMIR	TQIVDCAAVA	NWIFSSELSR	DFTRLFVWEI	LHSTIRKMNK	HVLKIQKELE
670	680	690	700	710	720
EAKEKLARQH	KRRSDDDDRS	SDRKDGVLEE	QIERLQEKVE	SAQSEQKNLF	LVIFQRFIMI
730	740	750	760	770	780
LTEHLVRCET	DGTSVLTPWY	KNCIERLQQI	FLQHHQIIQQ	YMVTLENLLF	TAELDPHILA

VFQQFCALQA