Q5ZJZ6
Gene name |
NCBP1 (CBP80, RCJMB04_14d7) |
Protein name |
Nuclear cap-binding protein subunit 1 |
Names |
80 kDa nuclear cap-binding protein, CBP80, NCBP 80 kDa subunit |
Species |
Gallus gallus (Chicken) |
KEGG Pathway |
gga:427379 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5ZJZ6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5ZJZ6-F1 | Predicted | AlphaFoldDB |
1 variants for Q5ZJZ6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs736892610 | 343 | G>A | No | Ensembl |
No associated diseases with Q5ZJZ6
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| mRNA cap binding complex | Any protein complex that binds to an mRNA cap at any time in the lifetime of the mRNA. |
| nuclear cap binding complex | A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| RNA cap binding | Binding to a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| 7-methylguanosine mRNA capping | Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript. |
| gene silencing by RNA | A process in which an RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation. |
| mRNA export from nucleus | The directed movement of mRNA from the nucleus to the cytoplasm. |
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. |
| regulation of mRNA processing | Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide. |
| regulation of translational initiation | Any process that modulates the frequency, rate or extent of translational initiation. |
| RNA splicing | The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q7K4N3 | Cbp80 | Nuclear cap-binding protein subunit 1 | Drosophila melanogaster (Fruit fly) | PR |
| Q09161 | NCBP1 | Nuclear cap-binding protein subunit 1 | Homo sapiens (Human) | PR |
| Q3UYV9 | Ncbp1 | Nuclear cap-binding protein subunit 1 | Mus musculus (Mouse) | PR |
| Q56A27 | Ncbp1 | Nuclear cap-binding protein subunit 1 | Rattus norvegicus (Rat) | PR |
| Q9SIU2 | ABH1 | Nuclear cap-binding protein subunit 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6DIE2 | ncbp1 | Nuclear cap-binding protein subunit 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSRRRHSDDS | DDSDGQPHKR | RRTSEPSEIE | ERLESLICRV | GEKSNSSLES | NLEGLAGVLE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ADLPNYKSKI | LRILCTVARL | LPEKLTVYTT | LVGLLNARNY | NFGGEFVEAM | IRQLKECLKV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NMYNEAVHLV | RFLSDLVNCH | VIAAPSMVAM | FENFVSVTQE | EDVPQVRCDW | YIFAFLSSLP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| WVGKELYEKK | DAEMDRLLSQ | TESYLKRRQK | IHVPMLQVWT | ADKPHPQEEY | LDCLWSQIQK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LKKDRWQERH | ILRPYLAFDS | ILCEALQHNL | PPFTPPPHTE | DSVYPMPRVI | FRMFDYTDDP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EGPVMPGSHS | VERFVIEENL | HCIIKSHWKE | RKTCAAQLLS | YPGNNKIPLN | YHIVEVIFAE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LFQLPSPPHI | EVMYTTLLIE | LCKLQPGSLP | QVLAQATEML | YMRLDTMNTT | CVDRFINWFS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| HHLSNFQFRW | SWEDWSDCLT | QDLEKPKPKF | VREVLEKCMR | LSYHQRIIDI | VPASFSVLSP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ANPVCIYKYG | DESNRSLPGY | TVALCLTIAI | KNKASNDEIF | SILKDVPNPN | QDDDDDEGFT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| FNPLKIEVFV | QTLLHLAAKS | FSHSFSALAK | FHEVFKTLAE | SDEGKLHVLR | VVYEVWKNHP |
| 610 | 620 | 630 | 640 | 650 | 660 |
| QMIAVLVDKM | IRTQIVDCAA | VANWIFSSEL | AHDFTRFYIW | EILHSTIRKM | NKHVLKIHKE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LEDTKARLAR | QHKRRDSDDD | DRSSDREDGP | LEEQIERLQE | KVESAQSEQK | NLFLVIFQRF |
| 730 | 740 | 750 | 760 | 770 | 780 |
| IMLLTEHLVR | CETGGIDVFT | PWYKSCIERL | QQIFLQHHQI | IQQYMVTFEN | LLFTAELDHH |
| 790 | |||||
| ILAVFQQFCA | LQA |