Q7K4N3
PR
Gene name |
Cbp80 (CG7035) |
Protein name |
Nuclear cap-binding protein subunit 1 |
Names |
80 kDa nuclear cap-binding protein, CBP80, NCBP 80 kDa subunit |
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG7035 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q7K4N3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q7K4N3-F1 | Predicted | AlphaFoldDB |
No variants for Q7K4N3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q7K4N3 | |||||
No associated diseases with Q7K4N3
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| catalytic step 2 spliceosome | A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs. |
| mRNA cap binding complex | Any protein complex that binds to an mRNA cap at any time in the lifetime of the mRNA. |
| nuclear cap binding complex | A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| precatalytic spliceosome | A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| RNA cap binding | Binding to a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| 7-methylguanosine mRNA capping | Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript. |
| mRNA export from nucleus | The directed movement of mRNA from the nucleus to the cytoplasm. |
| mRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
| negative regulation of viral genome replication | Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication. |
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. |
| post-transcriptional gene silencing by RNA | A posttranscriptional gene silencing pathway in which regulatory RNAs elicit silencing of specific target genes, either by mRNA destabilization or inhibition of translation. |
| primary miRNA processing | A process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule. |
| siRNA processing | A process leading to the generation of a functional small interfering RNA (siRNA). Includes the cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides. May also include amplification of the siRNA by RNA-directed RNA polymerase. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5ZJZ6 | NCBP1 | Nuclear cap-binding protein subunit 1 | Gallus gallus (Chicken) | PR |
| Q09161 | NCBP1 | Nuclear cap-binding protein subunit 1 | Homo sapiens (Human) | PR |
| Q3UYV9 | Ncbp1 | Nuclear cap-binding protein subunit 1 | Mus musculus (Mouse) | PR |
| Q56A27 | Ncbp1 | Nuclear cap-binding protein subunit 1 | Rattus norvegicus (Rat) | PR |
| Q9SIU2 | ABH1 | Nuclear cap-binding protein subunit 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6DIE2 | ncbp1 | Nuclear cap-binding protein subunit 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSRRRAHDTE | DEGYDHRRNK | RRRVSENQEI | EDRLESLILR | VGERSTSSVE | SNLEGLVSVL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EADLGTFRLK | ILRILSDCAV | RMPEKCTVYT | TLVGLLNAKN | YKFGGEFVDH | MVKTFKESLK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MCRWDAARYS | LRFLADLVNC | HVISATSLLQ | LLDTMIDVSN | EDTVPQVRRD | WFVFAVLSTL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PWVGRDLYEK | KESALESLLL | RIEVYLNKRS | KKHHNALRVW | SSDAPHPQEE | YLDCLWAQIR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KLRQDNWAEK | HIPRPYLVFD | SILCEALQHN | LPTIVPPPHH | DNFEYPMPWV | VYRMFDYTDC |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PDGPNLPGAH | SIERFLIEEH | LHHIIETYHH | ERKDCAAQLL | SFPYKHKIPL | EYCIVEVVFA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ELFHMPTPRY | LDICYGSILI | ELCKLQPATL | PQVLAQATEI | LFMRIDSMNT | SCFDRFVNWF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SYHLSNFKFT | WSWDEWDSCL | LLDGEHPRPK | FIQEVLQKCL | RLSYHQRITE | MMPTTYAKLI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PLTPVPNYKY | ANEEAANLPG | TTVAHQLVVA | IRQKCTPEEV | VNILKDIPNS | GYSGEEMSDG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SFNALKIDVF | VQTLLNLGSK | SFSHSFAAIS | KFHSVFRALA | ETEEAQICIL | HNIFELWSSH |
| 610 | 620 | 630 | 640 | 650 | 660 |
| QQMMVVLIDK | LLKLQIVDCS | AVATWIFSKE | MTGEFTKLYL | WEILHLTIKK | MNKHVIKLNT |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ELSEAKEKLA | KADSSSSDSE | DDSSHKRKKP | ITHADKPSEE | VVERMEEKLE | AANVNQKRLF |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LIVFQRFIMI | LSEHLLRSDT | DGRDPDTDWY | RWTIGRLQQV | FLMHHEQVQK | YSSTLETLLF |
| 790 | |||||
| TSDLDTHILE | VFQQFVALRA |