Q9QZ47
Gene name |
Tnnt3 |
Protein name |
Troponin T, fast skeletal muscle |
Names |
TnTf, Fast skeletal muscle troponin T, fTnT |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:21957 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9QZ47
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9QZ47-F1 | Predicted | AlphaFoldDB |
1 variants for Q9QZ47
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| 131 | P>R | No |
No associated diseases with Q9QZ47
No regional properties for Q9QZ47
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9QZ47 | |||
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| troponin complex | A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin binding | Binding to monomeric or multimeric forms of actin, including actin filaments. |
| calcium-dependent protein binding | Binding to a protein or protein complex in the presence of calcium. |
| tropomyosin binding | Binding to tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle. |
| troponin C binding | Binding to troponin C, the calcium-binding subunit of the troponin complex. |
| troponin I binding | Binding to troponin I, the inhibitory subunit of the troponin complex. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| muscle contraction | A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. |
| positive regulation of calcium-dependent ATPase activity | Any process that activates or increases the frequency, rate or extent of calcium-dependent ATPase activity. |
| regulation of ATP-dependent activity | Any process that modulates the rate of an ATP-dependent activity. |
| regulation of muscle contraction | Any process that modulates the frequency, rate or extent of muscle contraction. |
| regulation of striated muscle contraction | Any process that modulates the frequency, rate or extent of striated muscle contraction. |
| sarcomere organization | The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. |
| skeletal muscle contraction | A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P13789 | TNNT2 | Troponin T, cardiac muscle | Bos taurus (Bovine) | PR |
| P02642 | TNNT2 | Troponin T, cardiac muscle isoforms | Gallus gallus (Chicken) | PR |
| P45378 | TNNT3 | Troponin T, fast skeletal muscle | Homo sapiens (Human) | PR |
| P50752 | Tnnt2 | Troponin T, cardiac muscle | Mus musculus (Mouse) | PR |
| P50753 | Tnnt2 | Troponin T, cardiac muscle | Rattus norvegicus (Rat) | PR |
| P09739 | Tnnt3 | Troponin T, fast skeletal muscle | Rattus norvegicus (Rat) | PR |
| Q27371 | mup-2 | Troponin T | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSDEETEQVE | EQYEEEEEAQ | EEEVQEEAPE | PEEVQEDAVA | EEEREEDEEE | EKPRPKLTAP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KIPEGEKVDF | DDIQKKRQNK | DLMELQALID | SHFEARKKEE | EELIALKERI | EKRRAERAEQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QRIRAEKERE | PQNRLAEEKA | RREEEDAKRR | AEDDMKKKKA | LSSMGANYSS | YLAKADQKRG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KKQTAREMKK | KILAERRKPL | NIDHLSDDKL | RDKAKELWDT | LYQLETDKFE | FGEKLKRQKY |
| 250 | 260 | 270 | |||
| DITTLRSRID | QAQKHSKKAG | ATAKGKVGGR | WK |