P50752

PR
Gene name
Tnnt2
Protein name
Troponin T, cardiac muscle
Names
TnTc, Cardiac muscle troponin T, cTnT
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:21956
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

159-250 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for P50752

Entry ID Method Resolution Chain Position Source
6KLT EM 1200 A B 212-282 PDB
6KLU EM 1200 A B 212-285 PDB
AF-P50752-F1 Predicted AlphaFoldDB

14 variants for P50752

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388501424 22 E>G No EVA
rs3388504399 47 E>D No EVA
rs229124774 55 V>A No EVA
rs3388504182 65 K>N No EVA
rs3388498436 86 N>D No EVA
rs3411667062 105 R>K No EVA
rs3390633168 108 V>S No EVA
rs236766384 109 E>D No EVA
rs3388500935 124 E>G No EVA
rs3388499378 127 K>* No EVA
rs3388503269 201 I>F No EVA
rs3388501134 210 K>R No EVA
rs3388504527 215 Q>H No EVA
rs3388498406 275 N>Y No EVA

No associated diseases with P50752

No regional properties for P50752

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P50752

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
cardiac myofibril A cardiac myofibril is a myofibril specific to cardiac muscle cells.
cardiac Troponin complex A complex of accessory proteins (cardiac troponin T, cardiac troponin I and cardiac troponin C) found associated with actin in cardiac muscle thin filaments; involved in calcium regulation important for muscle contraction.
myofibril The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.
sarcomere The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
sarcoplasm The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum.
striated muscle thin filament Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils.
troponin complex A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction.

9 GO annotations of molecular function

Name Definition
actin binding Binding to monomeric or multimeric forms of actin, including actin filaments.
identical protein binding Binding to an identical protein or proteins.
microfilament motor activity A motor activity that generates movement along a microfilament, driven by ATP hydrolysis.
protein-containing complex binding Binding to a macromolecular complex.
protein-macromolecule adaptor activity The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid.
structural constituent of cytoskeleton The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.
tropomyosin binding Binding to tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle.
troponin C binding Binding to troponin C, the calcium-binding subunit of the troponin complex.
troponin I binding Binding to troponin I, the inhibitory subunit of the troponin complex.

15 GO annotations of biological process

Name Definition
actin crosslink formation The process in which two or more actin filaments are connected together by proteins that act as crosslinks between the filaments. The crosslinked filaments may be on the same or differing axes.
atrial cardiac muscle tissue morphogenesis The process in which the anatomical structure of cardiac atrium muscle is generated and organized.
cardiac muscle contraction Muscle contraction of cardiac muscle tissue.
heart development The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
muscle contraction A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.
muscle filament sliding The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated.
negative regulation of ATP-dependent activity Any process that stops or reduces the rate of an ATP-dependent activity.
positive regulation of ATP-dependent activity Any process that activates or increases the rate of an ATP-dependent activity.
regulation of heart contraction Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body.
regulation of muscle contraction Any process that modulates the frequency, rate or extent of muscle contraction.
regulation of muscle filament sliding speed Any process that modulates the velocity of muscle filament sliding.
response to bacterium Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
response to calcium ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
sarcomere organization The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
ventricular cardiac muscle tissue morphogenesis The process in which the anatomical structures of cardiac ventricle muscle is generated and organized.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P13789 TNNT2 Troponin T, cardiac muscle Bos taurus (Bovine) PR
P02642 TNNT2 Troponin T, cardiac muscle isoforms Gallus gallus (Chicken) PR
P45378 TNNT3 Troponin T, fast skeletal muscle Homo sapiens (Human) PR
Q9QZ47 Tnnt3 Troponin T, fast skeletal muscle Mus musculus (Mouse) PR
P09739 Tnnt3 Troponin T, fast skeletal muscle Rattus norvegicus (Rat) PR
P50753 Tnnt2 Troponin T, cardiac muscle Rattus norvegicus (Rat) PR
Q27371 mup-2 Troponin T Caenorhabditis elegans PR
10 20 30 40 50 60
MSDAEEVVEE YEEEQEEEDW SEEEEDEQEE AVEEEEAGGA EPEPEGEAET EEANVEEVGP
70 80 90 100 110 120
DEEAKDAEEG PVEDTKPKPS RLFMPNLVPP KIPDGERVDF DDIHRKRVEK DLNELQTLIE
130 140 150 160 170 180
AHFENRKKEE EELISLKDRI EKRRAERAEQ QRIRNEREKE RQNRLAEERA RREEEENRRK
190 200 210 220 230 240
AEDEARKKKA LSNMMHFGGY IQKQAQTERK SGKRQTEREK KKKILAERRK ALAIDHLNED
250 260 270 280 290 300
QLREKAKELW QSIHNLEAEK FDLQEKFKQQ KYEINVLRNR INDNQKVSKT RGKAKVTGRW
K