P50753
PR
Gene name |
Tnnt2 |
Protein name |
Troponin T, cardiac muscle |
Names |
TnTc, Cardiac muscle troponin T, cTnT |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:24837 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P50753
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P50753-F1 | Predicted | AlphaFoldDB |
No variants for P50753
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P50753 | |||||
No associated diseases with P50753
No regional properties for P50753
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P50753 | |||
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| cardiac myofibril | A cardiac myofibril is a myofibril specific to cardiac muscle cells. |
| cardiac Troponin complex | A complex of accessory proteins (cardiac troponin T, cardiac troponin I and cardiac troponin C) found associated with actin in cardiac muscle thin filaments; involved in calcium regulation important for muscle contraction. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| myofibril | The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism. |
| sarcomere | The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. |
| sarcoplasm | The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum. |
| striated muscle thin filament | Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils. |
| troponin complex | A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin binding | Binding to monomeric or multimeric forms of actin, including actin filaments. |
| protein-containing complex binding | Binding to a macromolecular complex. |
| protein-macromolecule adaptor activity | The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid. |
| structural constituent of cytoskeleton | The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. |
| tropomyosin binding | Binding to tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle. |
| troponin C binding | Binding to troponin C, the calcium-binding subunit of the troponin complex. |
| troponin I binding | Binding to troponin I, the inhibitory subunit of the troponin complex. |
15 GO annotations of biological process
| Name | Definition |
|---|---|
| actin crosslink formation | The process in which two or more actin filaments are connected together by proteins that act as crosslinks between the filaments. The crosslinked filaments may be on the same or differing axes. |
| atrial cardiac muscle tissue morphogenesis | The process in which the anatomical structure of cardiac atrium muscle is generated and organized. |
| cardiac muscle contraction | Muscle contraction of cardiac muscle tissue. |
| heart development | The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. |
| muscle contraction | A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. |
| muscle filament sliding | The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated. |
| negative regulation of ATP-dependent activity | Any process that stops or reduces the rate of an ATP-dependent activity. |
| positive regulation of ATP-dependent activity | Any process that activates or increases the rate of an ATP-dependent activity. |
| regulation of heart contraction | Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body. |
| regulation of muscle contraction | Any process that modulates the frequency, rate or extent of muscle contraction. |
| regulation of muscle filament sliding speed | Any process that modulates the velocity of muscle filament sliding. |
| response to bacterium | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. |
| response to calcium ion | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. |
| sarcomere organization | The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. |
| ventricular cardiac muscle tissue morphogenesis | The process in which the anatomical structures of cardiac ventricle muscle is generated and organized. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P13789 | TNNT2 | Troponin T, cardiac muscle | Bos taurus (Bovine) | PR |
| P02642 | TNNT2 | Troponin T, cardiac muscle isoforms | Gallus gallus (Chicken) | PR |
| P45378 | TNNT3 | Troponin T, fast skeletal muscle | Homo sapiens (Human) | PR |
| Q9QZ47 | Tnnt3 | Troponin T, fast skeletal muscle | Mus musculus (Mouse) | PR |
| P50752 | Tnnt2 | Troponin T, cardiac muscle | Mus musculus (Mouse) | PR |
| P09739 | Tnnt3 | Troponin T, fast skeletal muscle | Rattus norvegicus (Rat) | PR |
| Q27371 | mup-2 | Troponin T | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSDAEEEVVE | YEEEQEEEDW | SEEEEDEQEE | AVEEEDGEAE | PDPEGEAEAE | EDKAEEVGPD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EEARDAEDGP | VEDSKPKPSR | LFMPNLVPPK | IPDGERVDFD | DIHRKRMEKD | LNELQTLIEA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HFENRKKEEE | ELISLKDRIE | KRRAERAEQQ | RIRNEREKER | QNRLAEERAR | REEEENRRKA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EDEARKKKAL | SNMMHFGGYI | QKAQTERKSG | KRQTEREKKK | KILAERRKVL | AIDHLNEDQL |
| 250 | 260 | 270 | 280 | 290 | |
| REKAKELWQS | IHNLEAEKFD | LQEKFKQQKY | EINVLRNRIN | DNQKVSKTRG | KAKVTGRWK |