Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P13789
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P13789-F1 | Predicted | AlphaFoldDB |
No variants for P13789
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P13789 | |||||
No associated diseases with P13789
No regional properties for P13789
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P13789 | |||
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| troponin complex | A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| tropomyosin binding | Binding to tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle. |
| troponin C binding | Binding to troponin C, the calcium-binding subunit of the troponin complex. |
| troponin I binding | Binding to troponin I, the inhibitory subunit of the troponin complex. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| cardiac muscle contraction | Muscle contraction of cardiac muscle tissue. |
| muscle contraction | A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. |
| regulation of muscle contraction | Any process that modulates the frequency, rate or extent of muscle contraction. |
| sarcomere organization | The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P02642 | TNNT2 | Troponin T, cardiac muscle isoforms | Gallus gallus (Chicken) | PR |
| P45378 | TNNT3 | Troponin T, fast skeletal muscle | Homo sapiens (Human) | PR |
| Q9QZ47 | Tnnt3 | Troponin T, fast skeletal muscle | Mus musculus (Mouse) | PR |
| P50752 | Tnnt2 | Troponin T, cardiac muscle | Mus musculus (Mouse) | PR |
| P09739 | Tnnt3 | Troponin T, fast skeletal muscle | Rattus norvegicus (Rat) | PR |
| P50753 | Tnnt2 | Troponin T, cardiac muscle | Rattus norvegicus (Rat) | PR |
| Q27371 | mup-2 | Troponin T | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSDVEEAVEE | YEEQEEAAEE | EHEEAVEEEA | GGEAEAGEPC | TAEDGEEEEG | REAEDGPVEE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FKPKPRPFMP | NLVPPKIPDG | ERVDFDDIHR | KRMEKDLNEL | QTLIEAHFEN | RKKEEEELVS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LKDRIEKRRA | ERAEQQRIRA | EREKERQTRL | AEERARREEE | ESRRKAEDEA | RKKKALSNMM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HFGGYIQKAQ | TERKSGKRQT | EREKKKKILA | ERRKVLAIDH | LNEDQLREKA | KELWQMIYDL |
| 250 | 260 | 270 | 280 | ||
| EAEKFDLQEK | FKQQKYEINV | LRNRINDNQK | VSKTRGKAKV | TGRWK |