Q9QXG4

PR
Gene name
Acss2 (Acas2, Acecs1)
Protein name
Acetyl-coenzyme A synthetase, cytoplasmic
Names
Acetate--CoA ligase, Acetyl-CoA synthetase, ACS, AceCS, Acetyl-CoA synthetase 1, AceCS1, Acyl-CoA synthetase short-chain family member 2, Acyl-activating enzyme, Propionate--CoA ligase
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:60525
EC number
6.2.1.1: Acid--thiol ligases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-75 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9QXG4

Entry ID Method Resolution Chain Position Source
AF-Q9QXG4-F1 Predicted AlphaFoldDB

32 variants for Q9QXG4

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388602979 46 R>H No EVA
rs3388599647 85 D>V No EVA
rs3388601589 139 R>S No EVA
rs3392465332 154 K>N No EVA
rs3388605304 163 V>M No EVA
rs3388597004 177 M>I No EVA
rs3388603787 183 L>F No EVA
rs3388603819 200 C>Y No EVA
rs3388604026 236 K>N No EVA
rs3388598588 242 F>S No EVA
rs3388604022 250 V>G No EVA
rs3388602938 270 V>A No EVA
rs3388603010 288 W>* No EVA
rs3388603782 312 F>I No EVA
rs3388596956 336 Y>C No EVA
rs3388596147 341 F>S No EVA
rs3388606616 411 T>S No EVA
rs3388600669 419 F>L No EVA
rs3388605314 421 D>N No EVA
rs3388606625 446 A>V No EVA
rs3388603872 447 W>* No EVA
rs3388606067 486 P>T No EVA
rs3388595564 500 I>V No EVA
rs3388602936 527 R>H No EVA
rs3388600679 530 Y>F No EVA
rs3388606636 542 K>T No EVA
rs3388601612 556 R>W No EVA
rs3388606579 622 T>S No EVA
rs3388605252 665 R>P No EVA
rs3388606652 680 T>A No EVA
rs3388606001 686 P>S No EVA
rs579821110 700 T>A No EVA

No associated diseases with Q9QXG4

1 regional properties for Q9QXG4

Type Name Position InterPro Accession
domain Septin-type guanine nucleotide-binding (G) domain 295 - 571 IPR030379

Functions

Description
EC Number 6.2.1.1 Acid--thiol ligases
Subcellular Localization
  • Cytoplasm, cytosol
  • Cytoplasm
  • Nucleus
  • Glucose deprivation results in its AMPK-dependent phosphorylation and subsequent nuclear translocation
  • Phosphorylation at Ser-659, leads to exposure of its nuclear localization signal which is required for its interaction with KPNA1 and subsequent translocation to the nucleus (By similarity)
  • Found in the cytoplasm in undifferentiated neurons and upon differentiation, translocates to nucleus (PubMed:28562591)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
acetate-CoA ligase activity Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
propionate-CoA ligase activity Catalysis of the reaction: ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA.

4 GO annotations of biological process

Name Definition
acetate biosynthetic process The chemical reactions and pathways resulting in the formation of acetate, the anion of acetic acid.
acetyl-CoA biosynthetic process The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated.
lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
propionate biosynthetic process The chemical reactions and pathways resulting in the formation of propionate, the anion derived from propionic acid.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q68CK6 ACSM2B Acyl-coenzyme A synthetase ACSM2B, mitochondrial Homo sapiens (Human) PR
Q08AH3 ACSM2A Acyl-coenzyme A synthetase ACSM2A, mitochondrial Homo sapiens (Human) PR
Q9NR19 ACSS2 Acetyl-coenzyme A synthetase, cytoplasmic Homo sapiens (Human) PR
Q9D2R0 Aacs Acetoacetyl-CoA synthetase Mus musculus (Mouse) PR
Q8K0L3 Acsm2 Acyl-coenzyme A synthetase ACSM2, mitochondrial Mus musculus (Mouse) PR
Q9JMI1 Aacs Acetoacetyl-CoA synthetase Rattus norvegicus (Rat) PR
O70490 Acsm2 Acyl-coenzyme A synthetase ACSM2, mitochondrial Rattus norvegicus (Rat) PR
Q84P17 AAE18 Probable acyl-activating enzyme 18, peroxisomal Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MGLPEERRKS GSGSRAREET GAEGRVRGWS PPPEVRRSAH VPSLQRYREL HRRSVEEPRE
70 80 90 100 110 120
FWGNIAKEFY WKTACPGPFL QYNFDVTKGK IFTEWMKGAT TNICYNVLDR NVHEKKLGDK
130 140 150 160 170 180
VAFYWEGNEP GETTKITYRE LLVQVCQFSN VLRKQGIQKG DRVAIYMPMI LELVVAMLAC
190 200 210 220 230 240
ARLGALHSIV FAGFSAESLC ERILDSSCCL LITTDAFYRG EKLVNLKELA DESLEKCREK
250 260 270 280 290 300
GFPVRCCIVV KHLGRAELGM NDSPSQSPPV KRPCPDVQIC WNEGVDLWWH ELMQQAGDEC
310 320 330 340 350 360
EPEWCDAEDP LFILYTSGST GKPKGVVHTI GGYMLYVATT FKYVFDFHPE DVFWCTADIG
370 380 390 400 410 420
WITGHSYVTY GPLANGATSV LFEGIPTYPD EGRLWSIVDK YKVTKFYTAP TAIRMLMKFG
430 440 450 460 470 480
DDPVTKHSRA SLQVLGTVGE PINPEAWLWY HRVVGSQRCP IVDTFWQTET GGHMLTPLPG
490 500 510 520 530 540
ATPMKPGSAS FPFFGVAPAI LNESGEELEG EAEGYLVFKQ PWPGIMRTVY GNHTRFETTY
550 560 570 580 590 600
FKKFPGYYVT GDGCRRDQDG YYWITGRIDD MLNVSGHLLS TAEVESALVE HEAVAEAAVV
610 620 630 640 650 660
GHPHPVKGEC LYCFVTLCDG HTFSPTLTEE LKKQIREKIG PIATPDYIQN APGLPKTRSG
670 680 690 700
KIMRRVLRKI AQNDHDLGDT STVADPSVIN HLFSHRCLTT Q